S
Swati Choudhary
Researcher at Copenhagen University Hospital
Publications - 12
Citations - 351
Swati Choudhary is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Circulating tumor cell & Cancer cell. The author has an hindex of 5, co-authored 12 publications receiving 228 citations. Previous affiliations of Swati Choudhary include Indian Institute of Technology Madras.
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Journal ArticleDOI
The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
Mette Ø. Agerbæk,Mette Ø. Agerbæk,Mette Ø. Agerbæk,Sara R. Bang-Christensen,Ming-Hsin Yang,Ming-Hsin Yang,Thomas Mandel Clausen,Thomas Mandel Clausen,Thomas Mandel Clausen,Marina Ayres Pereira,Shreya Sharma,Sisse B. Ditlev,Morten Nielsen,Swati Choudhary,Tobias Gustavsson,Poul H. Sorensen,Tim Meyer,David Propper,Jonathan Shamash,Thor G. Theander,Alexandra Aicher,Mads Daugaard,Mads Daugaard,Christopher Heeschen,Christopher Heeschen,Ali Salanti +25 more
TL;DR: It is shown that rVAR2 efficiently captures CTCs from hepatic, lung, pancreatic, and prostate carcinoma patients with minimal contamination of peripheral blood mononuclear cells and targets a larger and more diverse population of C TCs compared to anti-EpCAM strategies.
Journal ArticleDOI
Therapeutic potential of anticancer immunotoxins.
TL;DR: This review elaborates the key findings of the important clinical studies relating to various chimeric toxins and identifies the only FDA-approved immunotoxin in the world.
Journal ArticleDOI
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity.
Cyrielle Fougeroux,Louise Goksøyr,Manja Idorn,Vladislav Soroka,Sebenzile K. Myeni,Robert Dagil,Christoph M. Janitzek,Max Søgaard,Kara Lee Aves,Emma W. Horsted,Sayit Mahmut Erdoğan,Sayit Mahmut Erdoğan,Tobias Gustavsson,Jerzy Dorosz,Stine B. Clemmensen,Laurits Fredsgaard,Susan Thrane,Elena Ethel Vidal-Calvo,Paul Khalifé,Thomas M. Hulen,Swati Choudhary,Michael Theisen,Susheel K. Singh,Asier Garcia-Senosiain,Linda van Oosten,Gorben P. Pijlman,Bettina Hierzberger,Tanja Domeyer,Blanka W. Nalewajek,Anette Strøbæk,Magdalena Skrzypczak,Laura F. Andersson,Søren Buus,Anette Stryhn Buus,Jan Pravsgaard Christensen,Tim J. Dalebout,Kasper Iversen,Lene Holm Harritshøj,Benjamin Mordmüller,Henrik Ullum,Line S. Reinert,Willem A. de Jongh,Marjolein Kikkert,Søren R. Paludan,Thor G. Theander,Morten Nielsen,Ali Salanti,Adam F. Sander +47 more
TL;DR: In this paper, two capsid-like particle (CLP)-based vaccines displaying the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein were developed.
Journal ArticleDOI
Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein.
Sara R. Bang-Christensen,Rasmus S Pedersen,Marina Ayres Pereira,Thomas Mandel Clausen,Caroline Løppke,Nicolai T Sand,Theresa D Ahrens,Amalie M. Jørgensen,Yi Chieh Lim,Louise Goksøyr,Swati Choudhary,Tobias Gustavsson,Robert Dagil,Mads Daugaard,Adam F. Sander,Mathias H. Torp,Max Søgaard,Thor G. Theander,Olga Østrup,Ulrik Lassen,Petra Hamerlik,Ali Salanti,Mette Ø. Agerbæk +22 more
TL;DR: This article demonstrates how the recombinant malaria VAR2CSA protein (rVAR2) can be used for the capture and detection of glioma cell lines that are spiked into blood through binding to a cancer-specific oncofetal chondroitin sulfate ( ofCS).
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Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Kaituo Wang,Robert Dagil,Thomas Lavstsen,Sandeep K. Misra,Charlotte B Spliid,Charlotte B Spliid,Yong Wang,Tobias Gustavsson,Daniel R. Sandoval,Elena Ethel Vidal-Calvo,Swati Choudhary,Mette Ø. Agerbæk,Kresten Lindorff-Larsen,Morten Nielsen,Thor G. Theander,Joshua S. Sharp,Thomas Mandel Clausen,Pontus Gourdon,Ali Salanti +18 more
TL;DR: Cryo-EM structures of the VAR2CSA ectodomain are reported at up to 3.1 Å resolution revealing an overall V-shaped architecture and a complex domain organization that will support rational design of second-generation placental malaria vaccines.