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Showing papers by "Wolfgang Wagner published in 2011"


Journal ArticleDOI
TL;DR: The International Soil Moisture Network (ISMN) as discussed by the authors is a centralized data hosting facility where globally available in situ soil moisture measurements from operational networks and validation campaigns are collected, harmonized, and made available to users.
Abstract: . In situ measurements of soil moisture are invaluable for calibrating and validating land surface models and satellite-based soil moisture retrievals. In addition, long-term time series of in situ soil moisture measurements themselves can reveal trends in the water cycle related to climate or land cover change. Nevertheless, on a worldwide basis the number of meteorological networks and stations measuring soil moisture, in particular on a continuous basis, is still limited and the data they provide lack standardization of technique and protocol. To overcome many of these limitations, the International Soil Moisture Network (ISMN; http://www.ipf.tuwien.ac.at/insitu ) was initiated to serve as a centralized data hosting facility where globally available in situ soil moisture measurements from operational networks and validation campaigns are collected, harmonized, and made available to users. Data collecting networks share their soil moisture datasets with the ISMN on a voluntary and no-cost basis. Incoming soil moisture data are automatically transformed into common volumetric soil moisture units and checked for outliers and implausible values. Apart from soil water measurements from different depths, important metadata and meteorological variables (e.g., precipitation and soil temperature) are stored in the database. These will assist the user in correctly interpreting the soil moisture data. The database is queried through a graphical user interface while output of data selected for download is provided according to common standards for data and metadata. Currently (status May 2011), the ISMN contains data of 19 networks and more than 500 stations located in North America, Europe, Asia, and Australia. The time period spanned by the entire database runs from 1952 until the present, although most datasets have originated during the last decade. The database is rapidly expanding, which means that both the number of stations and the time period covered by the existing stations are still growing. Hence, it will become an increasingly important resource for validating and improving satellite-derived soil moisture products and studying climate related trends. As the ISMN is animated by the scientific community itself, we invite potential networks to enrich the collection by sharing their in situ soil moisture data.

914 citations


Journal ArticleDOI
TL;DR: In this article, the retrieval characteristics of passive (AMSR-E) and active (ASCAT) microwave satellite estimates are combined to produce an improved soil moisture product. But the results of the satellite-based passive and active microwave sensors have the potential to offer improved estimates of surface soil moisture at global scale.
Abstract: . Combining information derived from satellite-based passive and active microwave sensors has the potential to offer improved estimates of surface soil moisture at global scale. We develop and evaluate a methodology that takes advantage of the retrieval characteristics of passive (AMSR-E) and active (ASCAT) microwave satellite estimates to produce an improved soil moisture product. First, volumetric soil water content (m3 m−3) from AMSR-E and degree of saturation (%) from ASCAT are rescaled against a reference land surface model data set using a cumulative distribution function matching approach. While this imposes any bias of the reference on the rescaled satellite products, it adjusts them to the same range and preserves the dynamics of original satellite-based products. Comparison with in situ measurements demonstrates that where the correlation coefficient between rescaled AMSR-E and ASCAT is greater than 0.65 ("transitional regions"), merging the different satellite products increases the number of observations while minimally changing the accuracy of soil moisture retrievals. These transitional regions also delineate the boundary between sparsely and moderately vegetated regions where rescaled AMSR-E and ASCAT, respectively, are used for the merged product. Therefore the merged product carries the advantages of better spatial coverage overall and increased number of observations, particularly for the transitional regions. The combination method developed has the potential to be applied to existing microwave satellites as well as to new missions. Accordingly, a long-term global soil moisture dataset can be developed and extended, enhancing basic understanding of the role of soil moisture in the water, energy and carbon cycles.

606 citations


Journal ArticleDOI
TL;DR: In this article, a comprehensive assessment of the reliability of soil moisture estimations from the Advanced SCATterometer (ASCAT) and AMSR-E sensors is carried out by using observed and modelled soil moisture data over 17 sites located in 4 countries across Europe (Italy, Spain, France and Luxembourg).

509 citations


Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah3, A. A. Abdelalim4  +3104 moreInstitutions (190)
TL;DR: In this paper, the particle multiplicity, its dependence on transverse momentum and pseudorapidity and the relationship between the mean transversal momentum and the charged-particle multiplicity are measured.
Abstract: Measurements are presented from proton-proton collisions at centre-of-mass energies of root s = 0.9, 2.36 and 7 TeV recorded with the ATLAS detector at the LHC. Events were collected using a single-arm minimum-bias trigger. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the relationship between the mean transverse momentum and charged-particle multiplicity are measured. Measurements in different regions of phase space are shown, providing diffraction-reduced measurements as well as more inclusive ones. The observed distributions are corrected to well-defined phase-space regions, using model-independent corrections. The results are compared to each other and to various Monte Carlo (MC) models, including a new AMBT1 pythia6 tune. In all the kinematic regions considered, the particle multiplicities are higher than predicted by the MC models. The central charged-particle multiplicity per event and unit of pseudorapidity, for tracks with p(T) > 100 MeV, is measured to be 3.483 +/- 0.009 (stat) +/- 0.106 (syst) at root s = 0.9 TeV and 5.630 +/- 0.003 (stat) +/- 0.169 (syst) at root s = 7 TeV.

435 citations


Journal ArticleDOI
26 Oct 2011
TL;DR: An Epigenetic-Aging-Signature is identified which is applicable for many tissues to predict donor age and can be used to predict donors age in various cell preparations - for example in forensic analysis.
Abstract: All tissues of the organism are affected by aging. This process is associated with epigenetic modifications such as methylation changes at specific cytosine residues in the DNA (CpG sites). Here, we have identified an Epigenetic-Aging-Signature which is applicable for many tissues to predict donor age. DNA-methylation profiles of various cell types were retrieved from public data depositories - all using the HumanMethylation27 BeadChip platform which represents 27,578 CpG sites. Five datasets from dermis, epidermis, cervical smear, T-cells and monocytes were used for Pavlidis Template Matching to identify 19 CpG sites that are continuously hypermethylated upon aging (R > 0.6; p-value <10−13). Four of these CpG sites (associated with the genes NPTX2, TRIM58, GRIA2 and KCNQ1DN) and an additional hypomethylated CpG site (BIRC4BP) were implemented in a model to predict donor age. This Epigenetic-Aging-Signature was tested on a validation group of eight independent datasets corresponding to several cell types from different tissues. Overall, the five CpG sites revealed age-associated DNA-methylation changes in all tissues. The average absolute difference between predicted and real chronological age was about 11 years. This method can be used to predict donor age in various cell preparations - for example in forensic analysis.

265 citations


Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah3, A. A. Abdelalim4  +3072 moreInstitutions (177)
TL;DR: A measurement of the production cross-section for top quark pairs (t (t) over bar) in pp collisions at root s = 7 TeV is presented in this article using data recorded with the ATLAS detector at the Large Hadron Co.
Abstract: A measurement of the production cross-section for top quark pairs (t (t) over bar) in pp collisions at root s = 7 TeV is presented using data recorded with the ATLAS detector at the Large Hadron Co ...

200 citations


Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah3, A. A. Abdelalim4  +3163 moreInstitutions (177)
TL;DR: In this article, the anti-kt algorithm is used to identify jets, with two jet resolution parameters, R = 0.4 and 0.6, and the dominant uncertainty comes from the jet energy scale, which is determined to within 7% for central jets above 60 GeV transverse momentum.
Abstract: Jet cross sections have been measured for the first time in proton-proton collisions at a centre-of-mass energy of 7 TeV using the ATLAS detector. The measurement uses an integrated luminosity of 17 nb-1 recorded at the Large Hadron Collider. The anti-kt algorithm is used to identify jets, with two jet resolution parameters, R = 0.4 and 0.6. The dominant uncertainty comes from the jet energy scale, which is determined to within 7% for central jets above 60 GeV transverse momentum. Inclusive single-jet differential cross sections are presented as functions of jet transverse momentum and rapidity. Dijet cross sections are presented as functions of dijet mass and the angular variable $\chi$. The results are compared to expectations based on next-to-leading-order QCD, which agree with the data, providing a validation of the theory in a new kinematic regime.

177 citations


Journal ArticleDOI
TL;DR: It is established that an actin-based motor moves ER within animal cells, and the mechanism for ER localization to Purkinje neuron spines is uncovered, a prerequisite for synaptic plasticity.
Abstract: The role of actin-based motors and the mode of endoplasmic reticulum (ER) transport into spines had remained unclear Myosin-Va is now shown to act as a point-to-point ER transporter into dendritic spines

171 citations


Journal ArticleDOI
Georges Aad1, Brad Abbott2, J. Abdallah3, A. A. Abdelalim4  +3139 moreInstitutions (192)
TL;DR: In this paper, a measurement of the cross section for the inclusive production of isolated prompt photons in pp collisions at a center-of-mass energy root s = 7 TeV is presented.
Abstract: A measurement of the cross section for the inclusive production of isolated prompt photons in pp collisions at a center-of-mass energy root s = 7 TeV is presented. The measurement covers the pseudorapidity ranges vertical bar eta(gamma)vertical bar < 1: 37 and 1: 52 <= vertical bar eta(gamma)vertical bar < 1: 81 in the transverse energy range 15 <= E-T(gamma) < 100 GeV. The results are based on an integrated luminosity of 880 nb(-1), collected with the ATLAS detector at the Large Hadron Collider. Photon candidates are identified by combining information from the calorimeters and from the inner tracker. Residual background in the selected sample is estimated from data based on the observed distribution of the transverse isolation energy in a narrow cone around the photon candidate. The results are compared to predictions from next-to-leading-order perturbative QCD calculations.

168 citations


Journal ArticleDOI
25 Sep 2011
TL;DR: Culture expansion of MSC has profound functional implications - these are hardly reflected by genomic instability but they are associated with highly reproducible DNA-methylation changes which correlate with repressive histone marks, therefore replicative senescence seems to be epigenetically controlled.
Abstract: Cells in culture undergo replicative senescence. In this study, we analyzed functional, genetic and epigenetic sequels of long-term culture in human mesenchymal stem cells (MSC). Already within early passages the fibroblastoid colonyforming unit (CFU-f) frequency and the differentiation potential of MSC declined significantly. Relevant chromosomal aberrations were not detected by karyotyping and SNP-microarrays. Subsequently, we have compared DNA-methylation profiles with the Infinium HumanMethylation27 Bead Array and the profiles differed markedly in MSC derived from adipose tissue and bone marrow. Notably, all MSC revealed highly consistent senescence-associated modifications at specific CpG sites. These DNA-methylation changes correlated with histone marks of previously published data sets, such as trimethylation of H3K9, H3K27 and EZH2 targets. Taken together, culture expansion of MSC has profound functional implications - these are hardly reflected by genomic instability but they are associated with highly reproducible DNA-methylation changes which correlate with repressive histone marks. Therefore replicative senescence seems to be epigenetically controlled.

167 citations


Journal ArticleDOI
Georges Aad, Brad Abbott, J. Abdallah1, A. A. Abdelalim2  +3207 moreInstitutions (193)
TL;DR: The first search for supersymmetry in final states containing one isolated electron or muon, jets, and missing transverse momentum from 7 TeV proton-proton collisions at the LHC was presented in this article.
Abstract: This Letter presents the first search for supersymmetry in final states containing one isolated electron or muon, jets, and missing transverse momentum from sqrt{s} = 7 TeV proton-proton collisions at the LHC. The data were recorded by the ATLAS experiment during 2010 and correspond to a total integrated luminosity of 35 pb-1. No excess above the standard model background expectation is observed. Limits are set on the parameters of the minimal supergravity framework, extending previous limits. For A_0 = 0 GeV, tan beta = 3, mu > 0 and for equal squark and gluino masses, gluino masses below 700 GeV are excluded at 95% confidence level.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, J. Abdallah3, A. A. Abdelalim4  +3078 moreInstitutions (188)
TL;DR: In this article, a search for new interactions and resonances produced in LHC proton-proton (pp) collisions at a centre-of-mass energy root s = 7 TeV was performed with the ATLAS detector.
Abstract: A search for new interactions and resonances produced in LHC proton-proton (pp) collisions at a centre-of-mass energy root s = 7 TeV was performed with the ATLAS detector. Using a dataset with an integrated luminosity of 36 pb(-1), dijet mass and angular distributions were measured up to dijet masses of similar to 3.5 TeV and were found to be in good agreement with Standard Model predictions. This analysis sets limits at 95% CL on various models for new physics: an excited quark is excluded for mass between 0.60 and 2.64 TeV, an axigluon hypothesis is excluded for axigluon masses between 0.60 and 2.10 TeV and quantum black holes are excluded in models with six extra space-time dimensions for quantum gravity scales between 0.75 and 3.67 TeV. Production cross section limits as a function of dijet mass are set using a simplified Gaussian signal model to facilitate comparisons with other hypotheses. Analysis of the dijet angular distribution using a novel technique simultaneously employing the dijet mass excludes quark contact interactions with a compositeness scale 3 below 9.5 TeV.

Journal ArticleDOI
TL;DR: The International Association for the Properties of Water and Steam (IAPWS) as discussed by the authors presented new reference equations for the sublimation pressure and melting pressure of ice Ih as a function of temperature.
Abstract: New reference equations, adopted by the International Association for the Properties of Water and Steam (IAPWS), are presented for the sublimation pressure and melting pressure of ice Ih as a function of temperature. These equations are based on input values derived from the phase-equilibrium condition between the IAPWS-95 scientific standard for thermodynamic properties of fluid H2O and the equation of state of H2O ice Ih adopted by IAPWS in 2006, making them thermodynamically consistent with the bulk-phase properties. Compared to the previous IAPWS formulations, which were empirical fits to experimental data, the new equations have significantly less uncertainty. The sublimation-pressure equation covers the temperature range from 50 K to the vapor–liquid–solid triple point at 273.16 K. The ice Ih melting-pressure equation describes the entire melting curve from 273.16 K to the ice Ih–ice III–liquid triple point at 251.165 K. For completeness, we also give the IAPWS melting-pressure equation for ice III, which is slightly adjusted to agree with the ice Ih melting-pressure equation at the corresponding triple point, and the unchanged IAPWS melting-pressure equations for ice V, ice VI, and ice VII.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, J. Abdallah3, A. A. Abdelalim4  +3098 moreInstitutions (189)
TL;DR: In this paper, the authors used a minimum bias trigger to select proton-proton collisions at center-of-mass energies of 900 GeV and 7 TeV at the LHC.
Abstract: Measurements of charged particle distributions, sensitive to the underlying event, have been performed with the ATLAS detector at the LHC. The measurements are based on data collected using a minimum-bias trigger to select proton-proton collisions at center-of-mass energies of 900 GeV and 7 TeV. The "underlying event" is defined as those aspects of a hadronic interaction attributed not to the hard scattering process, but rather to the accompanying interactions of the rest of the proton. Three regions are defined in azimuthal angle with respect to the highest transverse momentum charged particle in the event, such that the region transverse to the dominant momentum-flow is most sensitive to the underlying event. In each of these regions, distributions of the charged particle multiplicity, transverse momentum density, and average pT are measured. The data show generally higher underlying event activity than that predicted by Monte Carlo models tuned to pre-LHC data.

Journal ArticleDOI
08 Feb 2011-PLOS ONE
TL;DR: Epigenetic modifications at specific CpG sites support the notion that aging represents a coordinated developmental mechanism that seems to be regulated in a cell type specific manner.
Abstract: Epigenetic modifications of cytosine residues in the DNA play a critical role for cellular differentiation and potentially also for aging In mesenchymal stromal cells (MSC) from human bone marrow we have previously demonstrated age-associated methylation changes at specific CpG-sites of developmental genes In continuation of this work, we have now isolated human dermal fibroblasts from young ( 60 years) for comparison of their DNA methylation profiles using the Infinium HumanMethylation27 assay In contrast to MSC, fibroblasts could not be induced towards adipogenic, osteogenic and chondrogenic lineage and this is reflected by highly significant differences between the two cell types: 766 CpG sites were hyper-methylated and 752 CpG sites were hypo-methylated in fibroblasts in comparison to MSC Strikingly, global DNA methylation profiles of fibroblasts from the same dermal region clustered closely together indicating that fibroblasts maintain positional memory even after in vitro culture 75 CpG sites were more than 15% differentially methylated in fibroblasts upon aging Very high hyper-methylation was observed in the aged group within the INK4A/ARF/INK4b locus and this was validated by pyrosequencing Age-associated DNA methylation changes were related in fibroblasts and MSC but they were often regulated in opposite directions between the two cell types In contrast, long-term culture associated changes were very consistent in fibroblasts and MSC Epigenetic modifications at specific CpG sites support the notion that aging represents a coordinated developmental mechanism that seems to be regulated in a cell type specific manner

Journal ArticleDOI
TL;DR: In this article, the authors examined whether the assimilation of remotely sensed near-surface soil moisture observations might benefit an operational hydrological model, specifically Meteo-France's SAFRAN-ISBA-MODCOU (SIM) model.
Abstract: . This study examines whether the assimilation of remotely sensed near-surface soil moisture observations might benefit an operational hydrological model, specifically Meteo-France's SAFRAN-ISBA-MODCOU (SIM) model. Soil moisture data derived from ASCAT backscatter observations are assimilated into SIM using a Simplified Extended Kalman Filter (SEKF) over 3.5 years. The benefit of the assimilation is tested by comparison to a delayed cut-off version of SIM, in which the land surface is forced with more accurate atmospheric analyses, due to the availability of additional atmospheric observations after the near-real time data cut-off. However, comparing the near-real time and delayed cut-off SIM models revealed that the main difference between them is a dry bias in the near-real time precipitation forcing, which resulted in a dry bias in the root-zone soil moisture and associated surface moisture flux forecasts. While assimilating the ASCAT data did reduce the root-zone soil moisture dry bias (by nearly 50%), this was more likely due to a bias within the SEKF, than due to the assimilation having accurately responded to the precipitation errors. Several improvements to the assimilation are identified to address this, and a bias-aware strategy is suggested for explicitly correcting the model bias. However, in this experiment the moisture added by the SEKF was quickly lost from the model surface due to the enhanced surface fluxes (particularly drainage) induced by the wetter soil moisture states. Consequently, by the end of each winter, during which frozen conditions prevent the ASCAT data from being assimilated, the model land surface had returned to its original (dry-biased) climate. This highlights that it would be more effective to address the precipitation bias directly, than to correct it by constraining the model soil moisture through data assimilation.

Journal ArticleDOI
TL;DR: A time-efficient solution to estimate the error of satellite surface soil moisture from the land parameter retrieval model is presented and could substitute computationally intensive methods for near-real-time data assimilation studies where both the soil moisture product and error estimate are needed.
Abstract: A time-efficient solution to estimate the error of satellite surface soil moisture from the land parameter retrieval model is presented. The errors are estimated using an analytical solution for soil moisture retrievals from this radiative-transfer-based model that derives soil moisture from low-frequency passive microwave observations. The error estimate is based on a basic error propagation equation which uses the partial derivatives of the radiative transfer equation and estimated errors for each individual input parameter. Results similar to those of the Monte Carlo approach show that the developed time-efficient methodology could substitute computationally intensive methods. This procedure is therefore a welcome solution for near-real-time data assimilation studies where both the soil moisture product and error estimate are needed. The developed method is applied to the C-, X-, and Ku-bands of the Aqua/Advanced Microwave Scanning Radiometer for Earth Observing System sensor to study differences in errors between frequencies.

Journal ArticleDOI
TL;DR: HPL is a suitable serum supplement for isolation of MSC from adipose tissue and facilitates more population doublings than FCS, and predicts that low plating densities result in more heterogeneity with regard to cell division history, and favor subpopulations of higher migratory activity.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, J. Abdallah3, A. A. Abdelalim4  +3015 moreInstitutions (181)
TL;DR: A measurement of the differential cross-section for the inclusive production of isolated prompt photons in pp collisions at a center-of-mass energy root s = 7 TeV is presented in this article.

Journal ArticleDOI
TL;DR: MiR‐369‐5p and miR‐371 are identified as antagonistic up‐stream regulators of adipogenic differentiation and this might be indirectly mediated by epigenetic modifications.
Abstract: Long-term culture of human mesenchymal stromal cells (MSC) has implications on their proliferation and differentiation potential and we have demonstrated that this is associated with up-regulation of the five microRNAs miR-29c, miR-369-5p, miR-371, miR-499, and let-7f. In this study, we examined the role of these senescence-associated microRNAs for cellular aging and differentiation of MSC. Proliferation was reduced upon transfection with miR-369-5p, miR-371, and miR-499. Adipogenic differentiation was impaired by miR-369-5p whereas it was highly increased by miR-371. This was accompanied by respective gene expression changes of some adipogenic key molecules (adiponectin and fatty acid-binding protein 4 [FABP4]). Furthermore luciferase reporter assay indicated that FABP4 is a direct target of miR-369-5p. Microarray analysis upon adipogenic or osteogenic differentiation revealed down-regulation of several microRNAs albeit miR-369-5p and miR-371 were not affected. Expression of the de novo DNA methyltransferases DNMT3A and DNMT3B was up-regulated by transfection of miR-371 whereas expression of DNMT3A was down-regulated by miR-369-5p. In summary, we identified miR-369-5p and miR-371 as antagonistic up-stream regulators of adipogenic differentiation and this might be indirectly mediated by epigenetic modifications.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah3, A. A. Abdelalim4  +3002 moreInstitutions (188)
TL;DR: In this paper, the jet fragmentation function and transverse profile for jets with 25 GeV < p(Tjet) < 500 GeV and |eta(jet)| < 1.2 produced in proton-proton collisions with a center-of-mass energy of 7 TeV are presented.
Abstract: The jet fragmentation function and transverse profile for jets with 25 GeV < p(Tjet) < 500 GeV and |eta(jet)| < 1.2 produced in proton-proton collisions with a center-of-mass energy of 7 TeV are presented. The measurement is performed using data with an integrated luminosity of 36 pb(-1). Jets are reconstructed and their momentum measured using calorimetric information. The momenta of the charged particle constituents are measured using the tracking system. The distributions corrected for detector effects are compared with various Monte Carlo event generators and generator tunes. Several of these choices show good agreement with the measured fragmentation function. None of these choices reproduce both the transverse profile and fragmentation function over the full kinematic range of the measurement.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, J. Abdallah3, A. A. Abdelalim4  +3019 moreInstitutions (178)
TL;DR: In this article, a measurement of the Z/gamma* transverse momentum distribution in proton-proton collisions at root s = 7 TeV is presented using Z/Gamma* -> e(+)e(-) and Z/amma*-> mu(+)mu(-) decay.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, J. Abdallah3, A. A. Abdelalim4  +3114 moreInstitutions (193)
TL;DR: In this paper, the authors measured the jet shapes in the ATLAS experiment at the LHC and compared the results with several leading-order QCD matrix elements plus parton shower Monte Carlo predictions, including different sets of parameters tuned to model fragmentation processes and underlying event contributions in the final state.
Abstract: Jet shapes have been measured in inclusive jet production in proton-proton collisions at root s = 7 TeV using 3 pb(-1) of data recorded by the ATLAS experiment at the LHC. Jets are reconstructed using the anti-k(t) algorithm with transverse momentum 30 GeV < p(T) < 600 GeV and rapidity in the region vertical bar y vertical bar < 2.8. The data are corrected for detector effects and compared to several leading-order QCD matrix elements plus parton shower Monte Carlo predictions, including different sets of parameters tuned to model fragmentation processes and underlying event contributions in the final state. The measured jets become narrower with increasing jet transverse momentum and the jet shapes present a moderate jet rapidity dependence. Within QCD, the data test a variety of perturbative and nonperturbative effects. In particular, the data show sensitivity to the details of the parton shower, fragmentation, and underlying event models in the Monte Carlo generators. For an appropriate choice of the parameters used in these models, the data are well described.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, J. Abdallah, A. A. Abdelalim3  +3023 moreInstitutions (181)
TL;DR: In this article, a search for neutral Higgs bosons decaying to pairs of tau leptons with the ATLAS detector at the LHC is presented, based on proton-proton collisions at a center-of-mass energy of 7 TeV, recorded in 2010 and corresponding to an integrated luminosity of 36 pb^-1.

Journal ArticleDOI
TL;DR: The supportive effect of MSCs on hematopoiesis can be significantly increased by addition of specific recombinant growth factors; especially in combination with SCF, TPO, and FGF-1.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah, A. A. Abdelalim3  +3013 moreInstitutions (177)
TL;DR: In this paper, a search for new phenomena in events featuring a high energy jet and large missing transverse momentum in proton-proton collisions at root s = 7 TeV is presented using a dataset corresponding to an integrated luminosity of 33 pb(-1) recorded with the ATLAS detector at the Large Hadron Collider.

Journal ArticleDOI
TL;DR: In this article, an efficient particle simulation method for the Boltzmann transport equation based on the low-variance deviational simulation Monte Carlo approach to the variable-hard-sphere gas was proposed.
Abstract: We present an efficient particle simulation method for the Boltzmann transport equation based on the low-variance deviational simulation Monte Carlo approach to the variable-hard-sphere gas. The proposed method exhibits drastically reduced statistical uncertainty for low-signal problems compared to standard particle methods such as the direct simulation Monte Carlo method. We show that by enforcing mass conservation, accurate simulations can be performed in the transition regime requiring as few as ten particles per cell, enabling efficient simulation of multidimensional problems at arbitrarily small deviation from equilibrium.

Journal ArticleDOI
TL;DR: The authors surveys the deployment provisions of 49 contemporary democracies to establish whether and how parliaments are actually involved in deployment decisions, and demonstrates that the rules for parliamentary participation mark a continuum that ranges from complete exclusion to a comprehensive veto position of parliament over all potential deployments.
Abstract: Parliamentary approval can be of crucial importance to ensure the democratic legitimacy of military operations as it can establish public consent to the executives use of force. But involving parliament in decisions to deploy military forces may have negative repercussions on the efficiency of operations, e.g. by slowing down decision-making. As the military activity of democracies has been on the rise since the end of the Cold War, democracies around the world have been increasingly pressed to deal with this trade-off between legitimacy and efficiency in sending troops abroad. This paper surveys the deployment provisions of 49 contemporary democracies to establish whether and how parliaments are actually involved in deployment decisions. It demonstrates that the rules for parliamentary participation mark a continuum that ranges from complete exclusion to a comprehensive veto position of parliament over all potential deployments. In between these two extremes, democracies have found a wide variety of solutions to cope with the legitimacy-efficiency problem. Despite the growing prevalence of military deployments, there is no discernible trend towards parliamentarisation, however. Rather the trend towards internationalisation of security policies contributed to a weakening of parliamentary powers in some countries.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, J. Abdallah3, A. A. Abdelalim4  +3035 moreInstitutions (179)
TL;DR: In this article, the first measurement of the W + jets cross section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC with the ATLAS detector was reported.

Journal ArticleDOI
Georges Aad, Brad Abbott1, Jalal Abdallah2, A. A. Abdelalim3  +2998 moreInstitutions (176)
TL;DR: In this paper, the authors measured the inclusive and dijet production cross-sections for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of root s = 7 TeV, using the ATLAS detector at the LHC.
Abstract: The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of root s = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb(-1). The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b-hadrons in jets are reconstructed using information from the tracking detectors, or a muon-based method where the presence of a muon is used to identify semileptonic decays of b-hadrons inside jets. The inclusive b-jet cross-section is measured as a function of transverse momentum in the range 20 -dijet cross-section is measured as a function of the dijet invariant mass in the range 110 < m(jj) < 760 GeV, the azimuthal angle difference between the two jets and the angular variable chi in two dijet mass regions. The results are compared with next-to-leading-order QCD predictions. Good agreement is observed between the measured cross-sections and the predictions obtained using POWHEG + Pythia. MC@NLO + Herwig shows good agreement with the measured b (b) over bar -dijet cross-section. However, it does not reproduce the measured inclusive cross-section well, particularly for central b-jets with large transverse momenta.