F
Frank E. Nargang
Researcher at University of Alberta
Publications - 73
Citations - 4994
Frank E. Nargang is an academic researcher from University of Alberta. The author has contributed to research in topics: Neurospora crassa & TIM/TOM complex. The author has an hindex of 38, co-authored 73 publications receiving 4886 citations. Previous affiliations of Frank E. Nargang include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism
Katherine A. Borkovich,Lisa A. Alex,Oded Yarden,Michael Freitag,Gloria E. Turner,Nick D. Read,Stephan Seiler,Deborah Bell-Pedersen,John V. Paietta,Nora Plesofsky,Michael Plamann,Marta Goodrich-Tanrikulu,Ulrich Schulte,Gertrud Mannhaupt,Frank E. Nargang,Alan Radford,Claude P. Selitrennikoff,James E. Galagan,Jay C. Dunlap,Jennifer J. Loros,David E. A. Catcheside,Hirokazu Inoue,Rodolfo Aramayo,Michael Polymenis,Eric U. Selker,Matthew S. Sachs,George A. Marzluf,Ian T. Paulsen,Rowland H. Davis,Daniel J. Ebbole,Alex Zelter,Eric R. Kalkman,Rebecca O’Rourke,Frederick J. Bowring,Jane Yeadon,Chizu Ishii,Keiichiro Suzuki,Wataru Sakai,Robert Pratt +38 more
TL;DR: An analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa reveals potential new targets for antifungals as well as loci implicated in human and plant physiology and disease.
Journal ArticleDOI
The Preprotein Translocation Channel of the Outer Membrane of Mitochondria
Klaus-Peter Künkele,Susanne Heins,Markus Dembowski,Frank E. Nargang,Roland Benz,Michel Thieffry,Jochen Walz,Roland Lill,Stephan Nussberger,Walter Neupert +9 more
TL;DR: The structure reported here represents the protein-conducting channel of the mitochondrial outer membrane of mitochondria, which mediates integration of proteins into and translocation across the lipid bilayer.
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The TOM core complex: the general protein import pore of the outer membrane of mitochondria.
Uwe Ahting,Clemens Thun,Reiner Hegerl,Dieter Typke,Frank E. Nargang,Walter Neupert,Stephan Nussberger +6 more
TL;DR: The TOM core complex of Neurospora crassa is isolated by removing the receptors Tom70 and Tom20 from the isolated TOM holo complex by treatment with the detergent dodecyl maltoside, which consists of Tom40, Tom22, and the small Tom components, Tom6 and Tom7.
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Tim50, a novel component of the TIM23 preprotein translocase of mitochondria
Dejana Mokranjac,Stefan A. Paschen,Christian Kozany,Holger Prokisch,Suzanne Hoppins,Frank E. Nargang,Walter Neupert,Kai Hell +7 more
TL;DR: It is suggested that Tim50 plays a crucial role in the transfer of preproteins from the TOM complex to the TIM23 complex through the intermembrane space.
Journal ArticleDOI
The Tim8-Tim13 Complex of Neurospora crassa Functions in the Assembly of Proteins into Both Mitochondrial Membranes
Suzanne Hoppins,Frank E. Nargang +1 more
TL;DR: The isolated tim8 and tim13 mutants in Neurospora crassa are isolated and it is shown that mitochondria lacking the Tim8-Tim13 complex were deficient in the import of the outer membrane β-barrel proteins Tom40 and porin.