V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival
Yunjong Lee,Daniel A. Stevens,Sung Ung Kang,Haisong Jiang,Yun Il Lee,Han Seok Ko,Leslie A. Scarffe,George Essien Umanah,Hojin Kang,Sangwoo Ham,Tae In Kam,Kathleen Allen,Saurav Brahmachari,Jungwoo Wren Kim,Stewart Neifert,Seung Pil Yun,Fabienne C. Fiesel,Wolfdieter Springer,Valina L. Dawson,Joo Ho Shin,Joo Ho Shin,Ted M. Dawson +21 more
TL;DR: A function of PINK1 to direct parkin-PARIS-regulated PGC-1α expression and dopaminergic neuronal survival is uncovered and alleviates PARIS toxicity.
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Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons
Nigel Ramsden,Jessica Perrin,Zhao Ren,Byoung Dae Lee,Nico Zinn,Valina L. Dawson,Danny Tam,Michael P. Bova,Manja Lang,Gerard Drewes,Marcus Bantscheff,Frederique Bard,Ted M. Dawson,Carsten Hopf +13 more
TL;DR: It is demonstrated that CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency, and this work employs a chemoproteomics strategy to identify potent, selective, and metabolically stable L RRK2 inhibitors.
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FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle
Bahman Aghdasi,Keqiang Ye,Adam C. Resnick,Alex S. Huang,Hyo Chol Ha,Xin Guo,Ted M. Dawson,Valina L. Dawson,Solomon H. Snyder +8 more
TL;DR: It is demonstrated that cells from FKBP12-deficient (FKBP12−/−) mice manifest cell cycle arrest in G1 phase and that these cells can be rescued by FK BP12 transfection.
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Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease.
TL;DR: Experimental findings regarding excitotoxicity, PARP activation, and AIF translocation in MPTP toxicity and dopaminergic neuronal cell death are reviewed.
Journal ArticleDOI
Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy
TL;DR: Insight is provided into the process of autophagy in Parkinson's disease pathology by generating mice with the conditional deletion of Atg7 in the dopamine neurons of the substantia nigra pars compacta, other regions of the midbrain, and also the hindbrain.