S
Shinae Kizaka-Kondoh
Researcher at Tokyo Institute of Technology
Publications - 110
Citations - 4936
Shinae Kizaka-Kondoh is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Tumor hypoxia & Gene. The author has an hindex of 36, co-authored 102 publications receiving 4399 citations. Previous affiliations of Shinae Kizaka-Kondoh include Kyoto University.
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Journal ArticleDOI
Tumor hypoxia : A target for selective cancer therapy
TL;DR: Progress is described on the biological aspects of tumor hypoxia and a compilation of the recent molecular approaches used to target hypoxic tumors is provided, including a work with a unique Hypoxia‐targeting protein drug, TOP3, with which to address the above three difficulties.
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Single-cell bioluminescence imaging of deep tissue in freely moving animals
Satoshi Iwano,Mayu Sugiyama,Hiroshi Hama,Akiya Watakabe,Naomi Hasegawa,Takahiro Kuchimaru,Kazumasa Z. Tanaka,Megumu Takahashi,Yoko Ishida,Jun-ichi Hata,Satoshi Shimozono,Kana Namiki,Takashi Fukano,Masahiro Kiyama,Hideyuki Okano,Shinae Kizaka-Kondoh,Thomas J. McHugh,Tetsuo Yamamori,Hiroyuki Hioki,Shojiro Maki,Atsushi Miyawaki +20 more
TL;DR: AkaBLI produced emissions in vivo that were brighter by a factor of 100 to 1000 than conventional systems, allowing noninvasive visualization of single cells deep inside freely moving animals, and is therefore a bioengineered light source to spur unprecedented scientific, medical, and industrial applications.
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Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer
TL;DR: Tumor-associated hypoxia and HIF-1 expression promote the progression of bone metastases in breast cancer by suppressing osteoblast differentiation and promoting osteoclastogenesis.
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Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling
Kenji Kasuno,Kenji Kasuno,Satoshi Takabuchi,Kazuhiko Fukuda,Shinae Kizaka-Kondoh,Junji Yodoi,Junji Yodoi,Takehiko Adachi,Gregg L. Semenza,Kiichi Hirota +9 more
TL;DR: It is concluded that the NO donor NOC18 induces Hif-1α synthesis under conditions of NO formation during normoxia and that hydroxylation of HIF-1 α is not regulated by NOC 18.
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Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia
TL;DR: The significance of pimonidazole and HIF‐1 as exogenous and endogenous hypoxia markers, respectively, as well as their evaluation and imaging of tumorHypoxia are discussed, particularly in the therapy against refractory cancers.