V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
Papers
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Journal ArticleDOI
DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders.
Yan Jouroukhin,Yusuke Kageyama,Varvara Misheneva,A. V. Shevelkin,Shaida A. Andrabi,Emese Prandovszky,Robert H. Yolken,Valina L. Dawson,Ted M. Dawson,Susan Aja,Hiromi Sesaki,Mikhail V. Pletnikov +11 more
TL;DR: The results suggest that DISC1 may be involved in the regulation of lactate production in astrocytes to support neuronal activity and associated behaviors in patients with major psychiatric illnesses.
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Lessons from Drosophila models of DJ-1 deficiency.
TL;DR: DJ-1-deficient fly models further highlight the utility of Drosophila as an important tool for elucidating protein function and for modeling neurodegenerative disease.
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New synaptic and molecular targets for neuroprotection in Parkinson's disease
Paolo Calabresi,Massimiliano Di Filippo,Antongiulio Gallina,Yingfei Wang,Jeannette N. Stankowski,Barbara Picconi,Valina L. Dawson,Ted M. Dawson +7 more
TL;DR: New potential molecular and synaptic striatal targets for the development of both symptomatic and neuroprotective strategies for PD are described and the interaction between adenosine A2A receptors and dopamine D2 receptors, on the role of a correct assembly of NMDA receptors, and on the sGC/cGMP/PKG pathway is focused on.
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Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos.
TL;DR: This work sought to identify small molecules that could be neuroprotective by targeting the parthanatos pathway, involving overactivation of PARP‐1.
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Glutamate-stimulated calcium activation of Ras/Erk pathway mediated by nitric oxide.
TL;DR: It is proposed that NO is a key link between NMDA-mediated increases in cytoplasmic calcium and activity-dependent long-term changes such as differentiation, survival and synaptic plasticity.