Valina L. Dawson

TL;DR: It is demonstrated that the excessive aggressiveness and impulsiveness of nNOS knockout mice is caused by selective decrements in serotonin (5-HT) turnover and deficient 5-HT(1A) and 5- HT(1B) receptor function in brain regions regulating emotion.

TL;DR: It is demonstrated here that several PD-linked stressors, including neurotoxins, paraquat, NO, dopamine and iron, induce alterations in parkin solubility and result in its intracellular aggregation, which provides a link between the influence of environmental and intrinsic factors and genetic susceptibilities in PD pathogenesis.

TL;DR: Iduna is defined as a PAR-dependent E3 ligase that regulates cell survival and DNA repair and targets PARP1 for proteasomal degradation.

TL;DR: In cerebellar cultures made from transgenic mice in which the gene for neuronal nitric oxide synthase has been rendered null, LTD induced by glutamate/depolarization conjunctive stimulation was indistinguishable from that in cultures from wild-type mice in terms of amplitude, rate of onset, and duration.

TL;DR: Observations are consistent with reports of biochemical features of apoptosis in neuronal injury models but modest to no protection by caspase inhibitors, and it is likely that AIF is the effector of the morphologic and biochemical events and is the commitment point to neuronal cell death, events that occur prior to caspases activation, thus accounting for the limited effects of casp enzyme inhibitors.