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Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Arresting developments in heptahelical receptor signaling and regulation.
TL;DR: There has been a marked shift in the focus of research into arrestin function because it has become clear that they not only prevent signaling from 7T MRs but also initiate and direct new signals from the very 7TMRs that they desensitize.
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Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor
TL;DR: The location of multiple GRK2 and GRK5 phosphoacceptor sites at the extreme carboxyl terminus of the β2AR is highly reminiscent of GRK1-mediated phosphorylation of rhodopsin.
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β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
TL;DR: A role of β-arrestins in the regulation of NF-κB-mediated gene regulation is uncovered by using a yeast two-hybrid screen and finding it independent of the type of stimulus used for NF-kkB activation.
Journal Article
Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.
TL;DR: It is shown that, of several beta-adrenergic receptor-blocking drugs tested, only two, ICI 118551 and betaxolol, inhibit the basal signaling activity of the beta 2-adRenergic receptor, thus acting as negative antagonists.
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Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins
TL;DR: This review focuses on several specific examples of G protein-coupled receptor-associated scaffolds and the roles they may play in organizing receptor-initiated signaling pathways in the cardiovascular system and other tissues.