V
Valina L. Dawson
Researcher at Johns Hopkins University School of Medicine
Publications - 477
Citations - 88024
Valina L. Dawson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkin. The author has an hindex of 136, co-authored 451 publications receiving 76986 citations. Previous affiliations of Valina L. Dawson include University of Baltimore & Hospital of the University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases
Jeanne M.M. Tan,Esther Wong,Donald S. Kirkpatrick,Olga Pletnikova,Han Seok Ko,Shiam Peng Tay,Michelle W L Ho,Juan C. Troncoso,Steven P. Gygi,Michael K. Lee,Valina L. Dawson,Ted M. Dawson,Kah-Leong Lim +12 more
TL;DR: The results provide a novel mechanistic route that underlies the life cycle of an inclusion body and indicate that K63-linked ubiquitin chains may represent a common denominator underlying inclusions biogenesis, as well as a general cellular strategy for defining cargo destined for the autophagic system.
Journal ArticleDOI
Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41.
D. Cory Adamson,Brigitte Wildemann,Masayuki Sasaki,Jonathan D. Glass,Justin C. McArthur,Vesselin I. Christov,Ted M. Dawson,Valina L. Dawson +7 more
TL;DR: Indirect mechanisms are implicated in the pathogenesis of the dementia associated with human immunodeficiency virus-type 1 (HIV-1), and gp41-induced NO formation may contribute to the severe cognitive dysfunction associated with HIV-1 infection.
Journal ArticleDOI
Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice
TL;DR: Primary cortical cultures from transgenic neuronal NO synthase (NOS) null (nNOS-) mice are used to establish NO as a mediator of NMDA and hypoxic neurotoxicity, confirming observations that NO-mediated neurotoxicity is associated primarily with activation of the NMDA receptor.
Journal ArticleDOI
Oxidative stress and genetics in the pathogenesis of Parkinson's disease.
TL;DR: Recent advances in the understanding of the role of genetics and oxidative stress in the pathogenesis of PD are reviewed.
Journal ArticleDOI
Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities
TL;DR: This review describes the multistep course of parthanatos and its dependence on PAR signalling and nuclear AIF translocation, and discusses potential targets in theparthanatos cascade as promising avenues for the development of novel, disease‐modifying, therapeutic agents.