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Suet Yi Leung
Researcher at University of Hong Kong
Publications - 252
Citations - 34944
Suet Yi Leung is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 68, co-authored 239 publications receiving 32462 citations. Previous affiliations of Suet Yi Leung include University of Missouri & Queen Mary University of London.
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Journal ArticleDOI
Mutations of the BRAF gene in human cancer
Helen Davies,Graham R. Bignell,Charles Cox,Philip J. Stephens,Sarah Edkins,S. M. Clegg,Jon W. Teague,Hayley Woffendin,Mathew J. Garnett,William Bottomley,Neil Davis,Ed Dicks,Rebecca Ewing,Yvonne Floyd,Kristian Gray,S. Hall,Rachel Hawes,Jaime Hughes,Vivian Kosmidou,Andrew Menzies,Catherine Mould,Adrian Parker,Claire Stevens,Stephen Watt,Steven Hooper,Rebecca Wilson,Hiran Jayatilake,Barry A. Gusterson,Colin Cooper,Janet Shipley,Darren Hargrave,Kathy Pritchard-Jones,Norman J. Maitland,Georgia Chenevix-Trench,Gregory J. Riggins,Darell D. Bigner,Giuseppe Palmieri,Antonio Cossu,Adrienne M. Flanagan,Andrew G. Nicholson,Judy W. C. Ho,Suet Yi Leung,Siu Tsan Yuen,Barbara L. Weber,Hilliard F. Seigler,Timothy L. Darrow,Hugh Paterson,Richard Marais,Christopher J. Marshall,Richard Wooster,Michael R. Stratton,P. Andrew Futreal +51 more
TL;DR: BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%.
Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Journal ArticleDOI
MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma
Aaron J. Schetter,Suet Yi Leung,Jane J. Sohn,Krista A. Zanetti,Elise D. Bowman,Nozomu Yanaihara,Siu Tsan Yuen,Tsun Leung Chan,Dora L.W. Kwong,Gordon K.H. Au,Chang Gong Liu,George A. Calin,Carlo M. Croce,Curtis C. Harris +13 more
TL;DR: expression patterns of microRNAs are systematically altered in colon adenocarcinomas and high miR-21 expression is associated with poor survival and poor therapeutic outcome.
Journal ArticleDOI
Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats
Susanna K. P. Lau,Patrick C. Y. Woo,Kenneth S. M. Li,Yi Huang,Hoi-Wah Tsoi,Beatrice H.L. Wong,Samson S. Y. Wong,Suet Yi Leung,Kwok-Hung Chan,Kwok-Yung Yuen +9 more
TL;DR: In a surveillance study for CoV in noncaged animals from the wild areas of the Hong Kong Special Administration Region, a CoV closely related to SARS-CoV is identified from 23 (39%) of 59 anal swabs of wild Chinese horseshoe bats by using RT-PCR and the presence of a 29-bp insertion in ORF 8 of bat-SARS- coV genome suggests that it has a common ancestor with civet SARS -CoV.
Journal ArticleDOI
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
Benjamin C.Y. Wong,Shiu Kum Lam,Wai Man Wong,Jian Shun Chen,Ting Ting Zheng,Rui E. Feng,Kam Chuen Lai,Wayne Hsing Cheng Hu,Siu Tsan Yuen,Suet Yi Leung,Daniel Y. T. Fong,Joanna Ho,Chi Kong Ching,Jun Shi Chen +13 more
TL;DR: It was found that the incidence of gastric cancer development at the population level was similar between participants receiving H pylori eradication treatment and those receiving placebo during a period of 7.5 years in a high-risk region of China.