R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Journal ArticleDOI
Molecular pharmacology of beta-adrenergic receptors—A status report
Journal ArticleDOI
Surface interaction of [3H]norepinephrine with cultured chick embryo myocardial cells
Robert J. Lefkowitz,Robert J. Lefkowitz,Donald O'Hara,Donald O'Hara,Joseph B. Warshaw,Joseph B. Warshaw +5 more
TL;DR: Cultured chick embryo cardiac myoblasts specifically bind [ 3 H]nonrepinephrine, rapid and reversible, and the sites appear to be present predominantly at the cell surface in that nonREPinephrine linked to agarose beads competes for th sites.
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Insulin Activity: The Solid Matrix
R W Butcher,Oscar B. Crofford,S Gammeltoff,J Gliemann,J R Gavin rd,I D Goldfine,C. R. Kahn,M Rodbell,Jesse Roth,L Jarrett,Joseph Larner,Robert J. Lefkowitz,R Levine,G. V. Marinetti +13 more
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The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility
Jihee Kim,Chad A. Grotegut,James W. Wisler,Lan Mao,Paul B. Rosenberg,Howard A. Rockman,Robert J. Lefkowitz,Robert J. Lefkowitz +7 more
TL;DR: Chronic treatment with carvedilol, but not other β-blockers, indeed enhances contractile force in skeletal muscle and this is mediated by β-arrestin 1, and this distinctive signaling profile could present an innovative approach to treating sarcopenia, frailty, and secondary muscle wasting.
Journal ArticleDOI
Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism.
J A Heinsimer,Albert O. Davies,R W Downs,Michael A. Levine,Allen M. Spiegel,M K Drezner,A De Lean,Keith A. Wreggett,M G Caron,Robert J. Lefkowitz +9 more
TL;DR: In vitro findings in erythrocytes taken together with the recent observations that in vivo isoproterenol-stimulated adenylate cyclase activity is decreased in patients with PHP are consistent with the notion that N is a bifunctional protein interacting with both R and the adanine nucleotide regulatory protein.