William W. Busse

TL;DR: Several transcriptional targets of IL-5 and GM-CSF in human eosinophils are identified and suggest that a number of protein products are critical to the responsiveness of airway eosInophils.

TL;DR: Asthmatic patients who smoke, and are not treated with ICSs, have a greater decline in lung function than asthmatic Patients who do not smoke and the benefits of therapy with inhaled budesonide on preventing lung function decline are similar in smokers and nonsmokers with mild persistent asthma.

TL;DR: Although the diagnosis of asthma is often based on clinical information, it is important to pursue objective criteria as well, including an evaluation for reversibility of airflow obstruction and bronchial hyperresponsiveness, an area with new diagnostic approaches.

TL;DR: This article interprets current evidence for biomarkers of eosinophilic or type 2-high asthma so that clinicians can determine potential treatments for patients based on knowledge of their effectiveness in specific asthma phenotypes and assess clinical data on the efficacy, safety, and mechanisms of action of approved and pipeline biologic therapies.