S
Scott C. Weaver
Researcher at University of Texas Medical Branch
Publications - 584
Citations - 40298
Scott C. Weaver is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Virus & Alphavirus. The author has an hindex of 92, co-authored 536 publications receiving 32230 citations. Previous affiliations of Scott C. Weaver include Mount Sinai St. Luke's and Mount Sinai Roosevelt & Lenox Hill Hospital.
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Book ChapterDOI
Genetic diversity and slow rates of evolution in New World alphaviruses.
TL;DR: Alphavirus is a genus of arthropod-borne viruses (arboviruses) in the family Togaviridae that have a single-strand messenger or plus-sense RNA genome of ca.
Journal ArticleDOI
Positively Charged Amino Acid Substitutions in the E2 Envelope Glycoprotein Are Associated with the Emergence of Venezuelan Equine Encephalitis Virus
TL;DR: Analysis of additional E2 sequences implicated similar surface charge changes in the emergence of previous South American epizootic phenotypes, indicating that E2 mutations are probably important determinants of the equine-virulent phenotype and of VEE emergence.
Journal ArticleDOI
Vaccines for Venezuelan equine encephalitis
TL;DR: Some of the older and newer approaches aimed at generating a safe and immunogenic vaccine as well as most recent data about the mechanistic of protection in animal models of infection are reviewed.
Journal ArticleDOI
Capsid protein of eastern equine encephalitis virus inhibits host cell gene expression.
TL;DR: Data suggest that capsid expression from the replicons is ultimately toxic to host cells, presumably because of its ability to inhibit gene expression.
Journal ArticleDOI
Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential
Michael Zasloff,A. Paige Adams,Bernard Beckerman,Ann E. Campbell,Ziying Han,Erik Luijten,Isaura Meza,Justin G. Julander,Abhijit Mishra,Wei Qu,John M. Taylor,Scott C. Weaver,Gerard C. L. Wong +12 more
TL;DR: It is shown that squalamine, a compound previously isolated from the tissues of the dogfish shark and the sea lamprey, exhibits broad-spectrum antiviral activity against human pathogens, which were studied in vitro as well as in vivo.