V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
Papers
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Journal ArticleDOI
Integrative genome-wide analysis of dopaminergic neuron-specific PARIS expression in Drosophila dissects recognition of multiple PPAR-γ associated gene regulation.
TL;DR: In this paper, Parkin interacting substrate (PARIS) was identified as a co-substrate of parkin and PINK1 that leads to Parkinson's disease (PD) by disrupting mitochondrial biogenesis through peroxisome proliferator-activated receptor gamma (PPARγ) coactivator suppression.
Patent
Long-acting glp-1r agonist as a therapy of neurological and neurodegenerative conditions
TL;DR: In this article, the authors present compositions and methods for treating neurodegenerative conditions using GLP-1r agonists, which have neuroprotective and disease modifying effects on the central nervous system.
Book ChapterDOI
Genetics of parkinson’s disease
TL;DR: The recent identification of several genes and gene loci linked to familial forms of Parkinson's disease (PD) has contributed significantly to our understanding of the genetic contribution in PD as mentioned in this paper.
Journal ArticleDOI
Identification by mRNA differential display of two up-regulated genes as candidate mediators of AIDS dementia.
Brigitte Wildemann,Juergen Haas,Karoline Stingele,B. Storch-Hagenlocher,Justin C. McArthur,Ted M. Dawson,Valina L. Dawson +6 more
TL;DR: Altered expression of known genes not previously associated with the pathogenesis of AIDS dementia may contribute to AIDS dementia through the enhancement of microglial activation and immunologic nitric oxide synthase activity by abnormal neurotrophic regulation and interference with membrane excitability through disturbance of local ion homeostasis.
Journal ArticleDOI
Pharmacologic inhibition of MIF nuclease: A new treatment paradigm to treat cell death
TL;DR: This research presents a novel and scalable approach to regenerative medicine that combines cell reprograming, which has the potential to improve the quality of life of patients and also contributes to their prognosis.