R
Robert N. O'Meally
Researcher at Johns Hopkins University School of Medicine
Publications - 43
Citations - 3175
Robert N. O'Meally is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Phosphorylation & Proteome. The author has an hindex of 22, co-authored 38 publications receiving 2587 citations. Previous affiliations of Robert N. O'Meally include Johns Hopkins University.
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Journal ArticleDOI
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
Weibo Luo,Hongxia Hu,Ryan Chang,Jun Zhong,Matthew K. Knabel,Robert N. O'Meally,Robert N. Cole,Akhilesh Pandey,Gregg L. Semenza +8 more
TL;DR: In this article, the pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM 2 gene, and they are activated by hypoxia-inducible factor 1 (HIF-1).
Journal ArticleDOI
Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
Zachary T. Monahan,Veronica H Ryan,Abigail M. Janke,Kathleen A. Burke,Shannon N Rhoads,Gül H. Zerze,Robert N. O'Meally,Gregory L. Dignon,Alexander E. Conicella,Wenwei Zheng,Robert B. Best,Robert N. Cole,Jeetain Mittal,Frank Shewmaker,Nicolas L. Fawzi +14 more
TL;DR: It is shown that phosphomimetic FUS reduces aggregation in human and yeast cell models, and can ameliorate FUS‐associated cytotoxicity, suggesting a potential treatment pathway amenable to pharmacologic modulation.
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Proteomic Analysis of Chinese Hamster Ovary Cells
Deniz Baycin-Hizal,David L. Tabb,Raghothama Chaerkady,Lily Chen,Nathan E. Lewis,Harish Nagarajan,Vishaldeep Sarkaria,Amit Kumar,Daniel Wolozny,Joe Colao,Elena F. Jacobson,Yuan Tian,Robert N. O'Meally,Sharon S. Krag,Robert N. Cole,Bernhard O. Palsson,Hui Zhang,Michael J. Betenbaugh +17 more
TL;DR: This first large-scale proteomic analysis of Chinese hamster ovary (CHO) cells will enhance the knowledge base about CHO capabilities for recombinant expression and provide information useful in cell engineering efforts aimed at modifying CHO cellular functions.
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A comprehensive map of the human urinary proteome.
Arivusudar Marimuthu,Robert N. O'Meally,Raghothama Chaerkady,Yashwanth Subbannayya,Vishalakshi Nanjappa,Praveen Kumar,Dhanashree S. Kelkar,Sneha M. Pinto,Rakesh Sharma,Santosh Renuse,Renu Goel,Rita Christopher,Bernard Delanghe,Robert N. Cole,H. C. Harsha,Akhilesh Pandey +15 more
TL;DR: A comprehensive analysis of human urinary proteome from healthy individuals using high-resolution Fourier transform mass spectrometry identified 1,823 proteins, of which 671 proteins have not previously been reported as constituents of human urine.
Journal ArticleDOI
Identification and Quantification of S-Nitrosylation by Cysteine Reactive Tandem Mass Tag Switch Assay
Christopher I. Murray,Helge Uhrigshardt,Robert N. O'Meally,Robert N. Cole,Jennifer E. Van Eyk +4 more
TL;DR: Results indicate a possible mechanism for the cell to gauge the magnitude of oxidative stimuli through the progressive and specific accumulation of modified redox-switches through the specific detection of SNO-modifications and determination of individual protein thiol-reactivity.