Proceedings from the 2nd European Clinical Consensus Conference for device-based therapies for hypertension: state of the art and considerations for the future.
Felix Mahfoud,Felix Mahfoud,Roland E. Schmieder,Michel Azizi,Michel Azizi,Atul Pathak,Horst Sievert,Costas Tsioufis,Thomas Zeller,Stefan Bertog,Peter J. Blankestijn,Michael Böhm,Michel Burnier,Gilles Chatellier,Isabelle Durand Zaleski,Sebastian Ewen,Guido Grassi,Michael Joner,Sverre E. Kjeldsen,Melvin D. Lobo,Chaim Lotan,Thomas F. Lüscher,Gianfranco Parati,Patrick Rossignol,Luis M. Ruilope,Faisal Sharif,Evert van Leeuwen,Massimo Volpe,Stephan Windecker,Adam Witkowski,William Wijns +30 more
TLDR
The European Expert Group pointed out the major unmet need of standardization of measurements, trial design and procedural performance, and the need for high-quality, collaborative research and openness to new methods for recruitment, patient selection, and assessment of outcomes will be able to establish incontrovertibly whether device therapies for hypertension are effective.Abstract:
The interest in RDN for hypertension has fluctuated recently, with a flurry of initial enthusiasm followed by sudden loss of interest by researchers and device manufacturers, with an almost as sudden resurgence in clinical trials activity and device innovation more recently. There is widespread consensus that this therapeutic strategy can be effective, at least for some of the technologies available. Major uncertainties remain as to the clinical role of RDN, and whether any of the emerging technologies such as AV-anastomosis formation, carotid body ablation, carotid bulb expansion, or baroreflex stimulation will have a future as effective treatment options in patients with hypertension. In our first consensus report in 2015, the European Expert Group pointed to the major unmet need of standardization of measurements, trial design and procedural performance.6 With the large number of different technologies currently in the pipeline, this need has even increased. Only through high-quality, collaborative research and openness to new methods for recruitment, patient selection, and assessment of outcomes will it be possible to establish incontrovertibly whether device therapies for hypertension are effective and what are preferred patient populations. Once the proof of concept is established, further studies with a design relevant to clinical reality will be needed to establish the place of new devices in the treatment armoury. The clinical and research community has a large responsibility to prove or disprove the value of new therapies, in order to ensure that antihypertensive devices provide future patients with the greatest benefit and the smallest risk. copy; The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology.read more
Citations
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2018 ESC/ESH Guidelines for the management of arterial hypertension.
B. Williams,G. Mancia,Wilko Spiering,Agabiti Rosei E,M. Azizi,Michel Burnier,Denis Clement,A. Coca,de Simone G,A Dominiczak,T. Kahan,Felix Mahfoud,Josep Redon,L.M. Ruilope,Alberto Zanchetti,Mary Kerins,S.E. Kjeldsen,Reinhold Kreutz,S. Laurent,Lip Gyh.,Richard J McManus,Krzysztof Narkiewicz,Frank Ruschitzka,R.E. Schmieder,Evgeny Shlyakhto,Constantinos Tsioufis,Aboyans,Ileana Desormais +27 more
Journal ArticleDOI
2018 ESC/ESH Guidelines for the management of arterial hypertension : The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension
Bryan Williams,Giuseppe Mancia,Wilko Spiering,Enrico Agabiti Rosei,Michel Azizi,Michel Burnier,Denis Clement,Antonio Coca,Giovanni de Simone,Anna F. Dominiczak,Thomas Kahan,Felix Mahfoud,Josep Redon,Luis M. Ruilope,Alberto Zanchetti,Mary Kerins,Sverre E. Kjeldsen,Reinhold Kreutz,Stéphane Laurent,Gregory Y.H. Lip,Richard J McManus,Krzysztof Narkiewicz,Frank Ruschitzka,Roland E. Schmieder,Evgeny Shlyakhto,Costas Tsioufis,Victor Aboyans,Ileana Desormais +27 more
TL;DR: De Backer et al. as mentioned in this paper developed the ESC Guidelines for the ESC Review Co-ordinator, which are used for the evaluation of the ESC review process and the review process.
Journal ArticleDOI
[2018 ESC/ESH Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH)].
Bryan Williams,Giuseppe Mancia,Wilko Spiering,Enrico Agabiti Rosei,Michel Azizi,Michel Burnier,Denis Clement,Antonio Coca,Giovanni de Simone,Anna F. Dominiczak,Thomas Kahan,Felix Mahfoud,Josep Redon,Luis M. Ruilope,Alberto Zanchetti,Mary Kerins,Sverre E. Kjeldsen,Reinhold Kreutz,Stéphane Laurent,Gregory Y.H. Lip,Richard J McManus,Krzysztof Narkiewicz,Frank Ruschitzka,Roland E. Schmieder,Evgeny Shlyakhto,Costas Tsioufis,Victor Aboyans,Ileana Desormais +27 more
TL;DR: Authors/Task Force Members: Bryan Williams* (ESC Chairperson), Giuseppe Mancia* (ESH Chairperson) (Italy), Wilko Spiering (The Netherlands), Enrico Agabiti Rosei ( Italy), Michel Azizi (France), Michel Burnier (Switzerland), Denis L. Kjeldsen (Norway), Reinhold Kreutz (Germany), Stephane Laurent (France)
Journal ArticleDOI
Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial
Raymond R. Townsend,Felix Mahfoud,Felix Mahfoud,David E. Kandzari,Kazuomi Kario,Stuart J. Pocock,Michael A. Weber,Sebastian Ewen,Konstantinos Tsioufis,Dimitrios Tousoulis,Andrew S.P. Sharp,A. Watkinson,Roland E. Schmieder,Axel Schmid,James W. Choi,Cara East,Anthony Walton,Ingrid Hopper,Debbie L. Cohen,Robert L. Wilensky,David P. Lee,Adrian Ma,Chandan Devireddy,Janice P. Lea,Philipp Lurz,Karl Fengler,Justin E. Davies,Neil Chapman,Sidney Cohen,Vanessa DeBruin,Martin Fahy,Denise E Jones,Martin T. Rothman,Michael Böhm,Jiro Aoki,Bryan Batson,George Dangas,Shukri David,David E. Kandzari,Manesh R. Patel,Kiritkumar Patel,Jasvindar Singh,Thomas Weber,Joachim Weil,Thomas Zeller,Khaled M. Ziada,Kengo Tanabe,Robert Wilkins,Johanna Contreras,Susan Steigerwalt,Denise Reedus,Satoshi Hoshide,Laura P. Svetkey,Anjani Rao,Angela L. Brown,Markus Suppan,Tolga Agdirlioglu,Elias Noory,Craig Chasen +58 more
TL;DR: Results from SPYRAL HTN-OFF MED provide biological proof of principle for the blood-pressure-lowering efficacy of renal denervation in the absence of antihypertensive medications.
Journal ArticleDOI
Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial
David E. Kandzari,Michael Böhm,Felix Mahfoud,Felix Mahfoud,Raymond R. Townsend,Michael A. Weber,Stuart J. Pocock,Konstantinos Tsioufis,Dimitrios Tousoulis,James W. Choi,Cara East,Sandeep Brar,Sidney Cohen,Martin Fahy,Garrett Pilcher,Kazuomi Kario,Jiro Aoki,Bryan Batson,Debbie L. Cohen,George Dangas,Shukri David,Justin E. Davies,Chandan Devireddy,David E. Kandzari,David P. Lee,Philipp Lurz,Vasilios Papademetriou,Manesh R. Patel,Kiritkumar Patel,Roland E. Schmieder,Andrew S.P. Sharp,Jasvindar Singh,Antony Walton,Thomas Weber,Joachim Weil,Thomas Zeller,Khaled M. Ziada,Kengo Tanabe,Robert Wilkins,Robert L. Wilensky,Johanna Contreras,Susan Steigerwalt,Neil Chapman,Janice P. Lea,Denise Reedus,Satoshi Hoshide,Adrian Ma,Karl Fengler,Ping Li,Laura P. Svetkey,Anjani Rao,Axel Schmid,A. Watkinson,Angela L. Brown,Ingrid Hopper,Markus Suppan,Tolga Agdirlioglu,Elias Noory,Craig Chasen +58 more
TL;DR: Renal denervation in the main renal arteries and branches significantly reduced blood pressure compared with sham control with no major safety events.
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A Randomized Trial of Intensive versus Standard Blood-Pressure Control
Jackson T. Wright,Jeff D. Williamson,Paul K. Whelton,Joni K. Snyder,Kaycee M. Sink,Michael V. Rocco,David M. Reboussin,Mahboob Rahman,Mahboob Rahman,Suzanne Oparil,Cora E. Lewis,Paul L. Kimmel,Karen C. Johnson,David C. Goff,Lawrence J. Fine,Jeffrey A. Cutler,William C. Cushman,Alfred K. Cheung,Walter T. Ambrosius +18 more
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TL;DR: In this article, a systematic review and meta-analysis of large-scale blood pressure lowering trials, published between Jan 1, 1966, and July 7, 2015, was performed.
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