V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
Papers
More filters
Patent
Methods for amelioration of immunodeficiency virus induced neurodegeneration by covering nitric oxide or superoxide concentration
TL;DR: In this article, agents are administered which reduce nitric oxide production by neurons (e.g., nitricoxide synthase inhibitors, calmodulin inhibitors, immunophilin binding drugs) or lower superoxide concentration (i.e., superoxide dismutase gene).
Journal ArticleDOI
USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing
Jae Jin Kim,Seo Yun Lee,Yiseul Hwang,Soyeon Kim,Jee Min Chung,Sangwook Park,Junghyun Yoon,Hansol Yun,Jae-Hoon Ji,Jae-Hoon Ji,Sunyoung Chae,Hyeseong Cho,Chan Gil Kim,Ted M. Dawson,Hongtae Kim,Valina L. Dawson,Ho Chul Kang +16 more
TL;DR: In this paper, the role of USP39, an inactive deubiquitinating enzyme involved in spliceosome assembly, was characterized and shown to be a molecular trigger for liquid demixing in a PAR-coupled N46-dependent manner, thereby directly interacting with the XRCC4/LIG4 complex.
Book ChapterDOI
Excitotoxic programmed cell death involves caspase-independent mechanisms
TL;DR: Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) is an early pathological event in excitotoxicity that leads to a unique form of cell death called parthanatos, which is unique in that it does not involve caspase dependent pathways.
Journal ArticleDOI
The Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in PolgAD257A/D257A Mitochondrial Mutator Mice
Laura-Marie Scott,Senthilkumar S. Karuppagounder,Stewart Neifert,Bong Gu Kang,Hu Wang,Valina L. Dawson,Ted M. Dawson +6 more
TL;DR: It is shown that Parkin-/-/PolgAD257A/D257A mice, a previously reported PD mouse model, fails to reproduce a Parkinsonian phenotype and is reported that parkin loss does not synergize with mitochondrial dysfunction in mouse models of mitochondrial deficits.
Journal ArticleDOI
The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson’s disease
Senthilkumar S. Karuppagounder,Hu Wang,Terence Kelly,Roger Rush,Richard Q Nguyen,Shivani Bisen,Yoko Yamashita,Nicholas Sloan,Brianna Dang,Alexander Sigmon,Hyeun Woo Lee,Shirley Marino Lee,Leslie Watkins,Erica Kim,Saurav Brahmachari,Manoj Kumar,Milton H. Werner,Ted M. Dawson,Valina L. Dawson +18 more
TL;DR: Karuppagounder et al. as discussed by the authors showed that IkT-148009, a brain-penetrant Abelson tyrosine kinase inhibitor with a favorable toxicology profile, was analyzed for therapeutic potential in animal models of slowly progressive, α-synuclein-dependent Parkinson's disease.