Thomas Abeel

TL;DR: The first whole genome-based analysis of the emergence of drug resistance among clinical isolates of M. tuberculosis shows that the ancestral precursor of the LAM4 XDR outbreak strain in Tugela Ferry gained mutations to first-line drugs at the beginning of the antibiotic era.

TL;DR: Molecular diagnostics that include markers for rifampicin resistance alone will be insufficient to identify pre-MDR strains, and incorporation of knowledge of polymorphisms that occur before the emergence of multidrug resistance, particularly katG p.Ser315Thr, into molecular diagnostics should enable targeted treatment of patients with pre-mDR-TB to prevent further development of MDR- TB.

TL;DR: Already available approaches to construct and use pan-genomes are examined, the potential benefits of future technologies and methodologies are discussed, and open challenges from the vantage point of the above-mentioned biological disciplines are reviewed.

TL;DR: A novel approach for predicting promoters in whole-genome sequences by using large-scale structural properties of DNA that requires no training, is applicable to many eukaryotic genomes, and performs extremely well in comparison with the best available promoter prediction programs.

TL;DR: The data indicate that AN3 associates with chromatin remodelers to regulate transcription, and place the SWI/SNF-AN3 module as a major player at the transition from cell proliferation to cell differentiation in a developing leaf.