S
Sang Yong Kim
Researcher at New York University
Publications - 20
Citations - 843
Sang Yong Kim is an academic researcher from New York University. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 11, co-authored 20 publications receiving 600 citations.
Papers
More filters
Journal ArticleDOI
Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells
Jiho Choi,Aaron J. Huebner,Kendell Clement,Kendell Clement,Ryan M. Walsh,Andrej J. Savol,Kaixuan Lin,Hongcang Gu,Bruno Di Stefano,Justin Brumbaugh,Sang Yong Kim,Jafar Sharif,Christopher M. Rose,Arman W. Mohammad,Junko Odajima,Jean Charron,Toshihiro Shioda,Andreas Gnirke,Steven P. Gygi,Haruhiko Koseki,Ruslan I. Sadreyev,Andrew Xiao,Alexander Meissner,Alexander Meissner,Konrad Hochedlinger +24 more
TL;DR: The data suggest that, although short-term suppression of Mek1/2 in ES cells helps to maintain an ICM-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential.
Journal ArticleDOI
Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells
Yong Jin Choi,Chao Po Lin,Davide Risso,Sean Chen,Thomas Aquinas Kim,Meng How Tan,Jin Billy Li,Yalei Wu,Caifu Chen,Zhenyu Xuan,Todd S. Macfarlan,Weiqun Peng,Kevin C K Lloyd,Sang Yong Kim,Terence P. Speed,Terence P. Speed,Terence P. Speed,Lin He +17 more
TL;DR: In this paper, the miR-34a microRNA (miRNA) was identified as a potent regulator that restricts the cell fate potential of ESCs and iPSCs to a pluripotent state.
Journal ArticleDOI
The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells
Qiong Wang,Yilong Zou,Sonja Nowotschin,Sang Yong Kim,Qing V. Li,Chew-Li Soh,Jie Su,Chao Zhang,Weiping Shu,Qiaoran Xi,Danwei Huangfu,Anna-Katerina Hadjantonakis,Joan Massagué +12 more
TL;DR: An unanticipated role for p53 family proteins is highlighted in a regulatory network that integrates essential Wnt-Tcf and nodal-Smad inputs in a selective and interdependent way to drive mesendodermal differentiation of pluripotent cells.
Journal ArticleDOI
Widespread Transcriptional Scanning in the Testis Modulates Gene Evolution Rates.
Bo Xia,Yun Yan,Maayan Baron,Florian Wagner,Dalia Barkley,Marta Chiodin,Sang Yong Kim,David L. Keefe,Joseph P. Alukal,Jef D. Boeke,Itai Yanai +10 more
TL;DR: It is proposed that transcriptional scanning shapes germline mutation signatures and modulates mutation rates in a gene-specific manner, maintaining DNA sequence integrity for the bulk of genes but allowing for faster evolution in a specific subset.
Journal ArticleDOI
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids
Wei Cao,Hisako Kayama,Mei Lan Chen,Amber Delmas,Amy Sun,Sang Yong Kim,Erumbi S. Rangarajan,Kelly McKevitt,Amanda P. Beck,Cody B. Jackson,Gogce Crynen,Angelos Oikonomopoulos,Precious Lacey,Gustavo J. Martinez,Tina Izard,Robin G. Lorenz,Alexander Rodriguez-Palacios,Fabio Cominelli,Maria T. Abreu,Daniel W. Hommes,Sergei B. Koralov,Kiyoshi Takeda,Mark S. Sundrud +22 more
TL;DR: Effector CD4+ T cells upregulate expression of the xenobiotic transporter, Mdr1, in the ileum to safeguard immune homeostasis, revealing an important immunologic consequence of ileal bile acid reabsorption.