S
Sam Tischfield
Researcher at Broad Institute
Publications - 3
Citations - 554
Sam Tischfield is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Minor allele frequency. The author has an hindex of 3, co-authored 3 publications receiving 542 citations. Previous affiliations of Sam Tischfield include Massachusetts Institute of Technology & Boston Children's Hospital.
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Journal ArticleDOI
Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies
Brendan J. Keating,Sam Tischfield,Sam Tischfield,Sarah S. Murray,Tushar Bhangale,Thomas S. Price,Joseph T. Glessner,Luana Galver,Jeffrey C. Barrett,Struan F.A. Grant,Deborah N. Farlow,Hareesh R. Chandrupatla,Mark Hansen,Saad Ajmal,George J. Papanicolaou,Yiran Guo,Mingyao Li,Stephanie DerOhannessian,Paul I.W. de Bakker,Paul I.W. de Bakker,Swneke D. Bailey,Alexandre Montpetit,Andrew C. Edmondson,Kent D. Taylor,Xiaowu Gai,Susanna S. Wang,Myriam Fornage,Tamim H. Shaikh,Leif Groop,Michael Boehnke,Alistair S. Hall,Andrew T. Hattersley,Edward C. Frackelton,Nick Patterson,Charleston W. K. Chiang,Charleston W. K. Chiang,Cecelia E. Kim,Richard R. Fabsitz,Willem H. Ouwehand,Alkes L. Price,Patricia B. Munroe,Mark J. Caulfield,Thomas A. Drake,Eric Boerwinkle,David Reich,David Reich,A. Stephen Whitehead,Thomas P. Cappola,Nilesh J. Samani,A. Jake Lusis,Eric E. Schadt,James G. Wilson,Wolfgang Koenig,Mark I. McCarthy,Sekar Kathiresan,Sekar Kathiresan,Stacey Gabriel,Hakon Hakonarson,Sonia S. Anand,Muredach P. Reilly,James C. Engert,Deborah A. Nickerson,Daniel J. Rader,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Garret A. FitzGerald +66 more
TL;DR: A gene-centric 50 K single nucleotide polymorphism (SNP) array to assess potentially relevant loci across a range of cardiovascular, metabolic and inflammatory syndromes and it is demonstrated that the IBC array can be used to complement GWAS, increasing coverage in high priority CVD-related lociAcross all major HapMap populations.
Journal ArticleDOI
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height
Matthew B. Lanktree,Yiran Guo,Yiran Guo,Muhammed Murtaza,Joseph T. Glessner,Swneke D. Bailey,N. Charlotte Onland-Moret,Guillaume Lettre,Halit Ongen,Ramakrishnan Rajagopalan,Toby Johnson,Haiqing Shen,Christopher P. Nelson,Christopher P. Nelson,N. Klopp,Jens Baumert,Sandosh Padmanabhan,Nathan Pankratz,Nathan Pankratz,James S. Pankow,Sonia Shah,Kira C. Taylor,John Barnard,Bas J M Peters,Cliona M. Maloney,Maximilian T. Lobmeyer,Alice Stanton,M. Hadi Zafarmand,Simon P. R. Romaine,Amar J. Mehta,Erik P A Van Iperen,Yan Gong,Thomas S. Price,Erin N. Smith,Cecilia E. Kim,Yun Li,Folkert W. Asselbergs,Larry D. Atwood,Kristian M. Bailey,Deepak L. Bhatt,Florianne Bauer,Elijah R. Behr,Tushar Bhangale,Jolanda M. A. Boer,Bernhard O. Boehm,Jonathan P. Bradfield,Morris Brown,Peter S. Braund,Peter S. Braund,Paul Burton,Cara L. Carty,Hareesh R. Chandrupatla,Wei Chen,John M. C. Connell,Chrysoula Dalgeorgou,Anthonius de Boer,Fotios Drenos,Clara C. Elbers,James C. Fang,Caroline S. Fox,Edward C. Frackelton,Barry D. Fuchs,Clement E. Furlong,Quince Gibson,Christian Gieger,Anuj Goel,Diederik E. Grobbee,Claire E. Hastie,Philip Howard,Guan-Hua Huang,W. Craig Johnson,Qing Li,Marcus E. Kleber,Barbara E.K. Klein,Ronald Klein,Charles Kooperberg,Bonnie Ky,Andrea Z. LaCroix,Paul N. Lanken,Mark Lathrop,Mingyao Li,Vanessa Marshall,Olle Melander,Frank D. Mentch,Nuala J. Meyer,Keri L. Monda,Alexandre Montpetit,Gurunathan Murugesan,Karen Nakayama,Dave Nondahl,Abiodun Onipinla,Suzanne Rafelt,Suzanne Rafelt,Stephen Newhouse,F. George Otieno,Sanjey R. Patel,Mary E. Putt,Santiago Rodriguez,Radwan Safa,Douglas B. Sawyer,Pamela J. Schreiner,Claire L. Simpson,Suthesh Sivapalaratnam,Sathanur R. Srinivasan,Christine Suver,Gary Swergold,Nancy K. Sweitzer,Kelly A. Thomas,Barbara Thorand,Nicholas J. Timpson,Sam Tischfield,Martin D. Tobin,Mac Iej Tomaszweski,Mac Iej Tomaszweski,W. M. Monique Verschuren,Chris Wallace,Bernhard R. Winkelmann,Haitao Zhang,Dongling Zheng,Li Zhang,Joseph M. Zmuda,Robert Clarke,Anthony J. Balmforth,John Danesh,Ian N. M. Day,Nicholas J. Schork,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Christian Delles,David Duggan,Aroon D. Hingorani,Joel N. Hirschhorn,Joel N. Hirschhorn,Marten H. Hofker,Steve E. Humphries,Mika Kivimäki,Debbie A Lawlor,Kandice Kottke-Marchant,Jessica L. Mega,Braxton D. Mitchell,David A. Morrow,Jutta Palmen,Susan Redline,Denis C. Shields,Alan R. Shuldiner,Patrick M. A. Sleiman,George Davey Smith,Martin Farrall,Yalda Jamshidi,David C. Christiani,Juan P. Casas,Alistair S. Hall,Pieter A. Doevendans,Jason D. Christie,Gerald S. Berenson,Sarah S. Murray,Thomas Illig,Gerald W. Dorn,Thomas P. Cappola,Eric Boerwinkle,Peter S. Sever,Daniel J. Rader,Muredach P. Reilly,Mark J. Caulfield,Philippa J. Talmud,Eric J. Topol,James C. Engert,Kai Wang,Anna F. Dominiczak,Anders Hamsten,Sean P. Curtis,Roy L. Silverstein,Leslie A. Lange,Marc S. Sabatine,Mieke D. Trip,Danish Saleheen,John F. Peden,Karen J. Cruickshanks,Winfried März,Jeffrey R. O'Connell,Olaf H. Klungel,Cisca Wijmenga,Anke-Hilse Maitland-van der Zee,Eric E. Schadt,Julie A. Johnson,Gail P. Jarvik,George J. Papanicolaou,Struan F.A. Grant,Patricia B. Munroe,Kari E. North,Nilesh J. Samani,Nilesh J. Samani,Wolfgang Koenig,Tom R. Gaunt,Sonia S. Anand,Yvonne T. van der Schouw,Nicole Soranzo,Garret A. FitzGerald,Alexander P. Reiner,Robert A. Hegele,Hakon Hakonarson,Brendan J. Keating +202 more
TL;DR: It is shown that dense coverage of genes for uncommon SNPs, coupled with large-scale meta-analysis, can successfully identify additional variants associated with a common complex trait.
Journal ArticleDOI
Use of weighted reference panels based on empirical estimates of ancestry for capturing untyped variation.
Matthew Egyud,Matthew Egyud,Zofia K. Z. Gajdos,Zofia K. Z. Gajdos,Zofia K. Z. Gajdos,Johannah L. Butler,Johannah L. Butler,Sam Tischfield,Sam Tischfield,Loic Le Marchand,Laurence N. Kolonel,Christopher A. Haiman,Brian E. Henderson,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn +15 more
TL;DR: Weighted reference panels are potentially useful for both the selection of tag SNPs in diverse populations and perhaps in the design of reference panels for imputation of untyped genotypes in genome-wide association studies in admixed populations.