Robert J. Lefkowitz

TL;DR: The quantitative extent of receptor phosphorylation and functional impairment are virtually identical to those previously observed when intact turkey erythrocytes were incubated with cyclic AMP.

TL;DR: The data indicate that the regions of the alpha 1AR that determine coupling to phosphatidylinositol metabolism are similar to those previously shown to be involved in coupling of beta 2AR to adenylate cyclase stimulation and that point mutations of a G-protein-coupled receptor can cause remarkable increases in sensitivity of biological response.

TL;DR: beta-arrestins are increasingly found to perform analogous functions for receptors from structurally diverse classes, including atypical 7TMRs such as frizzled and smoothened, the nicotinic cholinergic receptors, receptor tyrosine kinases, and cytokine receptors, thereby regulating a growing list of cellular processes such as chemotaxis, apoptosis, and metastasis.

TL;DR: The cloned human alpha 2AR is cloned by using the polymerase chain reaction with oligonucleotide primers homologous to conserved regions of the previously clonedAlpha 2ARs, the genes for which are located on human chromosomes 4 (C4) and 10 (C10) and the deduced amino acid sequence encodes a protein of 450 amino acids whose putative topology is similar to that of the family of guanine nucleotide-binding protein-c

TL;DR: The results indicate that rhodopsin kinase and β ARK both rely on the function of isoprenyl moieties for their translocation and activity, illustrating distinct, though related, modes of biological regulation of receptor function.