Stanley Nattel

TL;DR: Verapamil promotes AF in normal dogs by promoting multiple circuit reentry, an effect dependent on intact autonomic tone and not shared by diltiazem.

TL;DR: Results point to an important role for S6 valines at positions 402 and 404 in mediating voltage‐dependent block by quinidine and flecainide in mediation of voltage dependence in Kv4.2WT channels.

TL;DR: Diltiazem given during reperfusion reduces infarct size by a mechanism that includes an inhibition of neutrophil accumulation in the post-ischaemic myocardium, and to establish if an interaction with neutrophils is implied.

TL;DR: In the future, antiarrhythmic agents will continue to be used acutely to terminate a broad range of sustained arrhythmias, and the development of molecular electrophysiology will allow for the identification of agents with selected ion channel blocking profiles which may prove efficacious with a lower risk of complications.

TL;DR: Despite the abundant expression of mikr, single‐channel events were rarely observed during action‐potential clamp and 5 μm E‐4031 had no detectable effect on the action potential parameters, confirming that mIKr plays at best a minor role in repolarization of adult mouse cardiomyocytes, probably because the modulatory effects of divalent cations prevent significant mIKR opening under physiological conditions.