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Stanley Nattel
Researcher at Montreal Heart Institute
Publications - 802
Citations - 72437
Stanley Nattel is an academic researcher from Montreal Heart Institute. The author has contributed to research in topics: Atrial fibrillation & Heart failure. The author has an hindex of 132, co-authored 778 publications receiving 65700 citations. Previous affiliations of Stanley Nattel include Mayo Clinic & Brigham and Women's Hospital.
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Journal ArticleDOI
T-Type Calcium Current Contributes to Escape Automaticity and Governs the Occurrence of Lethal Arrhythmias After Atrioventricular Block in Mice
Khai Le Quang,Begoña Benito,Patrice Naud,Xiao Yan Qi,Yan Fen Shi,Jean-Claude Tardif,Marc-Antoine Gillis,Dobromir Dobrev,Flavien Charpentier,Stanley Nattel +9 more
TL;DR: This study suggests that T-type Ca2+ channels play an important role in infranodal escape automaticity and worsens bradycardia-related mortality, increases brady Cardia-associated adverse remodeling, and enhances the risk of malignant ventricular tachyarrhythmias complicating AVB.
Journal ArticleDOI
Acquired delayed rectifier channelopathies: how heart disease and antiarrhythmic drugs mimic potentially-lethal congenital cardiac disorders
TL;DR: An important novel contribution of the Tsuji paper is the convincing demonstration that ventricular I K is downregulation, which points to acquired conditions that may predispose to potentially lethal ventricular tachyarrhythmias while recreating ionic abnormalities associated with congenital LQTSs.
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Atrial Fibrillation and Body Composition: Is it Fat or Lean That Ultimately Determines the Risk?
TL;DR: There is evidence that adipocytes produce biologically active molecules that directly promote the development of Atrial Fibrillation (AF), and there are suggestions that weight loss as part of a structured risk-factor intervention program or as a result of bariatric surgery reduces AF risk.
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Regional Ion Channel Gene Expression Heterogeneity and Ventricular Fibrillation Dynamics in Human Hearts
Gopal Sivagangabalan,Hamed Nazzari,Olivier Bignolais,Ange Maguy,Patrice Naud,Talha Farid,Stéphane Massé,Nathalie Gaborit,András Varró,Krishnakumar Nair,Peter H. Backx,Edward J. Vigmond,Stanley Nattel,Sophie Demolombe,Kumaraswamy Nanthakumar +14 more
TL;DR: Ion channel expression profile in myopathic human hearts is significantly altered compared to normal hearts, and multi-channel ion changes influence VF dynamic in a complex manner not predicted by known single channel linear relationships.
Journal ArticleDOI
Atrial tachycardia induces remodelling of muscarinic receptors and their coupled potassium currents in canine left atrial and pulmonary vein cardiomyocytes
Yung-Hsin Yeh,Yung-Hsin Yeh,Yung-Hsin Yeh,Xiao-Yan Qi,Xiao-Yan Qi,Akiko Shiroshita-Takeshita,Akiko Shiroshita-Takeshita,Liu J,Liu J,Ange Maguy,Ange Maguy,Denis Chartier,Denis Chartier,Terence E. Hébert,Zunzhe Wang,Zunzhe Wang,Stanley Nattel,Stanley Nattel,Stanley Nattel +18 more
TL;DR: This study investigated AT‐induced remodelling of mAChR subtypes and K+‐currents in left‐atrial (LA) and PV cardiomyocytes in atrial fibrillation and found differential cholinergic current responses are a potential underlying mechanism.