S
Scott C. Weaver
Researcher at University of Texas Medical Branch
Publications - 584
Citations - 40298
Scott C. Weaver is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Virus & Alphavirus. The author has an hindex of 92, co-authored 536 publications receiving 32230 citations. Previous affiliations of Scott C. Weaver include Mount Sinai St. Luke's and Mount Sinai Roosevelt & Lenox Hill Hospital.
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Journal ArticleDOI
Outbreak of Zika Virus Infection, Chiapas State, Mexico, 2015, and First Confirmed Transmission by Aedes aegypti Mosquitoes in the Americas
Mathilde Guerbois,Ildefonso Fernández-Salas,Sasha R. Azar,Rogelio Danis-Lozano,Celia Alpuche-Aranda,Grace Leal,Iliana R. Garcia-Malo,Esteban E. Díaz-González,Mauricio Casas-Martínez,Shannan L. Rossi,Samanta L. Del Rio-Galvan,Rosa M. Sanchez-Casas,Christopher M. Roundy,Thomas G. Wood,Steven G. Widen,Nikos Vasilakis,Scott C. Weaver +16 more
TL;DR: These results demonstrate the continued, rapid northward progression of ZIKV into North America with typically mild disease manifestations, and implicate A. aegypti for the first time as a principal vector in North America.
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4.4 Å cryo‐EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus
Rui Zhang,Corey F. Hryc,Yao Cong,Xiangan Liu,Joanita Jakana,Rodion Gorchakov,Matthew L. Baker,Scott C. Weaver,Wah Chiu +8 more
TL;DR: Using electron cryo‐microscopy, the structure of an attenuated vaccine strain of VEEV is determined to 4.4 Å resolution, suggesting a mechanism for the initial stage of nucleocapsid core formation and shed light on the virulence attenuation, host recognition and neutralizing activities of V EEV and other alphavirus pathogens.
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Urbanization and geographic expansion of zoonotic arboviral diseases: mechanisms and potential strategies for prevention.
TL;DR: Urban emergences of dengue, chikungunya, and yellow fever viruses and potential strategies for their prevention and control are reviewed.
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Novel Chikungunya Vaccine Candidate with an IRES-Based Attenuation and Host Range Alteration Mechanism
Kenneth S. Plante,Eryu Wang,Charalambos D. Partidos,James Weger,Rodion Gorchakov,Konstantin A. Tsetsarkin,Erin M. Borland,Ann M. Powers,Robert L. Seymour,Dan T. Stinchcomb,Jorge E. Osorio,Ilya Frolov,Scott C. Weaver +12 more
TL;DR: Testing in both normal outbred and interferon response-defective mice indicated that the new vaccine candidate is highly attenuated, immunogenic and efficacious after a single dose, and incapable of replicating in mosquito cells or infecting mosquitoes in vivo.
Posted ContentDOI
Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility.
Jessica A. Plante,Yang Liu,Jianying Liu,Hongjie Xia,Bryan A. Johnson,Kumari G. Lokugamage,Xianwen Zhang,Antonio E. Muruato,Jing Zou,Camila R. Fontes-Garfias,Divya Mirchandani,Dionna Scharton,John P Bilello,Zhiqiang Ku,Zhiqiang An,Birte Kalveram,Alexander N. Freiberg,Vineet D. Menachery,Xuping Xie,Kenneth S. Plante,Scott C. Weaver,Pei Yong Shi +21 more
TL;DR: The D614G mutation significantly enhances SARS-CoV-2 replication on human lung epithelial cells and primary human airway tissues, through an improved infectivity of virions with the spike receptor-binding domain in an “up” conformation for binding to ACE2 receptor.