T
Tokiko Watanabe
Researcher at University of Tokyo
Publications - 91
Citations - 10611
Tokiko Watanabe is an academic researcher from University of Tokyo. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 42, co-authored 86 publications receiving 9344 citations. Previous affiliations of Tokiko Watanabe include Osaka University & University of Wisconsin-Madison.
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Journal ArticleDOI
Generation of influenza A viruses entirely from cloned cDNAs
Gabriele Neumann,Tokiko Watanabe,Hiroshi Ito,Shinji Watanabe,Hideo Goto,Peng Gao,Mark A. Hughes,Daniel R. Perez,Ruben O. Donis,Erich Hoffmann,Gerd Hobom,Yoshihiro Kawaoka +11 more
TL;DR: A new reverse-genetics system that allows one to efficiently generate influenza A viruses entirely from cloned cDNAs is described, which should be useful in viral mutagenesis studies and in the production of vaccines and gene therapy vectors.
Journal ArticleDOI
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
Masaki Imai,Tokiko Watanabe,Masato Hatta,Subash C. Das,Makoto Ozawa,Makoto Ozawa,Kyoko Shinya,Gongxun Zhong,Anthony Hanson,Hiroaki Katsura,Shinji Watanabe,Chengjun Li,Eiryo Kawakami,Shinya Yamada,Maki Kiso,Yasuo Suzuki,Eileen A. Maher,Gabriele Neumann,Yoshihiro Kawaoka +18 more
TL;DR: Results indicate that H5 HA can convert to an HA that supports efficient viral transmission in mammals, and will help individuals conducting surveillance in regions with circulating H5N1 viruses to recognize key residues that predict the pandemic potential of isolate, which will inform the development, production and distribution of effective countermeasures.
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In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Yasushi Itoh,Kyoko Shinya,Maki Kiso,Tokiko Watanabe,Yoshihiro Sakoda,Masato Hatta,Yukiko Muramoto,Daisuke Tamura,Yuko Sakai-Tagawa,Takeshi Noda,Saori Sakabe,Masaki Imai,Yasuko Hatta,Shinji Watanabe,Chengjun Li,Shinya Yamada,Ken Fujii,Shin Murakami,Hirotaka Imai,Satoshi Kakugawa,Mutsumi Ito,Ryo Takano,Kiyoko Iwatsuki-Horimoto,Masayuki Shimojima,Taisuke Horimoto,Hideo Goto,Kei Takahashi,Akiko Makino,Hirohito Ishigaki,Misako Nakayama,Masatoshi Okamatsu,Kazuo Takahashi,David Warshauer,Peter A. Shult,Reiko Saito,Hiroshi Suzuki,Yousuke Furuta,Makoto Yamashita,Keiko Mitamura,Kunio Nakano,Morio Nakamura,Rebecca A. Brockman-Schneider,Hiroshi Mitamura,Masahiko Yamazaki,Norio Sugaya,M. Suresh,Makoto Ozawa,Makoto Ozawa,Gabriele Neumann,James E. Gern,Hiroshi Kida,Kazumasa Ogasawara,Yoshihiro Kawaoka +52 more
TL;DR: It is shown that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.
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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development.
Masaki Imai,Kiyoko Iwatsuki-Horimoto,Masato Hatta,Samantha Loeber,Peter Halfmann,Noriko Nakajima,Tokiko Watanabe,Michiko Ujie,Kenta Takahashi,Mutsumi Ito,Shinya Yamada,Shufang Fan,Shiho Chiba,Makoto Kuroda,Lizheng Guan,Kosuke Takada,Tammy Armbrust,Aaron Balogh,Yuri Furusawa,Moe Okuda,Hiroshi Ueki,Atsuhiro Yasuhara,Yuko Sakai-Tagawa,Tiago J. S. Lopes,Tiago J. S. Lopes,Maki Kiso,Seiya Yamayoshi,Noriko Kinoshita,Norio Ohmagari,Shin-ichiro Hattori,Makoto Takeda,Hiroaki Mitsuya,Florian Krammer,Tadaki Suzuki,Yoshihiro Kawaoka,Yoshihiro Kawaoka +35 more
TL;DR: It is found that SARS-CoV-2 isolates replicate efficiently in the lungs of Syrian hamsters and cause severe pathological lesions in the lung of these animals similar to commonly reported imaging features of COVID-19 patients with pneumonia.
Journal ArticleDOI
Drosophila RNAi screen identifies host genes important for influenza virus replication
Linhui Hao,Akira Sakurai,Tokiko Watanabe,Ericka M. Sorensen,Chairul A. Nidom,Michael A. Newton,Paul G. Ahlquist,Yoshihiro Kawaoka +7 more
TL;DR: The feasibility of using genome-wide RNAi screens in Drosophila to identify previously unrecognized host proteins that are required for influenza virus replication is demonstrated and could accelerate the development of new classes of antiviral drugs for chemoprophylaxis and treatment.