V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.
Jun Bao,Alan H. Sharp,Molly V. Wagster,Mark W. Becher,Gabriele Schilling,Christopher A. Ross,Valina L. Dawson,Ted M. Dawson +7 more
TL;DR: The results suggest that huntingtin interacts with other proteins including CAM and that the expansion of polyGln alters this interaction.
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Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia.
TL;DR: While eNOS contributes only a fraction of total brain NOS activity, during the early minutes of cerebral ischemia prominent NO generation from this isoform occurs, confirming its importance in modulating the process of ischemic injury.
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Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age
Aaron C. Pawlyk,Benoit I. Giasson,Deepak M. Sampathu,Francisco A. Perez,Kah-Leong Lim,Valina L. Dawson,Ted M. Dawson,Richard D. Palmiter,John Q. Trojanowski,Virginia M.-Y. Lee +9 more
TL;DR: By using these highly specific anti-parkin monoclonal antibodies, it was not possible to detect parkin in α-synuclein-containing lesions inα- synucleinopathies, thereby challenging prior inferences about the role of Parkin in movement disorders other than autosomal recessive juvenile parkinsonism.
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Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease
Shiqi Yang,Ayman Koteish,Huizhi Lin,Jiawen Huang,Tania Roskams,Valina L. Dawson,Anna Mae Diehl +6 more
TL;DR: Induction of mechanisms to replace damaged hepatocytes is important for limiting the progression of fatty liver disease and expansion of hepatic progenitor cell populations helps to compensate for the increased turnover of damaged mature hepatocytes.
Journal ArticleDOI
Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases
Nathan A. Berger,Valérie C. Besson,A. Hamid Boulares,Alexander Bürkle,Alberto Chiarugi,Robert S. B. Clark,Nicola J. Curtin,Salvatore Cuzzocrea,Ted M. Dawson,Valina L. Dawson,György Haskó,Lucas Liaudet,Flavio Moroni,Pal Pacher,Peter Radermacher,Andrew L. Salzman,Solomon H. Snyder,Francisco Garcia Soriano,Robert P. Strosznajder,Balazs Sumegi,Raymond A. Swanson,Csaba Szabó +21 more
TL;DR: In this article, the authors present a preclinical and clinical action plan for the repurposing of PARP inhibitors for non-oncological indications, such as acute ischaemic stroke, traumatic brain injury, septic shock, acute pancreatitis, severe asthma and severe acute lung injury.