T
Tao Huang
Researcher at Chinese Academy of Sciences
Publications - 325
Citations - 12593
Tao Huang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 41, co-authored 248 publications receiving 10196 citations. Previous affiliations of Tao Huang include CAS-MPG Partner Institute for Computational Biology & Shanghai Mental Health Center.
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The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
Kristin G. Ardlie,David S. DeLuca,Ayellet V. Segrè,Timothy J. Sullivan,Taylor Young,Ellen Gelfand,Casandra A. Trowbridge,Julian Maller,Taru Tukiainen,Monkol Lek,Lucas D. Ward,Pouya Kheradpour,Benjamin Iriarte,Yan Meng,Cameron D. Palmer,Tõnu Esko,Wendy Winckler,Joel N. Hirschhorn,Manolis Kellis,Daniel G. MacArthur,Gad Getz,Andrey A. Shabalin,Gen Li,Yi-Hui Zhou,Andrew B. Nobel,Ivan Rusyn,Fred A. Wright,Tuuli Lappalainen,Pedro G. Ferreira,Halit Ongen,Manuel A. Rivas,Alexis Battle,Sara Mostafavi,Jean Monlong,Michael Sammeth,Marta Melé,Ferran Reverter,Jakob M. Goldmann,Daphne Koller,Roderic Guigó,Mark I. McCarthy,Emmanouil T. Dermitzakis,Eric R. Gamazon,Hae Kyung Im,Anuar Konkashbaev,Dan L. Nicolae,Nancy J. Cox,Timothée Flutre,Xiaoquan Wen,Matthew Stephens,Jonathan K. Pritchard,Zhidong Tu,Bin Zhang,Tao Huang,Quan Long,Luan Lin,Jialiang Yang,Jun Zhu,Jun Liu,Amanda Brown,Bernadette Mestichelli,Denee Tidwell,Edmund Lo,Mike Salvatore,Saboor Shad,Jeffrey A. Thomas,John T. Lonsdale,Michael T. Moser,Bryan Gillard,Ellen Karasik,Kimberly Ramsey,Christopher Choi,Barbara A. Foster,John Syron,Johnell Fleming,Harold Magazine,Rick Hasz,Gary Walters,Jason Bridge,Mark Miklos,Susan L. Sullivan,Laura Barker,Heather M. Traino,Maghboeba Mosavel,Laura A. Siminoff,Dana R. Valley,Daniel C. Rohrer,Scott D. Jewell,Philip A. Branton,Leslie H. Sobin,Mary Barcus,Liqun Qi,Jeffrey McLean,Pushpa Hariharan,Ki Sung Um,Shenpei Wu,David Tabor,Charles Shive,Anna M. Smith,Stephen A. Buia,Anita H. Undale,Karna Robinson,Nancy Roche,Kimberly M. Valentino,Angela Britton,Robin Burges,Debra Bradbury,Kenneth W. Hambright,John Seleski,Greg E. Korzeniewski,Kenyon Erickson,Yvonne Marcus,Jorge Tejada,Mehran Taherian,Chunrong Lu,Margaret J. Basile,Deborah C. Mash,Simona Volpi,Jeffery P. Struewing,Gary F. Temple,Joy T. Boyer,Deborah Colantuoni,Roger Little,Susan E. Koester,Latarsha J. Carithers,Helen M. Moore,Ping Guan,Carolyn C. Compton,Sherilyn Sawyer,Joanne P. Demchok,Jimmie B. Vaught,Chana A. Rabiner,Nicole C. Lockhart +132 more
TL;DR: The landscape of gene expression across tissues is described, thousands of tissue-specific and shared regulatory expression quantitative trait loci (eQTL) variants are cataloged, complex network relationships are described, and signals from genome-wide association studies explained by eQTLs are identified.
Journal ArticleDOI
Correction: Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases
Jialiang Yang,Tao Huang,Francesca Petralia,Quan Long,Bin Zhang,Carmen Argmann,Yong Zhao,Charles V. Mobbs,Eric E. Schadt,Jun Zhu,Zhidong Tu +10 more
TL;DR: This work catalogueed age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project, finding the aging gene expression signatures are very tissue specific and enrichment for some well-known aging components such as mitochondrial biology is observed in many tissues.
Journal ArticleDOI
Promises and Challenges of Big Data Computing in Health Sciences
TL;DR: The latest applications of Big Data in health sciences, including the recommendation systems in healthcare, Internet-based epidemic surveillance, sensor-based health conditions and food safety monitoring, Genome-Wide Association Studies (GWAS) and expression Quantitative Trait Loci (eQTL), inferring air quality using big data and metabolomics and ionomics for nutritionists are summarized.
Journal ArticleDOI
Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways
TL;DR: This study investigated the essential and non-essential genes reported in a previous study and extracted gene ontology (GO) terms and biological pathways that are important for the determination of essential genes, and suggests that this study provides more functional and pathway information on the essential genes and provides a new way to investigate related problems.
Journal ArticleDOI
Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases
Jialiang Yang,Tao Huang,Francesca Petralia,Quan Long,Bin Zhang,Carmen Argmann,Yong Zhao,Charles V. Mobbs,Eric E. Schadt,Jun Zhu,Zhidong Tu,Kristin G. Ardlie,David S. DeLuca,Ayellet V. Segrè,Timothy J. Sullivan,Taylor Young,Ellen Gelfand,Casandra A. Trowbridge,Julian Maller,Taru Tukiainen,Monkol Lek,Lucas D. Ward,Lucas D. Ward,Pouya Kheradpour,Pouya Kheradpour,Benjamin Iriarte,Yan Meng,Cameron D. Palmer,Wendy Winckler,Joel N. Hirschhorn,Manolis Kellis,Manolis Kellis,Daniel G. MacArthur,Gad Getz,Andrey A. Shablin,Gen Li,Yi-Hui Zhou,Andrew B. Nobel,Ivan Rusyn,Ivan Rusyn,Fred A. Wright,Tuuli Lappalainen,Pedro G. Ferreira,Pedro G. Ferreira,Halit Ongen,Halit Ongen,Manuel A. Rivas,Alexis Battle,Alexis Battle,Sara Mostafavi,Jean Monlong,Jean Monlong,Michael Sammeth,Marta Melé,Marta Melé,Ferran Reverter,Jakob Goldman,Daphne Koller,Roderic Guigó,Mark I. McCarthy,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Eric R. Gamazon,Anuar Konkashbaev,Dan L. Nicolae,Nancy J. Cox,Timothée Flutre,Xiaoquan Wen,Matthew Stephens,Jonathan K. Pritchard,Jonathan K. Pritchard,Jonathan K. Pritchard,Luan Lin,Jun Liu,Amanda M. V. Brown,Bernadette Mestichelli,Denee Tidwell,Edmund Lo,Mike Salvatore,Saboor Shad,Jeffrey A. Thomas,John T. Lonsdale,Christopher Choi,Ellen Karasik,Kimberly Ramsey,Michael T. Moser,Barbara A. Foster,Bryan Gillard,John Syron,Johnelle Fleming,Harold Magazine,Rick Hasz,Gary Walters,Jason Bridge,Mark Miklos,Susan L. Sullivan,Laura Barker,Heather M. Traino,Magboeba Mosavel,Laura A. Siminoff,Laura A. Siminoff,Dana R. Valley,Daniel C. Rohrer,Scott Jewel,Philip A. Branton,Leslie H. Sobin,Liqun Qi,Pushpa Hariharan,Shenpei Wu,David Tabor,Charles Shive,Anna M. Smith,Stephen A. Buia,Anita H. Undale,Karna Robinson,Nancy Roche,Kimberly M. Valentino,Angela Britton,Robin Burges,Debra Bradbury,Kenneth W. Hambright,John Seleski,Greg E. Korzeniewski,Kenyon Erickson,Yvonne Marcus,Jorge Tejada,Mehran Taherian,Chunrong Lu,Barnaby E. Robles,Margaret J. Basile,Deborah C. Mash,Simona Volpi,Jeff Struewing,Gary F. Temple,Joy T. Boyer,Deborah Colantuoni,Roger Little,Susan E. Koester,Latarsha J. Carithers,Helen M. Moore,Ping Guan,Carolyn C. Compton,Sherilyn Sawyer,Joanne P. Demchok,Jimmie B. Vaught,Chana A. Rabiner,Nicole C. Lockhart +146 more
TL;DR: In this article, the aging gene expression signatures are very tissue specific and enrichment for some well-known aging components such as mitochondria biology is observed in many tissues, and different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on principal component analysis.