S
Sarah E. Medland
Researcher at QIMR Berghofer Medical Research Institute
Publications - 18
Citations - 861
Sarah E. Medland is an academic researcher from QIMR Berghofer Medical Research Institute. The author has contributed to research in topics: Genome-wide association study & Genetic association. The author has an hindex of 8, co-authored 18 publications receiving 582 citations. Previous affiliations of Sarah E. Medland include University of Queensland & Broad Institute.
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Journal ArticleDOI
Common variants at 12q14 and 12q24 are associated with hippocampal volume
Joshua C. Bis,Charles DeCarli,Albert V. Smith,Fedde van der Lijn,Fabrice Crivello,Fabrice Crivello,Myriam Fornage,Stephanie Debette,Stephanie Debette,Joshua M. Shulman,Joshua M. Shulman,Helena Schmidt,Velandai Srikanth,Velandai Srikanth,Maaike Schuur,Lei Yu,Seung Hoan Choi,Sigurdur Sigurdsson,Benjamin F.J. Verhaaren,Anita L. DeStefano,Jean-Charles Lambert,Clifford R. Jack,Maksim Struchalin,Jim Stankovich,Carla A. Ibrahim-Verbaas,Debra A. Fleischman,Alex P. Zijdenbos,Tom den Heijer,Bernard Mazoyer,Bernard Mazoyer,Laura H. Coker,Christian Enzinger,Patrick Danoy,Najaf Amin,Konstantinos Arfanakis,Konstantinos Arfanakis,Mark A. van Buchem,Renée F A G de Bruijn,Alexa S. Beiser,Carole Dufouil,Juebin Huang,Margherita Cavalieri,Russell Thomson,Wiro J. Niessen,Wiro J. Niessen,Lori B. Chibnik,Lori B. Chibnik,Gauti Kjartan Gislason,Albert Hofman,Aleksandra Pikula,Philippe Amouyel,Kevin B. Freeman,Thanh G. Phan,Ben A. Oostra,Jason L. Stein,Sarah E. Medland,Sarah E. Medland,Alejandro Arias Vasquez,Derrek P. Hibar,Margaret J. Wright,Barbara Franke,Nicholas G. Martin,Paul M. Thompson,Mike A. Nalls,André G. Uitterlinden,Rhoda Au,Alexis Elbaz,Richard Beare,Richard Beare,John C. van Swieten,Oscar L. Lopez,Tamara B. Harris,Vincent Chouraki,Monique M.B. Breteler,Monique M.B. Breteler,Monique M.B. Breteler,Philip L. De Jager,Philip L. De Jager,James T. Becker,Meike W. Vernooij,David S. Knopman,Franz Fazekas,Philip A. Wolf,Aad van der Lugt,Vilmundur Gudnason,William T. Longstreth,Matthew A. Brown,David A. Bennett,Cornelia M. van Duijn,Cornelia M. van Duijn,Thomas H. Mosley,Reinhold Schmidt,Christophe Tzourio,Christophe Tzourio,Lenore J. Launer,M. Arfan Ikram,Sudha Seshadri +96 more
TL;DR: In this article, a genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10(-7).
Journal ArticleDOI
Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
Jessica Tyrrell,Jessica Tyrrell,Rebecca C Richmond,Rebecca C Richmond,Tom Palmer,Tom Palmer,Bjarke Feenstra,Janani Rangarajan,Sarah Metrustry,Alana Cavadino,Alana Cavadino,Lavinia Paternoster,Loren L. Armstrong,N. Maneka G. De Silva,Andrew R. Wood,Momoko Horikoshi,Momoko Horikoshi,Frank Geller,Ronny Myhre,Jonathan P. Bradfield,Eskil Kreiner-Møller,Ville Huikari,Jodie N. Painter,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Catherine Allard,Catherine Allard,Diane J. Berry,Luigi Bouchard,Luigi Bouchard,Shikta Das,David M. Evans,David M. Evans,Hakon Hakonarson,Hakon Hakonarson,M. Geoffrey Hayes,Jani Heikkinen,Albert Hofman,Albert Hofman,Bridget A. Knight,Penelope A. Lind,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,George McMahon,Sarah E. Medland,Mads Melbye,Mads Melbye,Andrew P. Morris,Andrew P. Morris,Michael Nodzenski,Christoph Reichetzeder,Christoph Reichetzeder,Susan M. Ring,Sylvain Sebert,Sylvain Sebert,Verena Sengpiel,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Gonneke Willemsen,Gonneke Willemsen,Eco J. C. de Geus,Eco J. C. de Geus,Nicholas G. Martin,Tim D. Spector,Christine Power,Marjo-Riitta Järvelin,Hans Bisgaard,Struan F.A. Grant,Struan F.A. Grant,Ellen A. Nohr,Vincent W. V. Jaddoe,Bo Jacobsson,Bo Jacobsson,Jeff Murray,Berthold Hocher,Berthold Hocher,Andrew T. Hattersley,Denise M. Scholtens,George Davey Smith,Marie-France Hivert,Marie-France Hivert,Janine F. Felix,Elina Hyppönen,Elina Hyppönen,William L. Lowe,Timothy M. Frayling,Debbie A Lawlor,Rachel M. Freathy,Rachel M. Freathy +89 more
TL;DR: For BMI and fasting glucose, genetic associations were consistent with the observational associations, but for systolic blood pressure, the genetic and observational associations were in opposite directions.
Journal ArticleDOI
Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
Rui Li,Felix F. Brockschmidt,Amy K. Kiefer,Hreinn Stefansson,Dale R. Nyholt,Kijoung Song,Sita H. Vermeulen,Stavroula Kanoni,Daniel Glass,Sarah E. Medland,Maria Dimitriou,Dawn Waterworth,Joyce Y. Tung,Frank Geller,Stefanie Heilmann,Axel M. Hillmer,Veronique Bataille,Sibylle Eigelshoven,Sandra Hanneken,Susanne Moebus,Christine Herold,Martin den Heijer,Grant W. Montgomery,Panos Deloukas,Nicholas Eriksson,Andrew C. Heath,Tim Becker,Tim Becker,Patrick Sulem,Massimo Mangino,Peter Vollenweider,Tim D. Spector,George Dedoussis,Nicholas G. Martin,Lambertus A. Kiemeney,Vincent Mooser,Kari Stefansson,David A. Hinds,Markus M. Nöthen,Markus M. Nöthen,J. Brent Richards,J. Brent Richards +41 more
TL;DR: In this article, a large-scale meta-analysis of seven genome-wide association studies for early-onset AGA in 12,806 individuals of European ancestry was conducted and the association between early-onset AGA, Parkinson's disease, and decreased fertility was found.
Posted ContentDOI
Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors
Niamh Mullins,Jooeun Kang,Adrian I. Campos,Adrian I. Campos,Jonathan R. I. Coleman,Jonathan R. I. Coleman,Alexis C. Edwards,Hanga Galfalvy,Daniel F. Levey,Daniel F. Levey,Adriana Lori,Andrey A. Shabalin,Anna Starnawska,Mei-Hsin Su,Hunna J. Watson,Hunna J. Watson,Hunna J. Watson,Mark Adams,Swapnil Awasthi,Michael J. Gandal,Jonathan D. Hafferty,Akitoyo Hishimoto,Minsoo Kim,Satoshi Okazaki,Ikuo Otsuka,Ikuo Otsuka,Stephan Ripke,Stephan Ripke,Stephan Ripke,Erin B. Ware,Andrew W. Bergen,Wade H. Berrettini,Martin Bohus,Harry Brandt,Xiao Chang,Wei J. Chen,Wei J. Chen,Hsi-Chung Chen,Steven Crawford,Scott J. Crow,Emily DiBlasi,Philibert Duriez,Fernando Fernández-Aranda,Manfred M. Fichter,Steven Gallinger,Stephen J. Glatt,Philip Gorwood,Yiran Guo,Hakon Hakonarson,Hakon Hakonarson,Katherine A. Halmi,Hai-Gwo Hwu,Sonia Jain,Stéphane Jamain,Susana Jiménez-Murcia,Craig Johnson,Allan S. Kaplan,Allan S. Kaplan,Walter H. Kaye,Pamela K. Keel,James L. Kennedy,James L. Kennedy,Kelly L. Klump,Robert D. Levitan,Robert D. Levitan,Dong Li,Shih-Cheng Liao,Klaus Lieb,Lisa Lilenfeld,Chih-Min Liu,Pierre J. Magistretti,Pierre J. Magistretti,Christian R. Marshall,James E. Mitchell,Eric T. Monson,Richard M. Myers,Dalila Pinto,Abigail Powers,Nicolas Ramoz,Stefan Roepke,Alessandro Rotondo,Vsevolod Rozanov,Stephen W. Scherer,Christian Schmahl,M. Sokolowski,Michael Strober,Michael Strober,Laura M. Thornton,Janet Treasure,Janet Treasure,Ming T. Tsuang,Maria La Via,Stephanie H. Witt,D. Blake Woodside,Zeynep Yilmaz,Zeynep Yilmaz,Lea Zillich,Rolf Adolfsson,Ingrid Agartz,Ingrid Agartz,Tracy Air,Martin Alda,Lars Alfredsson,Ole A. Andreassen,Ole A. Andreassen,Adebayo Anjorin,Vivek Appadurai,Vivek Appadurai,María Soler Artigas,Sandra Van der Auwera,M. Helena Azevedo,Nicholas Bass,Claiton Hd Bau,Bernhard T. Baune,Bernhard T. Baune,Frank Bellivier,Klaus Berger,Joanna M. Biernacka,Tim B. Bigdeli,Tim B. Bigdeli,Elisabeth B. Binder,Elisabeth B. Binder,Michael Boehnke,Marco P. Boks,Rosa Bosch,Rosa Bosch,David L. Braff,Richard A. Bryant,Monika Budde,Enda M. Byrne,Wiepke Cahn,Miguel Casas,Enrique Castelao,Jorge A. Cervilla,Boris Chaumette,Boris Chaumette,Sven Cichon,Aiden Corvin,Nicholas John Craddock,David Craig,Franziska Degenhardt,Srdjan Djurovic,Srdjan Djurovic,Howard J. Edenberg,Ayman H. Fanous,Ayman H. Fanous,Jerome C. Foo,Andreas J. Forstner,Andreas J. Forstner,Andreas J. Forstner,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Justine M. Gatt,Pablo V. Gejman,Pablo V. Gejman,Ina Giegling,Ina Giegling,Hans J. Grabe,Melissa J. Green,Melissa J. Green,Eugenio H. Grevet,Maria Grigoroiu-Serbanescu,Blanca Gutiérrez,Jose Guzman-Parra,Steven P. Hamilton,Marian L. Hamshere,Annette M. Hartmann,Joanna Hauser,Stefanie Heilmann-Heimbach,Per Hoffmann,Per Hoffmann,Per Hoffmann,Marcus Ising,Ian Jones,Lisa Jones,Lina Jonsson,René S. Kahn,John R. Kelsoe,Kenneth S. Kendler,Stefan Kloiber,Stefan Kloiber,Stefan Kloiber,Karestan C. Koenen,Karestan C. Koenen,Manolis Kogevinas,Bettina Konte,Marie-Odile Krebs,Marie-Odile Krebs,Mikael Landén,Mikael Landén,Jacob Lawrence,Marion Leboyer,Marion Leboyer,Phil Lee,Phil Lee,Douglas F. Levinson,Calwing Liao,Calwing Liao,Jolanta Lissowska,Susanne Lucae,Fermín Mayoral,Susan L. McElroy,Patrick J. McGrath,Peter McGuffin,Andrew McQuillin,Sarah E. Medland,Divya Mehta,Divya Mehta,Ingrid Melle,Ingrid Melle,Yuri Milaneschi,Philip B. Mitchell,Esther Molina,Gunnar Morken,Preben Bo Mortensen,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Caroline M. Nievergelt,Vishwajit L. Nimgaonkar,Markus M. Nöthen,Michael Conlon O'Donovan,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Carlos N. Pato,Michele T. Pato,Brenda W.J.H. Penninx,Jonathan Pimm,Giorgio Pistis,James B. Potash,Robert A Power,Robert A Power,Martin Preisig,Digby Quested,Josep Antoni Ramos-Quiroga,Andreas Reif,Marta Ribasés,Vanesa Richarte,Vanesa Richarte,Marcella Rietschel,Margarita Rivera,Margarita Rivera,Andrea L. Roberts,Gloria Roberts,Guy A. Rouleau,Guy A. Rouleau,Diego L. Rovaris,Dan Rujescu,Cristina Sánchez-Mora,Alan R. Sanders,Alan R. Sanders,Peter R. Schofield,Peter R. Schofield,Thomas G. Schulze,Laura J. Scott,Alessandro Serretti,Jianxin Shi,Stanley I. Shyn,Lea Sirignano,Pamela Sklar,Olav B. Smeland,Olav B. Smeland,Jordan W. Smoller,Jordan W. Smoller,Edmund J.S. Sonuga-Barke,Gianfranco Spalletta,John Strauss,John Strauss,Beata Świątkowska,Maciej Trzaskowski,Gustavo Turecki,Laura Vilar-Ribó,John B. Vincent,Henry Völzke,James T.R. Walters,Cynthia Shannon Weickert,Thomas W. Weickert,Myrna M. Weissman,Leanne M. Williams,Naomi R. Wray,Clement C. Zai,Esben Agerbo,Esben Agerbo,Anders D. Børglum,Gerome Breen,Gerome Breen,Annette Erlangsen,Tõnu Esko,Tõnu Esko,Joel Gelernter,Joel Gelernter,David M. Hougaard,David M. Hougaard,Ronald C. Kessler,Henry R. Kranzler,Qingqin S. Li,Nicholas G. Martin,Andrew M. McIntosh,Sarah E. Medland,Ole Mors,Ole Mors,Merete Nordentoft,Merete Nordentoft,Catherine M. Olsen,David J. Porteous,Robert J. Ursano,Danuta Wasserman,Thomas Werge,David C. Whiteman,Cynthia M. Bulik,Cynthia M. Bulik,Hilary Coon,Ditte Demontis,Anna R. Docherty,Anna R. Docherty,Po-Hsiu Kuo,Cathryn M. Lewis,J. John Mann,Miguel E. Rentería,Miguel E. Rentería,Daniel J. Smith,Eli A. Stahl,Eli A. Stahl,Murray B. Stein,Fabian Streit,Virginia L. Willour,Douglas M. Ruderfer +327 more
TL;DR: The results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest the existence of a shared genetic etiology between SA and known risk factors that is not mediated by psychiatric disorders.
Journal ArticleDOI
Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium.
Renato Polimanti,Roseann E. Peterson,Jue-Sheng Ong,Stuart MacGregor,Alexis C. Edwards,Toni-Kim Clarke,Josef Frank,Zachary Gerring,Nathan A. Gillespie,Penelope A. Lind,Hermine H. Maes,Nicholas G. Martin,Hamdi Mbarek,Sarah E. Medland,Fabian Streit,Arpana Agrawal,Howard J. Edenberg,Kenneth S. Kendler,Cathryn M. Lewis,Patrick F. Sullivan,Naomi R. Wray,Joel Gelernter,Eske M. Derks +22 more
TL;DR: In this paper, the authors leveraged genome-wide data from the Psychiatric Genomics Consortium (PGC) and UK Biobank to test for the presence of shared genetic mechanisms and causal relationships among major depression (MD), alcohol dependence (AD), and alcohol consumption (AC).