V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
Saskia Biskup,Darren J. Moore,Fulvio Celsi,Shinji Higashi,Shinji Higashi,Andrew B. West,Shaida A. Andrabi,Kaisa Kurkinen,Seong-Woon Yu,Joseph M. Savitt,Henry J. Waldvogel,Richard L.M. Faull,Piers C. Emson,Reidun Torp,Ole Petter Ottersen,Ted M. Dawson,Valina L. Dawson +16 more
TL;DR: The association of LRRK2 with a variety of membrane and vesicular structures, membrane-bound organelles, and microtubules suggests an affinity of L RRK2 for lipids or lipid-associated proteins and may suggest a potential role in the biogenesis and/or regulation of vesicle and membranous intracellular structures within the mammalian brain.
Journal ArticleDOI
Role of AIF in caspase-dependent and caspase-independent cell death
TL;DR: The role of Bcl family proteins and poly(ADP-ribose) polymerase-1 signaling in the regulation of these apoptotic pathways are examined and ongoing controversies in this field are addressed.
Journal ArticleDOI
Nitric oxide neurotoxicity.
Valina L. Dawson,Ted M. Dawson +1 more
TL;DR: It is likely that most of the neurotoxic actions of NO are mediated by peroxynitrite (ONOO-), the reaction product from NO and superoxide anion.
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Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
Sean P. Cregan,Andre Fortin,Jason G. MacLaurin,Steven M. Callaghan,Francesco Cecconi,Seong-Woon Yu,Ted M. Dawson,Valina L. Dawson,David S. Park,Guido Kroemer,Ruth S. Slack +10 more
TL;DR: It is demonstrated that p53 can induce neuronal cell death via a caspase-mediated process activated by apoptotic activating factor-1 (Apaf1) and via a delayed onset casp enzyme-independent mechanism, and that apoptosis-inducing factor (AIF) is an important factor involved in the regulation of this caspases-independent neuronal cellDeath.
Journal ArticleDOI
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.
Simone Engelender,Zachary Kaminsky,Xin Guo,Alan H. Sharp,Ravi K. Amaravi,John J. Kleiderlein,Russell L. Margolis,Juan C. Troncoso,Anthony Lanahan,Paul F. Worley,Valina L. Dawson,Ted M. Dawson,Christopher A. Ross,Christopher A. Ross +13 more
TL;DR: It is found that α-synuclein interacts in vivo with synphilin-1 in neurons, and co-transfection of both proteins (but not control proteins) in HEK 293 cells yields cytoplasmic eosinophilic inclusions.