V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
Papers
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Journal ArticleDOI
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.
Shengnan Zhang,Yu Qing Liu,Chunyu Jia,Yeh Jun Lim,Guoqin Feng,Guoqin Feng,Enquan Xu,Houfang Long,Yasuyoshi Kimura,Youqi Tao,Chunyu Zhao,Chuchu Wang,Zhenying Liu,Jin Jian Hu,Meng Rong Ma,Zhijun Liu,Lin Jiang,Dan Li,Renxiao Wang,Renxiao Wang,Renxiao Wang,Valina L. Dawson,Ted M. Dawson,Yan-Mei Li,Xiaobo Mao,Cong Liu +25 more
TL;DR: Zhang et al. as mentioned in this paper performed an array of biophysical experiments and revealed that lymphocyte activation gene 3 (LAG3) and amyloid precursor-like protein 1 (APLP1) domains commonly use an alkaline surface to bind the acidic C terminus of α-syn.
Journal ArticleDOI
Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE).
TL;DR: The expression profile of late response genes in a model of activity-dependent neuronal survival and neurite outgrowth is reported, which provides a nearly complete and relatively comprehensive differential screening profile that has the potential to be a powerful and useful tool in other fields of study.
Journal ArticleDOI
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
Nikhil Panicker,T. I. Kam,Hu Wang,Stewart Neifert,Shih Ching Chou,Manoj Kumar,Saurav Brahmachari,Aanishaa Jhaldiyal,Jared T. Hinkle,Fatih Akkentli,Xiaobo Mao,Enquan Xu,Senthilkumar S. Karuppagounder,Eric Hsu,Sung Ung Kang,Olga Pletnikova,Juan C. Troncoso,Valina L. Dawson,Ted M. Dawson +18 more
TL;DR: In this paper , Parkin activation was found to contribute to the assembly of an active NLRP3 inflammasome complex via mitochondrial-derived reactive oxygen species (mitoROS) generation through the accumulation of another parkin ubiquitination substrate, ZNF746/PARIS.
Patent
Method of using selective parp inhibitors to prevent or treat neurotoxicity
Mikael J. L. Eliasson,Kenji Sampei,Allen S. Mandir,Patricia D. Hurn,Richard J. Traystman,Jun Bao,Andrew A. Pieper,Ted M. Dawson,Solomon H. Snyder,Valina L. Dawson +9 more
TL;DR: In this article, selective inhibitors of poly(ADPribose) polymerase were used to prevent neutral tissue damage resulting for ischemia and reperfusion injury or neurodegenerative diseases.
Journal ArticleDOI
Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons.
Manoj Kumar,Jesús Acevedo-Cintrón,Aanishaa Jhaldiyal,Hu Wang,Shaida A. Andrabi,Stephen M. Eacker,Senthilkumar S. Karuppagounder,Saurav Brahmachari,Rong Chen,Hyesoo Kim,Han Seok Ko,Valina L. Dawson,Ted M. Dawson +12 more
TL;DR: It is shown that although there are defects in mitophagy in human DA neurons lacking PARKIN, the mitochondrial deficits are primarily due to defects in mitochondrial biogenesis that are driven by the upregulation of PARIS and the subsequent downregulation of PGC-1α.