V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
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Free radicals as mediators of neuronal injury
TL;DR: Therapeutic approaches which limit oxidative stress may be potentially beneficial in several neurological diseases, including amyotrophic lateral sclerosis and Parkinson's disease.
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Neurobiology of nitric oxide
TL;DR: Nitric oxide may play a role in the neurotransmitter release, neural development, synaptic plasticity, and regulation of gene expression, and is implicated in a variety of neurological disorders.
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Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.
Hongmin Wang,Seong-Woon Yu,David W. Koh,Jasmine Lew,Carmen Coombs,William J. Bowers,Howard J. Federoff,Guy G. Poirier,Ted M. Dawson,Valina L. Dawson +9 more
TL;DR: It is reported here that apoptosis-inducing factor (AIF) mediates PARP-1-dependent glutamate excitotoxicity in a caspase-independent manner after translocation from the mitochondria to the nucleus.
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Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity
Mirella Gonzalez-Zulueta,Lisa M. Ensz,Galina Mukhina,Russell M. Lebovitz,Ralf M. Zwacka,John F. Engelhardt,Larry W. Oberley,Valina L. Dawson,Ted M. Dawson +8 more
TL;DR: MnSOD is a major protective protein that appears to be essential for the resistance of nNOS neurons in cortical cultures to NMDA mediated neurotoxicity.
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Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.
Jean François Haince,Sergei Kozlov,Valina L. Dawson,Ted M. Dawson,Michael J. Hendzel,Martin F. Lavin,Guy G. Poirier +6 more
TL;DR: This study suggests that poly(ADP-ribose) might serve as a DNA damage sensory molecule that is critical for early DNA damage signaling, and demonstrates a functional and physical interaction between the major DSB signaling kinase, ATM and poly( ADP- ribose)ation by PARP-1, a key enzyme of chromatin remodeling.