V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
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Posted ContentDOI
Molecular recording of calcium concentration via calcium-dependent protein proximity labeling
Adeline J. H. Yong,Erin Aisenberg,Wei Wang,Ted M. Dawson,Valina L. Dawson,Ruixuan Gao,Helen S. Bateup,Yuh Nung Jan,Nicholas T. Ingolia +8 more
TL;DR: The development of an engineered biotin ligase that combines the power of genetically encoded calcium indicators with protein proximity labeling, Cal-ID, biotinylates nearby proteins within minutes in response to elevated local calcium levels is reported.
Book ChapterDOI
Genetic Models of Familial Parkinson's Disease
TL;DR: This chapter reviews vertebrate α-synuclein transgenic mouse models which have led to substantial advances in understanding the role of α- Synuclein in pathogenic processes that are relevant to Parkinson's disease (PD) and suggests that they can be used to explore the molecular basis of cell death induced by α- synuclein.
Reference EntryDOI
Gaseous Signaling: Nitric Oxide and Carbon Monoxide as Messenger Molecules
TL;DR: The in-depth understanding of how S-nitrosylation can control different physiological and cellular processes will provide valuable information in the development of new therapeutic targets for different diseases in the future.
Posted ContentDOI
Proteome-wide microarray-based screening of PAR-binding proteins
Bong Gu Kang,Sung Ung Kang,Jae Jin Kim,Ji-Sun Kwon,Jean-Philippe Gagné,Seo Yun Lee,Soyeon Kim,Karl L. Sangwon,Shinwon Ha,Jun Seop Jeong,Yun Il Lee,Dongsan Kim,Guy G. Poirier,Ho Chul Kang,Valina L. Dawson,Ted M. Dawson +15 more
TL;DR: The global database of PAR-binding proteins that is established will be a valuable tool for further in-depth analysis of the role of PARylation in a wide range of biological contexts.
Journal ArticleDOI
A high-affinity cocaine binding site associated with the brain acid soluble protein 1
Maged M. Harraz,Adarsha P. Malla,Evan R. Semenza,Maria Shishikura,Manisha Singh,Yun Hwang,In Guk Kang,Young Jun Song,Adele M. Snowman,Pedro Cortés,Senthilkumar S. Karuppagounder,Ted M. Dawson,Valina L. Dawson,Solomon H. Snyder +13 more
TL;DR: This article identified a high-affinity cocaine binding site associated with BASP1 that is involved in mediating the drug's psychotropic actions, suggesting the existence of a high affinity receptor(s) for the drug.