T
T.D. Tran
Researcher at University of Utah
Publications - 15
Citations - 3471
T.D. Tran is an academic researcher from University of Utah. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 10, co-authored 15 publications receiving 3364 citations.
Papers
More filters
Journal ArticleDOI
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
Richard Wooster,Susan L. Neuhausen,Jonathan Mangion,Yvette Quirk,D Ford,N. Collins,K. Nguyen,Sheila Seal,T.D. Tran,D. Averill,P Fields,Gill Marshall,Steven A. Narod,Gilbert M. Lenoir,Henry T. Lynch,Jean Feunteun,Peter Devilee,Cees J. Cornelisse,Fred H. Menko,Peter A. Daly,Wilma Ormiston,Ross McManus,Carole Pye,Cathryn M. Lewis,Lisa A. Cannon-Albright,Julian Peto,Bruce A.J. Ponder,Mark H. Skolnick,Douglas F. Easton,David E. Goldgar,Michael R. Stratton +30 more
TL;DR: This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13, which preliminary evidence suggests suggests confers a high risk of breast cancer but does not confer a substantially elevated risk of ovarian cancer.
Journal ArticleDOI
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
Sean V. Tavtigian,Jacques Simard,Johanna M. Rommens,Fergus J. Couch,Donna M Shattuck-Eidens,Susan L. Neuhausen,Sofia D. Merajver,Steinunn Thorlacius,Kenneth Offit,Dominique Stoppa-Lyonnet,Carole Bélanger,Russell Bell,Simin Berry,Robert Bogden,Qian Chen,Thaylon Davis,Martine Dumont,Cheryl Frye,T. Hattier,Srikanth Jammulapati,Teresa Janecki,Ping Jiang,Robert Kehrer,J.-F. Leblanc,J.T. Mitchell,Jodi Mcarthur-Morrison,K. Nguyen,Yi Peng,Chantal Samson,Marianne Schroeder,S.C. Snyder,Linda Steele,M. Stringfellow,C. Stroup,Bradley D. Swedlund,J. Swense,David H. F. Teng,Alun Thomas,T.D. Tran,Martine Tranchant,Jane Weaver-Feldhaus,Alexander K. C. Wong,Hiroaki Shizuya,Jorunn E. Eyfjord,Lisa A. Cannon-Albright,Fernand Labrie,Mark H. Skolnick,Mark H. Skolnick,Barbara L. Weber,Alexander Kamb,David E. Goldgar,David E. Goldgar +51 more
TL;DR: The complete coding sequence and exonic structure of BRCA2 is determined, and its pattern of expression is examined, and a mutational analysis of B RCA2 in families selected on the basis of linkage analysis and/or the presence of one or more cases of male breast cancer is reported.
Journal ArticleDOI
Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer.
Susan L. Neuhausen,Teresa Gilewski,Larry Norton,T.D. Tran,Peter McGuire,Jeff Swensen,Heather Hampel,Patrick I. Borgen,Karen T. Brown,Mark H. Skolnick,Mark H. Skolnick,Donna M Shattuck-Eidens,Suresh C. Jhanwar,David E. Goldgar,Kenneth Offit +14 more
TL;DR: The results of this report suggest that a recurrent mutation of BRCA1 and a recurrent mutations ofBRCA2 together may account for over a quarter of all early-onset breast cancer cases and two thirds of early-ONSet breastcancer in the setting of a personal or family history of ovarian cancer in Ashkenazi Jewish women.
Journal ArticleDOI
A Large Kindred With 17q-Linked Breast and Ovarian Cancer: Genetic, Phenotypic, and Genealogical Analysis
David E. Goldgar,P Fields,Cathryn M. Lewis,T.D. Tran,Lisa A. Cannon-Albright,John H. Ward,Jeff Swensen,Mark H. Skolnick +7 more
TL;DR: The mutation appears to confer a lower risk of cancer at younger ages than found in previous studies, and will be useful in longitudinal follow-up studies and in studies of the psychosocial implications of providing DNA diagnosis of BRCA1.
Journal ArticleDOI
Inheritance of proliferative breast disease in breast cancer kindreds
Mark H. Skolnick,Lisa A. Cannon-Albright,David E. Goldgar,John H. Ward,C J Marshall,G. B. Schumann,H. Hogle,William P. Mcwhorter,E.C. Wright,T.D. Tran,D. T. Bishop,James P. Kushner,Harmon J. Eyre +12 more
TL;DR: The hypothesis that genetic susceptibility for Proliferative breast disease is responsible for a considerable portion of breast cancer, including unilateral and postmenopausal breast cancer is supported.