S
Siew Loon Ooi
Researcher at Fred Hutchinson Cancer Research Center
Publications - 16
Citations - 7133
Siew Loon Ooi is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Gene & Chromatin. The author has an hindex of 15, co-authored 16 publications receiving 6704 citations. Previous affiliations of Siew Loon Ooi include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Functional profiling of the Saccharomyces cerevisiae genome.
Guri Giaever,Angela M. Chu,Li Ni,Carla Connelly,Linda Riles,Steeve Veronneau,Sally Dow,Ankuta Lucau-Danila,Keith Anderson,Bruno André,Adam P. Arkin,Anna Astromoff,Mohamed El Bakkoury,Rhonda Bangham,Rocío Benito,Sophie Brachat,Stefano Campanaro,Matt Curtiss,Karen Davis,Adam M. Deutschbauer,K. D. Entian,Patrick Flaherty,Françoise Foury,David J. Garfinkel,Mark Gerstein,Deanna Gotte,Ulrich Güldener,Johannes H. Hegemann,Svenja Hempel,Zelek S. Herman,Daniel F. Jaramillo,Diane E. Kelly,Steven L. Kelly,Peter Kötter,Darlene LaBonte,David C. Lamb,Ning Lan,Hong Liang,Hong Liao,Lucy Y. Liu,Chuanyun Luo,Marc Lussier,Rong Mao,Patrice Menard,Siew Loon Ooi,José L. Revuelta,Christopher J. Roberts,Matthias Rose,Petra Ross-Macdonald,Bart Scherens,Greg Schimmack,Brenda Shafer,Daniel D. Shoemaker,Sharon Sookhai-Mahadeo,Reginald Storms,Jeffrey N. Strathern,Giorgio Valle,Marleen Voet,Guido Volckaert,Ching Yun Wang,Teresa R. Ward,Julie Wilhelmy,Elizabeth A. Winzeler,Yonghong Yang,Grace Yen,Elaine M. Youngman,Kexin Yu,Howard Bussey,Jef D. Boeke,Michael Snyder,Peter Philippsen,Ronald W. Davis,Mark Johnston +72 more
TL;DR: It is shown that previously known and new genes are necessary for optimal growth under six well-studied conditions: high salt, sorbitol, galactose, pH 8, minimal medium and nystatin treatment, and less than 7% of genes that exhibit a significant increase in messenger RNA expression are also required for optimal Growth in four of the tested conditions.
Journal ArticleDOI
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
Mark Gerstein,Zhi John Lu,Eric L. Van Nostrand,Chao Cheng,Bradley I. Arshinoff,Tao Liu,Kevin Y. Yip,R. Robilotto,Andreas Rechtsteiner,Kohta Ikegami,P. Alves,A. Chateigner,Marc D. Perry,Mitzi Morris,Raymond K. Auerbach,X. Feng,Jing Leng,A. Vielle,Wei Niu,Kahn Rhrissorrakrai,Ashish Agarwal,Roger P. Alexander,Galt P. Barber,Cathleen M. Brdlik,J. Brennan,Jeremy Brouillet,Adrian Carr,Ming Sin Cheung,Hiram Clawson,Sergio Contrino,Luke Dannenberg,Abby F. Dernburg,Arshad Desai,L. Dick,Andréa C. Dosé,Jiang Du,Thea A. Egelhofer,Sevinc Ercan,Ghia Euskirchen,Brent Ewing,Elise A. Feingold,Reto Gassmann,Peter J. Good,Philip Green,Francois Gullier,M. Gutwein,Mark S. Guyer,Lukas Habegger,Ting Han,Jorja G. Henikoff,Stefan R. Henz,Angie S. Hinrichs,H. Holster,Tony Hyman,A. Leo Iniguez,J. Janette,M. Jensen,Masaomi Kato,W. James Kent,E. Kephart,Vishal Khivansara,Ekta Khurana,John Kim,P. Kolasinska-Zwierz,Eric C. Lai,Isabel J. Latorre,Amber Leahey,Suzanna E. Lewis,Paul Lloyd,Lucas Lochovsky,Rebecca F. Lowdon,Yaniv Lubling,Rachel Lyne,Michael J. MacCoss,Sebastian D. Mackowiak,Marco Mangone,Sheldon J. McKay,D. Mecenas,Gennifer E. Merrihew,David M. Miller,A. Muroyama,John I. Murray,Siew Loon Ooi,Hoang Pham,T. Phippen,Elicia Preston,Nikolaus Rajewsky,Gunnar Rätsch,Heidi Rosenbaum,Joel Rozowsky,Kim Rutherford,P. Ruzanov,Mihail Sarov,Rajkumar Sasidharan,Andrea Sboner,P. Scheid,Eran Segal,Hyunjin Shin,C. Shou,Frank J. Slack,C. Slightam,Richard J.H. Smith,William C. Spencer,Eo Stinson,S. Taing,Teruaki Takasaki,D. Vafeados,Ksenia Voronina,Guilin Wang,Nicole L. Washington,Christina M. Whittle,Beijing Wu,Koon-Kiu Yan,Georg Zeller,Z. Zha,Mei Zhong,Xingliang Zhou,Julie Ahringer,Susan Strome,Kristin C. Gunsalus,Gos Micklem,X. Shirley Liu,Valerie Reinke,Stuart K. Kim,LaDeana W. Hillier,Steven Henikoff,Fabio Piano,Michael Snyder,Lincoln Stein,Jason D. Lieb,Robert H. Waterston +130 more
TL;DR: These studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized, providing insights into the organization, structure, and function of the two genomes.
Journal ArticleDOI
Automated cell lineage tracing in Caenorhabditis elegans
Zhirong Bao,John I. Murray,Thomas J. Boyle,Siew Loon Ooi,Matthew J. Sandel,Robert H. Waterston +5 more
TL;DR: A system for automated cell lineage tracing during C. elegans embryogenesis, based on 3D, time-lapse imaging and automated image analysis, that envision that this automation will make it practical to systematically decipher the developmental genes and pathways encoded in the genome of C. aristans.
Journal ArticleDOI
Disparities in breast cancer characteristics and outcomes by race/ethnicity
TL;DR: Using data from 17 population-based cancer registries in the Surveillance, Epidemiology, and End Results (SEER) program, the relationships between race/ethnicity and breast cancer stage, hormone receptor status, treatment, and mortality are evaluated.
Journal ArticleDOI
DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray.
TL;DR: A new synthetic lethality analysis by microarray (SLAM) technique that uses ∼4,600 Saccharomyces cerevisiae haploid deletion mutants with molecular 'bar codes' (TAGs) as 'queries' to identify their redundant and unique biological functions, making it an especially useful method.