V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
Papers
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Journal ArticleDOI
PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease
Areum Jo,Areum Jo,Yunjong Lee,Tae In Kam,Sung Ung Kang,Stewart Neifert,Senthilkumar S. Karuppagounder,Rin Khang,Hojin Kang,Hojin Kang,Hyejin Park,Shih Ching Chou,Sungtaek Oh,Haisong Jiang,Deborah A. Swing,Sangwoo Ham,Sheila K. Pirooznia,George K.E. Umanah,Xiaobo Mao,Manoj Kumar,Han Seok Ko,Ho Chul Kang,Byoung Dae Lee,Yun Il Lee,Shaida A. Andrabi,Chi Hu Park,Ji-Yeong Lee,Hanna Kim,Hyein Kim,Hyo Jung Kim,Jin Whan Cho,Sun Ha Paek,Chan Hyun Na,Lino Tessarollo,Valina L. Dawson,Ted M. Dawson,Joo Ho Shin +36 more
TL;DR: In this paper, Farnesol was identified as an inhibitor of PARIS and showed that PARIS farnesylation is decreased in the substantia nigra of patients with Parkinson's disease, suggesting that reduced PARIS may play a role in PD.
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Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis.
Jian Zhang,Xiaoling Li,Herman Kwansa,Yun Tai Kim,Liye Yi,Gina Hong,Shaida A. Andrabi,Valina L. Dawson,Ted M. Dawson,Raymond C. Koehler,Zeng Jin Yang +10 more
TL;DR: It is demonstrated that acidosis can directly amplify neuronal parthanatos in the absence of ischemia through acid-sensitive ion channel-1a, which further supportParthanatos as one of the mechanisms by which ischemIA-associated tissue acidosis augments cell death.
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Targeting Parthanatos in Ischemic Stroke.
TL;DR: Parthanatos is a cell death signaling pathway in which excessive oxidative damage to DNA leads to over-activation of poly(ADP-ribose) polymerase (PARP) as mentioned in this paper.
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Recent advances in our understanding of Parkinson's disease
TL;DR: Common potential mechanisms in the development of PD are being unveiled, that is, defects in mitochondrial function as well as protein folding and degradation through the ubiquitin–proteosomal system leading to cell death.
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Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes.
TL;DR: The protective effects of the eIF4E/eIF4G interaction inhibitor 4EGI-1, in preventing neurodegenerative phenotypes in G2019S LRRK2 flies, is reported and how the findings and those of other groups provide a framework to begin investigating the mechanistic impact of L RRK2 on translation are discussed.