Stanley Nattel

TL;DR: If drug shortages are here to stay, clinicians, drug manufacturers, and relevant organizations should work together to increase accountability for drug availability and adaptation to shortages, and to create more effective tools with which to anticipate and respond to critical supply fluctuations.

TL;DR: The nature of low-threshold ICa in dog atrium is reexamined, as well as whether it is affected by Na+ channel toxins, to extend the hypothesis of a parallel evolution of Na+ and Ca2+ channels from an ancestor with common structural motifs.

TL;DR: It is found that the propagation failure is highly dependent on the spatial pattern of fibrosis for all conditions studied with maximum sensitivity for patterns with combination of small and large clusters, but the effect is particularly sensitive to reduced sodium current condition where conduction block occurred at lower fibrosis density.

TL;DR: In this paper, the authors focus on rhythm control therapy and explore the challenges that underlie this phenomenon, including regulatory hurdles and considerations and then review industry concerns and strategies, and suggest possible paths for the future.

TL;DR: In this paper, the authors discuss the evidence suggesting a potential bidirectional association between atrial fibrillation and gut microbiota, identifying gut microbiota-derived metabolites as possible regulators of the AF substrate.