Soumya Swaminathan

TL;DR: The Commission recommends five priority investments to achieve a tuberculosis-free world within a generation, which answer the question of how countries with high-burden tuberculosis and their development partners should target their future investments.

TL;DR: Molecular diagnostics that include markers for rifampicin resistance alone will be insufficient to identify pre-MDR strains, and incorporation of knowledge of polymorphisms that occur before the emergence of multidrug resistance, particularly katG p.Ser315Thr, into molecular diagnostics should enable targeted treatment of patients with pre-mDR-TB to prevent further development of MDR- TB.

TL;DR: The increasing contribution of these diseases to the overall disease burden across India and the high rate of health loss from them, especially in the less developed low ETL states, highlights the need for focused policy interventions to address this significant cause of disease burden.

TL;DR: Increasing case detection is critical to improving outcomes in India’s TB cascade of care, especially for smear-negative and MDR TB patients.

TL;DR: This review highlights unanswered questions, challenges, recent advances, unresolved operational and technical issues, needs, and opportunities related to tuberculosis diagnostics.