Silke Kreitz

TL;DR: It is demonstrated that within 24 h after neutralization of TNF-α, nociceptive CNS activity in the thalamus and somatosensoric cortex, but also the activation of the limbic system, is blocked.

TL;DR: Using genome-wide neuronal-specific RNAi knockdown in Drosophila, a global screen for an innate behavior is reported and hundreds of genes implicated in heat nociception are identified, including the α2δ family calcium channel subunit straightjacket (stj).

TL;DR: A multi-centre comparison of 17 mouse rsfMRI datasets via a common image processing and analysis pipeline is described, reporting the reproducible identification of several large-scale resting-state networks (RSN), including a mouse default-mode network, in the majority of datasets.

TL;DR: These data suggest that response to TNFi depends on brain activity in RA patients, reflecting the subjective perception of disease.

TL;DR: It is proposed that BZDs block the relay of aversive signals through the CEA, in part by local binding to CEAl SST + /PKCδ − neurons and reshaping intra-CEA circuit dynamics.