William W. Busse

TL;DR: Asthmatic subjects are differentially affected by obesity based on whether they had asthma early (<12 years of age) or later in life, and this results highlight the need to understand obesity as a comorbidity that affects specific clinical phenotypes and not all asthma subjects alike.

TL;DR: It is concluded that rhinovirus upper respiratory infection significantly augments immediate and late allergic responses in the airways of allergic individuals after local antigen challenge, suggesting that one mechanism of increased asthma during a cold is an accentuation of allergic responses to the airway which may then contribute to bronchial inflammation.

TL;DR: A well-designed DPI and an appropriate powder formulation can optimize the effectiveness of inhaled drug therapy and recent advances in formulation technology can increase lung dose and reduce its variability.

TL;DR: Single escalating doses of MEDI-563 had an acceptable safety profile and resulted in marked reduction of PB eosinophil counts within 24 hours after dosing, as well as C-reactive protein levels, which returned to baseline by study end.

TL;DR: Severe asthma is associated with a predominance of MC(TC) in the airway submucosa and epithelium, and the data suggest an altered and active MC population contributes to SA pathology.