V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
Papers
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Journal ArticleDOI
Taming the clot-buster tPA.
Ted M. Dawson,Valina L. Dawson +1 more
TL;DR: A new approach to treatment minimizes the negative effects of tPA, which increases the risk of hemorrhage and has other deleterious effects.
Book ChapterDOI
Protein Translation in Parkinson's Disease
TL;DR: This chapter summarizes translational defects found in familial PD mutants, and discusses molecular mechanisms involved in the pathology, and also possibilities of targeting the translational machinery for therapeutic intervention in PD.
Posted ContentDOI
Functional dissection of Alzheimer\'s disease brain gene expression signatures in humans and mouse models
Ying-Wooi Wan,Rami Al-Ouran,Carl Grant Mangleburg,Tom V. Lee,Katherine Allison,Sarah M. Neuner,Catherine C. Kaczorowski,Vivek Phillip,Gareth R. Howell,Heidi Martini-Stoica,Hui Zheng,Jungwoo Wren Kim,Valina L. Dawson,Ted M. Dawson,Ping-Chieh Pao,Li-Huei Tsai,Jean-Vianney Haure-Mirande,Minghui Wang,Michelle E. Ehrlich,Hongkang Mei,Xiaoyan Zhong,Paramita Chakrabarty,Yona Levites,Todd E. Golde,Allan I. Levey,Benjamin A. Logsdon,Lara M. Mangravite,Zhandong Liu,Joshua M. Shulman +28 more
TL;DR: Human-mouse overlaps highlight responses to amyloid versus neurofibrillary tangle pathology and further reveal age- and sex-dependent expression signatures for AD progression, as well as pinpoint experimental models for diverse features of AD pathophysiology from human brain transcriptomes.
Journal ArticleDOI
Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection.
TL;DR: Parkinson disease (PD) used to be considered a nongenetic condition, however, the identification of several autosomal dominant and recessive mutations linked to monogenic PD has changed this view as mentioned in this paper.
Book ChapterDOI
Nitric Oxide Neurotoxicity in Primary Neuronal Cultures
Valina L. Dawson,Ted M. Dawson +1 more
TL;DR: Nitric oxide donors can directly induce neurotoxicity in primary cell cultures, and superoxide dismutase is neuroprotective against both N-methyl-D-aspartate and nitric oxide neurotoxicity, implicating the formation of peroxynitrite from the reaction of superoxide anion and Nitric oxide in the genesis of neurotoxicity.