V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
Papers
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Journal ArticleDOI
BAD is a pro-survival factor prior to activation of its pro-apoptotic function.
So Young Seo,Ying Bei Chen,Iva Ivanovska,Ann M. Ranger,Suk Jin Hong,Valina L. Dawson,Stanley J. Korsmeyer,David S. Bellows,Yihru Fannjiang,J. Marie Hardwick +9 more
TL;DR: It is found that endogenous and overexpressed BADL can inhibit cell death in neurons and other cell types, suggesting that BAD is more than an inert death factor in healthy cells; it is also a pro- survival factor, prior to its role in promoting cell death.
Journal ArticleDOI
Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia.
Xiaoling Li,Judith A. Klaus,Jian Zhang,Zhenfeng Xu,Kathleen K. Kibler,Shaida A. Andrabi,Karthik Rao,Zeng Jin Yang,Ted M. Dawson,Valina L. Dawson,Raymond C. Koehler +10 more
TL;DR: In this article, the effect of gene deletion of PARP-1 and PARP2, enzymes activated by DNA oxidative damage, in male mice subjected to 2 h of focal cerebral ischemia was compared.
Book ChapterDOI
Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases
TL;DR: The molecular mechanisms of parthanatos and their role in neurodegenerative diseases are discussed and promising therapeutic interventions within the pathological PAR signaling cascade that could be designed to halt the progression of Neurodegeneration are discussed.
Journal ArticleDOI
Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis
Jing Jin,Matthew D. Smith,Calvin J. Kersbergen,Tae In Kam,Mayuri Viswanathan,Kyle Martin,Ted M. Dawson,Valina L. Dawson,Donald J. Zack,Donald J. Zack,Katharine A. Whartenby,Peter A. Calabresi,Peter A. Calabresi +12 more
TL;DR: EAE can be used to study the pathobiology of optic neuropathy and to examine the preclinical neuroprotective effects of drugs that target activation of neurotoxic A1 astrocytes, and the utility of studying the anterior visual pathway for modeling mechanisms of neuronal injury is highlighted.