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William W. Busse
Researcher at University of Wisconsin-Madison
Publications - 740
Citations - 62685
William W. Busse is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Asthma & Eosinophil. The author has an hindex of 115, co-authored 697 publications receiving 56703 citations. Previous affiliations of William W. Busse include National Institutes of Health & University at Buffalo.
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Journal ArticleDOI
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
Xingnan Li,Gregory A. Hawkins,Elizabeth J. Ampleford,Wendy C. Moore,Huashi Li,Annette T. Hastie,Timothy D. Howard,Homer A. Boushey,William W. Busse,William J. Calhoun,Mario Castro,Serpil C. Erzurum,Elliot Israel,Robert F. Lemanske,Stanley J. Szefler,Stephen I. Wasserman,Sally E. Wenzel,Stephen P. Peters,Deborah A. Meyers,Eugene R. Bleecker +19 more
TL;DR: Genes involved in airway structure/remodeling are associated with lung function in both general populations and asthmatic subjects and genes associated with asthma susceptibility are distinct from those genes associatedwith asthma susceptibility.
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Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma
TL;DR: It is hypothesize that the decreased use of aspirin in favor of acetaminophen, due to the association of aspirin with Reye's syndrome during febrile respiratory infections, may be contributing to these trends in the United States.
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An Airway Epithelial iNOS-DUOX2-Thyroid Peroxidase Metabolome Drives Th1/Th2 Nitrative Stress in Human Severe Asthma
Nipasiri Voraphani,Mark T. Gladwin,A U Contreras,Naftali Kaminski,John Tedrow,Jadranka Milosevic,Eugene R. Bleecker,Deborah A. Meyers,Anuradha Ray,Prabir Ray,Serpil C. Erzurum,William W. Busse,Jing Zhao,John B. Trudeau,Sally E. Wenzel +14 more
TL;DR: A novel iNOS–DUOX2–TPO–NO2• metabolome drives nitrative stress in HAEC and likely in SA, supporting a critical role for H2O2, but not peroxynitrite, in 3NT generation.
Journal Article
Eosinophils Bind Rhinovirus and Activate Virus-Specific T Cells
Zeev T. Handzel,William W. Busse,Julie B. Sedgwick,Rose F. Vrtis,Wai Ming Lee,Elizabeth A. Kelly,James E. Gern +6 more
TL;DR: It is suggested that EOS could participate in RV-induced immune responses through Ag presentation and T cell activation, and may play an important role in the initiation of antiviral T cell responses, and these effects could also contribute to enhanced airway inflammation and increased asthma symptoms in susceptible individuals.
Journal ArticleDOI
Effect of omalizumab on peripheral blood eosinophilia in allergic asthma
Marc Massanari,Stephen T. Holgate,William W. Busse,Pablo Jimenez,Farid Kianifard,Robert K. Zeldin +5 more
TL;DR: The findings from a pooled analysis of data from five randomized, double-blind, placebo-controlled studies in patients with moderate-to-severe persistent allergic asthma are consistent with earlier reports of the inhibitory effect of omalizumab on eosinophils.