Stanley Nattel

TL;DR: A critical role is established for H3S28 phosphorylation in vivo for life span, stress resistance, cardiac and mitochondrial function in Drosophila, and this findings may pave the way for H 3S28osphorylation as a putative target to treat stress-related disorders such as heart failure.

TL;DR: High-resoluion optical mapping has become a common research tool in asic cardiac electrophysiology, especially in the investigaion of Electrophysiologic mechanisms by which convenional electrical recordings are hampered by inadequate reslution or by a lack of precise information on repolarization.

TL;DR: Novel prognostic, diagnostic and therapeutic strategies for hypertensive diastolic heart failure likely emerge from this work, as genes present in the replaced chromosome segments of the two positive congenic strains are not commonly known to affect blood pressure, diastolics function or left ventricular mass.

TL;DR: Substitution of the Kv4.4 chimeric subunits significantly increased current expression and slowed inactivation without altering the rate of recovery from inactivation, indicating the ability of Kv1.4 subunits to display a variety of properties of K v4.2 N-terminal, including inactivation time-dependence, accelerated recovery from Inactivation and interaction with KChIP2, to Kv 1.4.

TL;DR: Whether an electrogenic INa.Ca is present in adult human atrial myocytes, and if so, whether it contributes to APD is determined.