T
Tom den Heijer
Researcher at Erasmus University Rotterdam
Publications - 46
Citations - 6232
Tom den Heijer is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Dementia & Population. The author has an hindex of 24, co-authored 38 publications receiving 5610 citations.
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Journal ArticleDOI
Silent brain infarcts and the risk of dementia and cognitive decline
Sarah E. Vermeer,Niels D. Prins,Tom den Heijer,Albert Hofman,Peter J. Koudstaal,Monique M.B. Breteler +5 more
TL;DR: Elderly people with silent brain infarcts have an increased risk of dementia and a steeper decline in cognitive function than those without such lesions.
Journal ArticleDOI
Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study.
Annemieke Ruitenberg,Tom den Heijer,S. L. M. Bakker,John C. van Swieten,Peter J. Koudstaal,Albert Hofman,Monique M.B. Breteler +6 more
TL;DR: The relation of CBF velocity as measured with transcranial Doppler with dementia and markers of incipient dementia in 1,730 participants of the Rotterdam Study suggests cerebral hypoperfusion precedes and possibly contributes to onset of clinical dementia.
Journal ArticleDOI
Cerebral small-vessel disease and decline in information processing speed, executive function and memory
Niels D. Prins,Ewoud J. van Dijk,Tom den Heijer,Sarah E. Vermeer,Jellemer Jolles,Peter J. Koudstaal,Albert Hofman,Monique M.B. Breteler +7 more
TL;DR: The results suggest that in older people cerebral small-vessel disease may contribute to cognitive decline by affecting information processing speed and executive function.
Journal ArticleDOI
Cerebral white matter lesions and the risk of dementia.
Niels D. Prins,Ewoud J. van Dijk,Tom den Heijer,Sarah E. Vermeer,Peter J. Koudstaal,Matthijs Oudkerk,Albert Hofman,Monique M.B. Breteler +7 more
TL;DR: Higher severity of periventricular WML increased the risk of dementia, whereas the association between subcortical WML and dementia was less prominent, and this increased risk was independent of other risk factors for dementia and partlyindependent of other structural brain changes on magnetic resonance imaging.
Journal ArticleDOI
Common variants at 12q14 and 12q24 are associated with hippocampal volume
Joshua C. Bis,Charles DeCarli,Albert V. Smith,Fedde van der Lijn,Fabrice Crivello,Fabrice Crivello,Myriam Fornage,Stephanie Debette,Stephanie Debette,Joshua M. Shulman,Joshua M. Shulman,Helena Schmidt,Velandai Srikanth,Velandai Srikanth,Maaike Schuur,Lei Yu,Seung Hoan Choi,Sigurdur Sigurdsson,Benjamin F.J. Verhaaren,Anita L. DeStefano,Jean-Charles Lambert,Clifford R. Jack,Maksim Struchalin,Jim Stankovich,Carla A. Ibrahim-Verbaas,Debra A. Fleischman,Alex P. Zijdenbos,Tom den Heijer,Bernard Mazoyer,Bernard Mazoyer,Laura H. Coker,Christian Enzinger,Patrick Danoy,Najaf Amin,Konstantinos Arfanakis,Konstantinos Arfanakis,Mark A. van Buchem,Renée F A G de Bruijn,Alexa S. Beiser,Carole Dufouil,Juebin Huang,Margherita Cavalieri,Russell Thomson,Wiro J. Niessen,Wiro J. Niessen,Lori B. Chibnik,Lori B. Chibnik,Gauti Kjartan Gislason,Albert Hofman,Aleksandra Pikula,Philippe Amouyel,Kevin B. Freeman,Thanh G. Phan,Ben A. Oostra,Jason L. Stein,Sarah E. Medland,Sarah E. Medland,Alejandro Arias Vasquez,Derrek P. Hibar,Margaret J. Wright,Barbara Franke,Nicholas G. Martin,Paul M. Thompson,Mike A. Nalls,André G. Uitterlinden,Rhoda Au,Alexis Elbaz,Richard Beare,Richard Beare,John C. van Swieten,Oscar L. Lopez,Tamara B. Harris,Vincent Chouraki,Monique M.B. Breteler,Monique M.B. Breteler,Monique M.B. Breteler,Philip L. De Jager,Philip L. De Jager,James T. Becker,Meike W. Vernooij,David S. Knopman,Franz Fazekas,Philip A. Wolf,Aad van der Lugt,Vilmundur Gudnason,William T. Longstreth,Matthew A. Brown,David A. Bennett,Cornelia M. van Duijn,Cornelia M. van Duijn,Thomas H. Mosley,Reinhold Schmidt,Christophe Tzourio,Christophe Tzourio,Lenore J. Launer,M. Arfan Ikram,Sudha Seshadri +96 more
TL;DR: In this article, a genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10(-7).