V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
Papers
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Journal ArticleDOI
Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons
Yingchao Xue,Yingchao Xue,Xiping Zhan,Shisheng Sun,Senthilkumar S. Karuppagounder,Shuli Xia,Shuli Xia,Valina L. Dawson,Ted M. Dawson,John Laterra,Jianmin Zhang,Mingyao Ying,Mingyao Ying +12 more
TL;DR: These findings established the first mRNA‐driven strategy for efficient iPSC differentiation to mDA neurons, and identified the NM‐II complex as a positive modulator of Atoh1‐driven neuron differentiation.
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STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
Jared T. Hinkle,Jaimin Patel,Nikhil Panicker,Senthilkumar S. Karuppagounder,Devanik Biswas,Bonn Belingon,Rong Chen,Saurav Brahmachari,Olga Pletnikova,Juan C. Troncoso,Valina L. Dawson,Ted M. Dawson +11 more
TL;DR: The results suggest that STING inhibition may be therapeutic in idiopathic PD and possibly other human α-synucleinopathies, and it is shown that αSyn aggregates can increase STING expression and augment canonical STING activation, suggesting a possible generalized propensity for exaggerated antiviral responses in neurological states with STING elevation.
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Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain
Marc F. Poitras,David W. Koh,Seong-Woon Yu,Shaida A. Andrabi,Allen S. Mandir,Guy G. Poirier,Valina L. Dawson,Ted M. Dawson +7 more
TL;DR: The subcellular segregation of PARG in the mitochondria and PARP-1 in the nucleus suggests that PARG translocation is necessary for their functional interaction, further demonstrating a functional interaction of PARp-1 and PARg in the brain.
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Circadian Locomotor Analysis of Male Mice Lacking the Gene for Neuronal Nitric Oxide Synthase (nNOS
Lance J. Kriegsfeld,Gregory E. Demas,Samuel E. Lee,Ted M. Dawson,Valina L. Dawson,Randy J. Nelson +5 more
TL;DR: Findings suggest that NO from neurons might not be necessary for photic entrainment of circadian rhythms, as compared to general NOS inhibitors.
Journal ArticleDOI
Advances in Neuronal Cell Death 2007
TL;DR: Combined, the current data indicate that PAR is a powerful death signal and Regulation of PAR signaling may be a useful therapeutic intervention to reduce stroke-mediated damage.