L
Lenore J. Launer
Researcher at Leiden University Medical Center
Publications - 37
Citations - 2271
Lenore J. Launer is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Dementia & Population. The author has an hindex of 19, co-authored 37 publications receiving 1863 citations. Previous affiliations of Lenore J. Launer include University of Mississippi & University of Washington.
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Journal ArticleDOI
Novel genetic loci associated with hippocampal volume
Derrek P. Hibar,Hieab H.H. Adams,Neda Jahanshad,Ganesh Chauhan,Jason L. Stein,Jason L. Stein,Edith Hofer,Miguel E. Rentería,Joshua C. Bis,Alejandro Arias-Vasquez,M. Kamran Ikram,Sylvane Desrivières,Meike W. Vernooij,Lucija Abramovic,Saud Alhusaini,Saud Alhusaini,Najaf Amin,Micael Andersson,Konstantinos Arfanakis,Konstantinos Arfanakis,Benjamin S. Aribisala,Benjamin S. Aribisala,Nicola J. Armstrong,Nicola J. Armstrong,Lavinia Athanasiu,Tomas Axelsson,Ashley Beecham,Alexa S. Beiser,Alexa S. Beiser,Manon Bernard,Susan H. Blanton,Marc M. Bohlken,Marco P. Boks,Janita Bralten,Adam M. Brickman,Owen Carmichael,M. Mallar Chakravarty,M. Mallar Chakravarty,Qiang Chen,Christopher R.K. Ching,Christopher R.K. Ching,Vincent Chouraki,Vincent Chouraki,Vincent Chouraki,Gabriel Cuellar-Partida,Fabrice Crivello,Anouk den Braber,Nhat Trung Doan,Stefan Ehrlich,Stefan Ehrlich,Sudheer Giddaluru,Aaron Goldman,Rebecca F. Gottesman,Oliver Grimm,Michael Griswold,Tulio Guadalupe,Boris A. Gutman,Johanna Hass,Unn K. Haukvik,D. Hoehn,Avram J. Holmes,Avram J. Holmes,Martine Hoogman,Deborah Janowitz,Tianye Jia,Kjetil Nordbø Jørgensen,Nazanin Karbalai,Dalia Kasperaviciute,Dalia Kasperaviciute,Sungeun Kim,Marieke Klein,Bernd Kraemer,Phil Lee,Phil Lee,David C. Liewald,Lorna M. Lopez,Michelle Luciano,Christine Macare,Andre F. Marquand,Mar Matarin,Mar Matarin,Karen A. Mather,Manuel Mattheisen,Manuel Mattheisen,David R. McKay,Yuri Milaneschi,Susana Muñoz Maniega,Kwangsik Nho,Allison C. Nugent,Paul A. Nyquist,Loes M. Olde Loohuis,Jaap Oosterlaan,Martina Papmeyer,Martina Papmeyer,Lukas Pirpamer,Benno Pütz,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Jennifer S. Richards,Shannon L. Risacher,Roberto Roiz-Santiañez,Nanda Rommelse,Stefan Ropele,Emma J. Rose,Natalie A. Royle,Tatjana Rundek,Philipp G. Sämann,Arvin Saremi,Claudia L. Satizabal,Claudia L. Satizabal,Lianne Schmaal,Lianne Schmaal,Andrew J. Schork,Li Shen,Jean Shin,Elena Shumskaya,Albert V. Smith,Emma Sprooten,Emma Sprooten,Lachlan T. Strike,Lachlan T. Strike,Alexander Teumer,Diana Tordesillas-Gutiérrez,Roberto Toro,Daniah Trabzuni,Daniah Trabzuni,Stella Trompet,Dhananjay Vaidya,Jeroen van der Grond,Sven J. van der Lee,Dennis van der Meer,Marjolein M.J. van Donkelaar,Kristel R. van Eijk,Theo G.M. van Erp,Daan van Rooij,Daan van Rooij,Esther Walton,Esther Walton,Lars T. Westlye,Lars T. Westlye,Christopher D. Whelan,Christopher D. Whelan,Beverly G. Windham,Anderson M. Winkler,Anderson M. Winkler,Katharina Wittfeld,Katharina Wittfeld,Girma Woldehawariat,Christiane Wolf,Thomas Wolfers,Lisa R. Yanek,Jingyun Yang,Jingyun Yang,Alex P. Zijdenbos,Marcel P. Zwiers,Ingrid Agartz,Ingrid Agartz,Laura Almasy,Laura Almasy,Laura Almasy,D. Ames,D. Ames,Philippe Amouyel,Ole A. Andreassen,Sampath Arepalli,Amelia A. Assareh,Sandra Barral,Mark E. Bastin,Diane M. Becker,James T. Becker,David A. Bennett,David A. Bennett,John Blangero,Hans van Bokhoven,Dorret I. Boomsma,Henry Brodaty,Henry Brodaty,Rachel M. Brouwer,Han G. Brunner,Han G. Brunner,Randy L. Buckner,Randy L. Buckner,Jan K. Buitelaar,Kazima B. Bulayeva,Wiepke Cahn,Vince D. Calhoun,Dara M. Cannon,Dara M. Cannon,Gianpiero L. Cavalleri,Ching-Yu Cheng,Ching-Yu Cheng,Ching-Yu Cheng,Sven Cichon,Sven Cichon,Sven Cichon,M. R. Cookson,Aiden Corvin,Benedicto Crespo-Facorro,Joanne E. Curran,Michael Czisch,Anders M. Dale,Gareth E. Davies,Anton J. M. de Craen,Eco J. C. de Geus,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Greig I. de Zubicaray,Ian J. Deary,Stéphanie Debette,Stéphanie Debette,Stéphanie Debette,Charles C. DeCarli,Norman Delanty,Norman Delanty,Chantal Depondt,Anita L. DeStefano,Anita L. DeStefano,Allissa Dillman,Srdjan Djurovic,Srdjan Djurovic,G. Donohoe,G. Donohoe,Wayne C. Drevets,Wayne C. Drevets,Ravi Duggirala,Thomas D. Dyer,Christian Enzinger,Susanne Erk,Thomas Espeseth,Thomas Espeseth,Iryna O. Fedko,Guillén Fernández,Luigi Ferrucci,Simon E. Fisher,Simon E. Fisher,Debra A. Fleischman,Debra A. Fleischman,Ian Ford,Myriam Fornage,Tatiana Foroud,Tatiana Foroud,Peter T. Fox,Clyde Francks,Clyde Francks,Masaki Fukunaga,J. Raphael Gibbs,J. Raphael Gibbs,David C. Glahn,Randy L. Gollub,Harald H.H. Göring,Robert C. Green,Robert C. Green,Oliver Gruber,Vilmundur Gudnason,Sebastian Guelfi,Asta Håberg,Asta Håberg,Narelle K. Hansell,Narelle K. Hansell,John Hardy,Catharina A. Hartman,Ryota Hashimoto,Ryota Hashimoto,K Hegenscheid,Andreas Heinz,Stephanie Le Hellard,Dena G. Hernandez,Dena G. Hernandez,Dirk J. Heslenfeld,Beng-Choon Ho,Pieter J. Hoekstra,Wolfgang Hoffmann,Wolfgang Hoffmann,Albert Hofman,Florian Holsboer,Florian Holsboer,Georg Homuth,Norbert Hosten,Jouke-Jan Hottenga,Matthew J. Huentelman,Hilleke E. Hulshoff Pol,Masashi Ikeda,Clifford R. Jack,Mark Jenkinson,Robert Johnson,Erik G. Jönsson,Erik G. Jönsson,J. Wouter Jukema,René S. Kahn,Ryota Kanai,Ryota Kanai,Ryota Kanai,I. Kloszewska,David S. Knopman,Peter Kochunov,John B.J. Kwok,John B.J. Kwok,Stephen M. Lawrie,Herve Lemaitre,Xinmin Liu,Xinmin Liu,Dan L. Longo,Oscar L. Lopez,Simon Lovestone,Simon Lovestone,Oliver Martinez,Jean-Luc Martinot,Venkata S. Mattay,Venkata S. Mattay,C. McDonald,Andrew M. McIntosh,Francis J. McMahon,Katie L. McMahon,P. Mecocci,Ingrid Melle,Andreas Meyer-Lindenberg,Sebastian Mohnke,Grant W. Montgomery,D. Morris,Thomas H. Mosley,Thomas W. Mühleisen,Thomas W. Mühleisen,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Michael A. Nalls,Matthias Nauck,Matthias Nauck,Thomas E. Nichols,Wiro J. Niessen,Wiro J. Niessen,Markus M. Nöthen,Markus M. Nöthen,Lars Nyberg,Kazutaka Ohi,Rene L. Olvera,Roel A. Ophoff,Roel A. Ophoff,Massimo Pandolfo,Tomáš Paus,Tomáš Paus,Zdenka Pausova,Zdenka Pausova,Brenda W.J.H. Penninx,G. Bruce Pike,G. Bruce Pike,Steven G. Potkin,Bruce M. Psaty,Simone Reppermund,Simone Reppermund,Marcella Rietschel,Joshua L. Roffman,Nina Romanczuk-Seiferth,Jerome I. Rotter,Mina Ryten,Mina Ryten,Ralph L. Sacco,Ralph L. Sacco,Perminder S. Sachdev,Perminder S. Sachdev,Andrew J. Saykin,Andrew J. Saykin,Reinhold Schmidt,Helena Schmidt,Peter R. Schofield,Peter R. Schofield,Sigurdur Sigursson,Andrew Simmons,Andrew Simmons,Andrew Singleton,Sanjay M. Sisodiya,Colin Smith,Jordan W. Smoller,Jordan W. Smoller,Hilkka Soininen,Hilkka Soininen,Vidar M. Steen,David J. Stott,Jessika E. Sussmann,Anbupalam Thalamuthu,Arthur W. Toga,Bryan J. Traynor,Juan C. Troncoso,Magda Tsolaki,Christophe Tzourio,Christophe Tzourio,Andre G. Uitterlinden,Andre G. Uitterlinden,Maria del C. Valdés Hernández,Marcel Van Der Brug,Aad van der Lugt,Nic J.A. van der Wee,Neeltje E.M. van Haren,Dennis van 't Ent,Marie-José van Tol,Badri N. Vardarajan,Bruno Vellas,Dick J. Veltman,Henry Völzke,Henrik Walter,Joanna M. Wardlaw,Thomas H. Wassink,Michael E. Weale,Daniel R. Weinberger,Michael Weiner,Wei Wen,Wei Wen,Eric Westman,Tonya White,Tonya White,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Clinton B. Wright,Clinton B. Wright,Ronald H. Zielke,Alan B. Zonderman,Nicholas G. Martin,Cornelia M. van Duijn,Margaret J. Wright,Margaret J. Wright,William T. Longstreth,Gunter Schumann,Hans J. Grabe,Barbara Franke,Lenore J. Launer,Sarah E. Medland,Sudha Seshadri,Sudha Seshadri,Paul M. Thompson,M. Arfan Ikram,M. Arfan Ikram +432 more
TL;DR: It is shown that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=−0.155), and these findings suggest novel biological pathways through which human genetic variation influences hippocampus volume and risk for neuropsychiatric illness.
Homocysteine and Short-term Risk of Myocardial Infarction and Stroke in the Elderly
Michiel L. Bots,Lenore J. Launer,Jan Lindemans,A. W. Hoes,Albert Hofman,Jacqueline C. M. Witteman,Peter J. Koudstaal,Diederick E. Grobbee +7 more
TL;DR: Evidence is provided that among elderly subjects an elevated homocysteine level is associated with an increased risk of cardiovascular disease.
Journal ArticleDOI
Early adult to midlife cardiovascular risk factors and cognitive function.
Kristine Yaffe,Eric Vittinghoff,Mark J. Pletcher,Tina D. Hoang,Lenore J. Launer,Rachel A. Whitmer,Laura H. Coker,Stephen Sidney +7 more
TL;DR: C cumulative exposure to CVRFs from early to middle adulthood, especially above recommended guidelines, was associated with worse cognition in midlife, and the meaning of this association and whether it warrants more aggressive treatment of CVRF exposure earlier in life require further investigation.
Journal ArticleDOI
Common variants at 12q14 and 12q24 are associated with hippocampal volume
Joshua C. Bis,Charles DeCarli,Albert V. Smith,Fedde van der Lijn,Fabrice Crivello,Fabrice Crivello,Myriam Fornage,Stephanie Debette,Stephanie Debette,Joshua M. Shulman,Joshua M. Shulman,Helena Schmidt,Velandai Srikanth,Velandai Srikanth,Maaike Schuur,Lei Yu,Seung Hoan Choi,Sigurdur Sigurdsson,Benjamin F.J. Verhaaren,Anita L. DeStefano,Jean-Charles Lambert,Clifford R. Jack,Maksim Struchalin,Jim Stankovich,Carla A. Ibrahim-Verbaas,Debra A. Fleischman,Alex P. Zijdenbos,Tom den Heijer,Bernard Mazoyer,Bernard Mazoyer,Laura H. Coker,Christian Enzinger,Patrick Danoy,Najaf Amin,Konstantinos Arfanakis,Konstantinos Arfanakis,Mark A. van Buchem,Renée F A G de Bruijn,Alexa S. Beiser,Carole Dufouil,Juebin Huang,Margherita Cavalieri,Russell Thomson,Wiro J. Niessen,Wiro J. Niessen,Lori B. Chibnik,Lori B. Chibnik,Gauti Kjartan Gislason,Albert Hofman,Aleksandra Pikula,Philippe Amouyel,Kevin B. Freeman,Thanh G. Phan,Ben A. Oostra,Jason L. Stein,Sarah E. Medland,Sarah E. Medland,Alejandro Arias Vasquez,Derrek P. Hibar,Margaret J. Wright,Barbara Franke,Nicholas G. Martin,Paul M. Thompson,Mike A. Nalls,André G. Uitterlinden,Rhoda Au,Alexis Elbaz,Richard Beare,Richard Beare,John C. van Swieten,Oscar L. Lopez,Tamara B. Harris,Vincent Chouraki,Monique M.B. Breteler,Monique M.B. Breteler,Monique M.B. Breteler,Philip L. De Jager,Philip L. De Jager,James T. Becker,Meike W. Vernooij,David S. Knopman,Franz Fazekas,Philip A. Wolf,Aad van der Lugt,Vilmundur Gudnason,William T. Longstreth,Matthew A. Brown,David A. Bennett,Cornelia M. van Duijn,Cornelia M. van Duijn,Thomas H. Mosley,Reinhold Schmidt,Christophe Tzourio,Christophe Tzourio,Lenore J. Launer,M. Arfan Ikram,Sudha Seshadri +96 more
TL;DR: In this article, a genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10(-7).
Journal ArticleDOI
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium.
Myriam Fornage,Stéphanie Debette,Joshua C. Bis,Helena Schmidt,M. Arfan Ikram,Carole Dufouil,Sigurdur Sigurdsson,Thomas Lumley,Anita L. DeStefano,Franz Fazekas,Henri A. Vrooman,Dean Shibata,Pauline Maillard,Alex P. Zijdenbos,Albert V. Smith,Haukur Gudnason,Renske de Boer,Mary Cushman,Bernard Mazoyer,Gerardo Heiss,Meike W. Vernooij,Christian Enzinger,Nicole L. Glazer,Alexa S. Beiser,David S. Knopman,Margherita Cavalieri,Margherita Cavalieri,Wiro J. Niessen,Tamara B. Harris,Katja Petrovic,Oscar L. Lopez,Rhoda Au,Jean-Charles Lambert,Albert Hofman,Rebecca F. Gottesman,Melissa Garcia,Susan R. Heckbert,Susan R. Heckbert,Larry D. Atwood,Diane J. Catellier,André G. Uitterlinden,Qiong Yang,Nicholas L. Smith,Nicholas L. Smith,Thor Aspelund,Jose R. Romero,Kenneth Rice,Kent D. Taylor,Mike A. Nalls,Jerome I. Rotter,Richey Sharrett,Cornelia M. van Duijn,Philippe Amouyel,Philip A. Wolf,Vilmundur Gudnason,Aad van der Lugt,Eric Boerwinkle,Bruce M. Psaty,Bruce M. Psaty,Sudha Seshadri,Christophe Tzourio,Monique M.B. Breteler,Thomas H. Mosley,Reinhold Schmidt,W. T. Longstreth,Charles DeCarli,Lenore J. Launer +66 more
TL;DR: White matter hyperintensities detectable by magnetic resonance imaging are part of the spectrum of vascular injury associated with aging of the brain and are thought to reflect ischemic damage to the small deep cerebral vessels.