M
Michael Chong
Researcher at Population Health Research Institute
Publications - 63
Citations - 2441
Michael Chong is an academic researcher from Population Health Research Institute. The author has contributed to research in topics: Medicine & Mendelian randomization. The author has an hindex of 17, co-authored 41 publications receiving 1465 citations. Previous affiliations of Michael Chong include Laval University & Broad Institute.
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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Rainer Malik,Ganesh Chauhan,Matthew Traylor,Muralidharan Sargurupremraj,Yukinori Okada,Aniket Mishra,Loes C.A. Rutten-Jacobs,Anne-Katrin Giese,Sander W. van der Laan,Solveig Gretarsdottir,Christopher D. Anderson,Michael Chong,Hieab H.H. Adams,Tetsuro Ago,Peter Almgren,Philippe Amouyel,Hakan Ay,Traci M. Bartz,Oscar R. Benavente,Steve Bevan,Giorgio B. Boncoraglio,Robert D. Brown,Adam S. Butterworth,Caty Carrera,Cara L. Carty,Daniel I. Chasman,Wei-Min Chen,John W. Cole,Adolfo Correa,Ioana Cotlarciuc,Carlos Cruchaga,John Danesh,Paul I.W. de Bakker,Anita L. DeStefano,Marcel den Hoed,Qing Duan,Stefan T. Engelter,Guido J. Falcone,Rebecca F. Gottesman,Raji P. Grewal,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Tamara B. Harris,Ahamad Hassan,Aki S. Havulinna,Susan R. Heckbert,Elizabeth G. Holliday,George Howard,Fang-Chi Hsu,Hyacinth I. Hyacinth,M. Arfan Ikram,Erik Ingelsson,Marguerite R. Irvin,Xueqiu Jian,Jordi Jimenez-Conde,Julie A. Johnson,J. Wouter Jukema,Masahiro Kanai,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Charles Kooperberg,Michiaki Kubo,Leslie A. Lange,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Jin-Moo Lee,Robin Lemmens,Didier Leys,Cathryn M. Lewis,Wei-Yu Lin,Arne Lindgren,Erik Lorentzen,Patrik K. E. Magnusson,Jane Maguire,Ani Manichaikul,Patrick F. McArdle,James F. Meschia,Braxton D. Mitchell,Thomas H. Mosley,Mike A. Nalls,Toshiharu Ninomiya,Martin O'Donnell,Bruce M. Psaty,Sara L. Pulit,Kristiina Rannikmäe,Alexander P. Reiner,Kathryn M. Rexrode,Kenneth Rice,Stephen S. Rich,Paul M. Ridker,Natalia S. Rost,Peter M. Rothwell,Jerome I. Rotter,Tatjana Rundek,Ralph L. Sacco,Saori Sakaue,Michèle M. Sale,Veikko Salomaa,Bishwa Raj Sapkota,Reinhold Schmidt,Carsten Oliver Schmidt,Ulf Schminke,Pankaj Sharma,Agnieszka Slowik,Cathie Sudlow,Christian Tanislav,Turgut Tatlisumak,Kent D. Taylor,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Steffen Tiedt,Stella Trompet,Christophe Tzourio,Cornelia M. van Duijn,Matthew Walters,Nicholas J. Wareham,Sylvia Wassertheil-Smoller,James G. Wilson,Kerri L. Wiggins,Qiong Yang,Salim Yusuf,Joshua C. Bis,Tomi Pastinen,Arno Ruusalepp,Eric E. Schadt,Simon Koplev,Johan Björkegren,Veronica Codoni,Mete Civelek,Nicholas L. Smith,David A. Tregouet,Ingrid E. Christophersen,Carolina Roselli,Steven A. Lubitz,Patrick T. Ellinor,E. Shyong Tai,Jaspal S. Kooner,Norihiro Kato,Jiang He,Pim van der Harst,Paul Elliott,John C. Chambers,Fumihiko Takeuchi,Andrew D. Johnson,Dharambir K. Sanghera,Olle Melander,Christina Jern,Daniel Strbian,Israel Fernandez-Cadenas,W. T. Longstreth,Arndt Rolfs,Jun Hata,Daniel Woo,Jonathan Rosand,Guillaume Paré,Jemma C. Hopewell,Danish Saleheen,Kari Stefansson,Bradford B. Worrall,Steven J. Kittner,Sudha Seshadri,Myriam Fornage,Hugh S. Markus,Joanna M. M. Howson,Yoichiro Kamatani,Stéphanie Debette,Martin Dichgans +170 more
TL;DR: A multiancestry genome-wide-association meta-analysis and discovered 22 new stroke risk loci, indicating mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets.
Journal ArticleDOI
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
Amand F. Schmidt,Daniel I. Swerdlow,Daniel I. Swerdlow,Michael V. Holmes,Michael V. Holmes,Riyaz S. Patel,Riyaz S. Patel,Zammy Fairhurst-Hunter,Donald M. Lyall,Fernando Pires Hartwig,Bernardo L. Horta,Elina Hyppönen,Elina Hyppönen,Christine Power,Max Moldovan,Max Moldovan,Erik P A Van Iperen,G. Kees Hovingh,Ilja Demuth,Kristina Norman,Elisabeth Steinhagen-Thiessen,Juri Demuth,Lars Bertram,Lars Bertram,Tian Liu,Stefan Coassin,Johann Willeit,Stefan Kiechl,Karin Willeit,Dan Mason,John Wright,Richard W Morris,Goya Wanamethee,Peter H. Whincup,Yoav Ben-Shlomo,Stela McLachlan,Jackie F. Price,Mika Kivimäki,Catherine Welch,Adelaida Sanchez-Galvez,Pedro Marques-Vidal,Andrew N. Nicolaides,Andrew N. Nicolaides,Andrie G. Panayiotou,N. Charlotte Onland-Moret,Yvonne T. van der Schouw,Giuseppe Matullo,Giovanni Fiorito,Simonetta Guarrera,Carlotta Sacerdote,Nicholas J. Wareham,Claudia Langenberg,Robert A. Scott,Jian'an Luan,Martin Bobak,Sofia Malyutina,Andrzej Pająk,Ruzena Kubinova,Abdonas Tamosiunas,Hynek Pikhart,Lise Lotte N. Husemoen,Niels Grarup,Oluf Pedersen,Torben Hansen,Allan Linneberg,Kenneth Starup Simonsen,Jackie A. Cooper,Steve E. Humphries,Murray H. Brilliant,Terrie Kitchner,Hakon Hakonarson,David Carrell,Catherine A. McCarty,H. Lester Kirchner,Eric B. Larson,David R. Crosslin,Mariza de Andrade,Dan M. Roden,Joshua C. Denny,Cara L. Carty,Stephen Hancock,John Attia,Elizabeth G. Holliday,Martin O'Donnell,Salim Yusuf,Michael Chong,Guillaume Paré,Pim van der Harst,M. Abdullah Said,Ruben N. Eppinga,Niek Verweij,Harold Snieder,Tim Christen,Dennis O. Mook-Kanamori,Stefan Gustafsson,Lars Lind,Erik Ingelsson,Erik Ingelsson,Erik Ingelsson,Raha Pazoki,Oscar H. Franco,Albert Hofman,André G. Uitterlinden,Abbas Dehghan,Abbas Dehghan,Alexander Teumer,Sebastian E. Baumeister,Sebastian E. Baumeister,Marcus Dörr,Markus M. Lerch,Uwe Völker,Henry Völzke,Joey Ward,Jill P. Pell,Daniel J. Smith,Tom W. Meade,Anke H. Maitland-van der Zee,Ekaterina V Baranova,Robin Young,Ian Ford,Archie Campbell,Sandosh Padmanabhan,Michiel L. Bots,Diederick E. Grobbee,Philippe Froguel,Philippe Froguel,Dorothée Thuillier,Beverley Balkau,Amélie Bonnefond,Amélie Bonnefond,Bertrand Cariou,Melissa C. Smart,Yanchun Bao,Meena Kumari,Anubha Mahajan,Paul M. Ridker,Daniel I. Chasman,Alexander P. Reiner,Leslie A. Lange,Marylyn D. Ritchie,Marylyn D. Ritchie,Folkert W. Asselbergs,Juan-Pablo Casas,Brendan J. Keating,David Preiss,David Preiss,Aroon D. Hingorani,Naveed Sattar +147 more
TL;DR: PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes.
Journal ArticleDOI
Loci associated with ischaemic stroke and its subtypes (SiGN) : A genome-wide association study
Sara L. Pulit,Patrick F. McArdle,Quenna Wong,Rainer Malik,Katrina Gwinn,Sefanja Achterberg,Ale Algra,Philippe Amouyel,Christopher D. Anderson,Donna K. Arnett,Ethem Murat Arsava,John Attia,Hakan Ay,Traci M. Bartz,Thomas W.K. Battey,Oscar R. Benavente,Steve Bevan,Alessandro Biffi,Joshua C. Bis,Susan H. Blanton,Giorgio B. Boncoraglio,Robert D. Brown,Annette I. Burgess,Caty Carrera,Sherita N Chapman Smith,Daniel I. Chasman,Ganesh Chauhan,Wei-Min Chen,Yu-Ching Cheng,Michael Chong,Lisa Cloonan,John W. Cole,Ioana Cotlarciuc,Carlos Cruchaga,Elisa Cuadrado-Godia,Tushar Dave,Jesse Dawson,Stéphanie Debette,Hossein Delavaran,Cameron A Dell,Martin Dichgans,Kimberly F. Doheny,Chuanhui Dong,David Duggan,Gunnar Engström,Michele K. Evans,Xavier Estivill Pallejà,Jessica D. Faul,Israel Fernandez-Cadenas,Myriam Fornage,Philippe M. Frossard,Karen L. Furie,Dale M Gamble,Christian Gieger,Anne-Katrin Giese,Eva Giralt-Steinhauer,Hector M. González,An Goris,Solveig Gretarsdottir,Raji P. Grewal,Ulrike Grittner,Stefan Gustafsson,Buhm Han,Graeme J. Hankey,Laura Heitsch,Peter Higgins,Marc C. Hochberg,Elizabeth G. Holliday,Jemma C. Hopewell,Richard B. Horenstein,George Howard,M. Arfan Ikram,Andreea Ilinca,Erik Ingelsson,Marguerite R. Irvin,Rebecca D. Jackson,Christina Jern,Jordi Jimenez Conde,Julie A. Johnson,Katarina Jood,Muhammad S Kahn,Robert C. Kaplan,L. Jaap Kappelle,Sharon L.R. Kardia,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Simon A. Koblar,Daniel L. Labovitz,Lenore J. Launer,Cathy C. Laurie,Cecelia A. Laurie,Cue Hyunkyu Lee,Jin-Moo Lee,Manuel Lehm,Robin Lemmens,Christopher Levi,Didier Leys,Arne Lindgren,W. T. Longstreth,Jane Maguire,Ani Manichaikul,Hugh S. Markus,Leslie A. McClure,Caitrin W. McDonough,Christa Meisinger,Olle Melander,James F. Meschia,Marina Mola-Caminal,Joan Montaner,Thomas H. Mosley,Martina Müller-Nurasyid,Mike A. Nalls,Jeffrey R. O'Connell,Martin O'Donnell,Angel Ois,George J. Papanicolaou,Guillaume Paré,Leema Reddy Peddareddygari,Annie Pedersen,Joanna Pera,Annette Peters,D Poole,Bruce M. Psaty,Raquel Rabionet,Miriam R. Raffeld,Kristiina Rannikmäe,Asif Rasheed,Petra Redfors,Alexander P. Reiner,Kathryn M. Rexrode,Marta Ribasés,Stephen S. Rich,Wim Robberecht,Ana Rodríguez-Campello,Arndt Rolfs,Jaume Roquer,Lynda M. Rose,Daniel Rosenbaum,Natalia S. Rost,Peter M. Rothwell,Tatjana Rundek,Kathleen A. Ryan,Ralph L. Sacco,Michèle M. Sale,Danish Saleheen,Veikko Salomaa,Cristina Sánchez-Mora,Carsten Oliver Schmidt,Helena Schmidt,Reinhold E. Schmidt,Markus Schürks,Rodney J. Scott,Helen Segal,Stephan Seiler,Sudha Seshadri,Pankaj Sharma,Alan R. Shuldiner,Brian Silver,Agnieszka Slowik,Jennifer A. Smith,Martin Söderholm,Carolina Soriano,Mary J. Sparks,Tara M. Stanne,Kari Stefansson,O. Colin Stine,Konstantin Strauch,Jonathan Sturm,Cathie Sudlow,Salman M. Tajuddin,Robert L. Talbert,Turgut Tatlisumak,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteindottir,Steffen Tiedt,Matthew Traylor,Stella Trompet,Valerie Valant,Melanie Waldenberger,Matthew Walters,Liyong Wang,Sylvia Wassertheil-Smoller,David R. Weir,Kerri L. Wiggins,Stephen R. Williams,Dorota Wloch-Kopec,Daniel Woo,Rebecca Woodfield,Ona Wu,Huichun Xu,Alan B. Zonderman,Bradford B. Worrall,Paul I.W. de Bakker,Steven J. Kittner,Braxton D. Mitchell,Jonathan Rosand,Cathie L. M. Sudlow,Bradford B. Worrall,Donna K. Arnett,Oscar R. Benavente,Sylvia Wasssertheil-Smoller +202 more
TL;DR: A novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke was identified and supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies.
Journal ArticleDOI
Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy
Bongani M. Mayosi,Maryam Fish,Gasnat Shaboodien,Elisa Mastantuono,Sarah Kraus,Thomas Wieland,Maria Christina Kotta,Ashley Chin,Nakita Laing,Ntobeko B A Ntusi,Michael Chong,Christopher Horsfall,Simon N. Pimstone,Davide Gentilini,Gianfranco Parati,Tim Matthias Strom,Tim Matthias Strom,Thomas Meitinger,Guillaume Paré,Peter J. Schwartz,Lia Crotti +20 more
TL;DR: The data implicate CDH2 mutations as novel genetic causes of ARVC and contribute to a more complete identification of disease genes involved in cardiomyopathy.
Journal ArticleDOI
Body mass index is negatively associated with telomere length : a collaborative cross-sectional meta-analysis of 87 observational studies
Marij Gielen,Geja J. Hageman,Evangelia Antoniou,Katarina Nordfjäll,Massimo Mangino,Muthuswamy Balasubramanyam,Tim De Meyer,Audrey E. Hendricks,Audrey E. Hendricks,Erik J. Giltay,Steven C. Hunt,Jennifer A. Nettleton,Klelia D. Salpea,Vanessa A. Diaz,Ramin Farzaneh-Far,Gil Atzmon,Sarah E. Harris,Lifang Hou,David Gilley,Iiris Hovatta,Iiris Hovatta,Jeremy D. Kark,Hisham Nassar,David J. Kurz,Karen A. Mather,Peter Willeit,Yun-Ling Zheng,Sofia Pavanello,Ellen W. Demerath,Line Rode,Daniel Bunout,Andrew Steptoe,Lisa A. Boardman,Amelia Marti,Amelia Marti,Belinda L. Needham,Wei Zheng,Rosalind Ramsey-Goldman,Andrew J. Pellatt,Jaakko Kaprio,Jonathan N. Hofmann,Christian Gieger,Giuseppe Paolisso,Jacob B. H. Hjelmborg,Lisa Mirabello,Teresa E. Seeman,Jason Y.Y. Wong,Pim van der Harst,Linda Broer,Florian Kronenberg,Barbara Kollerits,Timo E. Strandberg,Daniel Eisenberg,Catherine Duggan,Josine E. Verhoeven,Roxanne Schaakxs,Raffaela Zannolli,Rosana Maria dos Reis,Fadi J. Charchar,Maciej Tomaszewski,Maciej Tomaszewski,Ute Mons,Ilja Demuth,Andrea Elena Iglesias Molli,Guo Cheng,Dmytro Krasnienkov,Bianca D’Antono,Marek Kasielski,Barry J. McDonnell,Richard P. Ebstein,Kristina Sundquist,Guillaume Paré,Michael Chong,Maurice P. Zeegers +73 more
TL;DR: In this paper, a collaborative cross-sectional meta-analysis of observational studies was conducted to investigate the associations between BMI and leukocyte telomere length across the life span.