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Stanley Nattel
Researcher at Montreal Heart Institute
Publications - 802
Citations - 72437
Stanley Nattel is an academic researcher from Montreal Heart Institute. The author has contributed to research in topics: Atrial fibrillation & Heart failure. The author has an hindex of 132, co-authored 778 publications receiving 65700 citations. Previous affiliations of Stanley Nattel include Mayo Clinic & Brigham and Women's Hospital.
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Journal ArticleDOI
Atrial-selective pharmacological therapy for atrial fibrillation: hype or hope?
TL;DR: Efforts to develop atrial-selective antiarrhythmics are bearing fruit, but such compounds will need to exhibit equal or superior safety and efficacy compared with multichannel blockers for atrial fibrillation suppression in order to prove their worth.
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The role of cellular senescence in cardiac disease: basic biology and clinical relevance.
Mozhdeh Mehdizadeh,Mozhdeh Mehdizadeh,Martin Aguilar,Martin Aguilar,Eric Thorin,Eric Thorin,Gerardo Ferbeyre,Stanley Nattel +7 more
TL;DR: A review of the role of cellular senescence in heart disease can be found in this paper, where Nattel et al. discuss the role and potential implications for improving the management of patients with heart disease.
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Dose-Dependence of 4-Aminopyridine Plasma Concentrations and Electrophysiological Effects in Dogs Potential Relevance to Ionic Mechanisms In Vivo
TL;DR: The interpretation of previous studies using intravenous 4AP administration to inhibit I(to) in dogs in vivo needs to be reevaluated in light of the fact that the infusion regimens used produce plasma concentrations that are inadequate to affect ventricular I( to).
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Acute and chronic effects of cardiac resynchronization in patients developing heart failure with long-term pacemaker therapy for acquired complete atrioventricular block.
Masayuki Shimano,Yukiomi Tsuji,Yukihiko Yoshida,Yasuya Inden,Naoya Tsuboi,Teruo Itoh,Hirohiko Suzuki,Takashi Muramatsu,Taro Okada,Shuji Harata,Takumi Yamada,Haruo Hirayama,Stanley Nattel,Stanley Nattel,Toyoaki Murohara +14 more
TL;DR: CRT-upgrade improves the cardiac function and symptoms in CAVB patients with HF progression related to RVA-pacing, and consideration should be given to BiV- and LV- pacing upgrade as soon as possible after the indications appear.
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Properties of potassium currents in Purkinje cells of failing human hearts.
Wei Han,Wei Han,Liming Zhang,Gernot Schram,Gernot Schram,Stanley Nattel,Stanley Nattel,Stanley Nattel +7 more
TL;DR: Human PCs demonstrate a prominent I(K1), a time-dependent hyperpolarization-activated current, and an I(to) with pharmacological sensitivity and recovery kinetics different from those in the atrium or ventricle and compatible with a different molecular basis.