D Poole

TL;DR: A new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 is identified, which suggests distinct genetic architectures for different stroke subtypes.

TL;DR: The authors conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry, and identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.

TL;DR: A novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke was identified and supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies.

TL;DR: The results indicate an association between common variation in the COL4A2 gene and symptomatic small vessel disease, particularly deep intracerebral hemorrhage, and merit replication studies, including in ethnic groups of non-European ancestry.

TL;DR: There have been no population‐based studies in unselected patients with transient ischaemic attack (TIA) or stroke across the full range of ages, and the prevalence of FD has been reported to be up to 4% in cryptogenic young stroke patients.