R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Journal ArticleDOI
Effector coupling mechanisms of the cloned 5-HT1A receptor.
Annick Fargin,John R. Raymond,John W. Regan,Susanna Cotecchia,Robert J. Lefkowitz,Marc G. Caron +5 more
TL;DR: Findings indicate that like the M2 and M3 muscarinic cholinergic receptors, the 5-HT1A receptor can couple to multiple transduction pathways with varying efficiencies via pertussis toxin-sensitive G-proteins.
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Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase *
TL;DR: The specific and Ca-dependent Rv/RK interaction is necessary for the inhibitory effect of Rv on rhodopsin phosphorylation and may play an important role in photoreceptor light adaptation.
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Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.
Susanna Cotecchia,Brian K. Kobilka,Kiefer W. Daniel,R D Nolan,E Y Lapetina,Marc G. Caron,Robert J. Lefkowitz,John W. Regan +7 more
TL;DR: Results show that each of the alpha-adrenergic receptor subtypes can couple to multiple signal transduction pathways and suggest several generalities about the effector coupling mechanisms of G-protein-coupled receptors.
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A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits
Jianqiang Chen,Michael DeVivo,Jane Dingus,Anya Harry,Jingrong Li,Jin-Liang Sui,Donna J. Carty,Jonathan L. Blank,John H. Exton,Robert H. Stoffel,James Inglese,Robert J. Lefkowitz,Diomedes E. Logothetis,John D. Hildebrandt,Ravi lyengar +14 more
TL;DR: The region defined by residues 956 to 982 of adenylyl cyclase 2 may contain determinants important for receiving signals from G beta gamma, which is conserved in regions of potassium channels and beta-adrenergic receptor kinases that participate in G beta Gamma interactions.
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Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
TL;DR: Although βarr2 appears to be the most prominent and proximal determinant of μOR desensitization and morphine tolerance, in the absence of this mechanism, the contributions of a PKC-dependent regulatory system become readily apparent.